MX2021007446A - Epítopos artificiales promiscuos de linfocitos t colaboradores como estimuladores inmunes para inmunógenos peptídicos sintéticos. - Google Patents

Epítopos artificiales promiscuos de linfocitos t colaboradores como estimuladores inmunes para inmunógenos peptídicos sintéticos.

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Publication number
MX2021007446A
MX2021007446A MX2021007446A MX2021007446A MX2021007446A MX 2021007446 A MX2021007446 A MX 2021007446A MX 2021007446 A MX2021007446 A MX 2021007446A MX 2021007446 A MX2021007446 A MX 2021007446A MX 2021007446 A MX2021007446 A MX 2021007446A
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Mexico
Prior art keywords
epitopes
antigenic site
cell
peptide
artificial
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MX2021007446A
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English (en)
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Chang Yi Wang
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United Biomedical Inc
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Publication date
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Publication of MX2021007446A publication Critical patent/MX2021007446A/es

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Abstract

La presente invención está dirigida a nuevos epítopos de linfocitos T colaboradores promiscuos y artificiales (epítopos Th) diseñados para proporcionar una inmunogenicidad óptima de un sitio antigénico diana. El sitio antigénico diana puede incluir un epítopo de linfocitos B, un epítopo CTL, un hapteno peptídico, un hapteno no peptídico o cualquier análogo inmunológicamente reactivo de estos. Los epítopos Th descritos, cuando se unen covalentemente a un sitio antigénico diana en una construcción inmunogénica peptídica, provocan una fuerte respuesta de anticuerpos de linfocitos B o una respuesta de linfocitos T efectores al sitio antigénico diana. Los epítopos Th se encuentran inactivados por sí mismos, es decir, pocos o ninguno de los anticuerpos generados por las construcciones inmunogénicas peptídicas se dirigirán hacia el epítopo Th, lo que permite, de esta manera, una respuesta inmune muy focalizada dirigida al sitio antigénico diana. Los epítopos Th artificiales promiscuos proporcionan inmunógenos peptídicos eficaces y seguros que no generan respuestas inmunitarias inflamatorias, contrarias a sí mismas, mediadas por células luego de la administración.
MX2021007446A 2018-12-19 2019-12-19 Epítopos artificiales promiscuos de linfocitos t colaboradores como estimuladores inmunes para inmunógenos peptídicos sintéticos. MX2021007446A (es)

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Application Number Priority Date Filing Date Title
US201862782253P 2018-12-19 2018-12-19
PCT/US2019/067532 WO2020132275A1 (en) 2018-12-19 2019-12-19 Artificial promiscuous t helper cell epitopes as immune stimulators for synthetic peptide immunogens

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MX2021007446A true MX2021007446A (es) 2021-09-08

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WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
MA52011A (fr) 2018-03-16 2021-01-20 Zoetis Services Llc Vaccins peptidiques contre l'interleukine-31
CA3125286A1 (en) * 2018-12-28 2020-07-02 United Biomedical, Inc. Peptide immunogens targeting interleukin 6 (il-6) and formulations thereof for immunotherapy of diseases impacted by il-6 dysregulation
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
CN113956330B (zh) * 2020-08-26 2023-08-18 中国农业科学院兰州兽医研究所 一类促进猪机体产生广谱性免疫应答的多肽及其应用
WO2022049280A1 (en) * 2020-09-04 2022-03-10 Dompe' Farmaceutici Spa Peptides endowed with angiogenic activity
CN114989269B (zh) * 2022-06-30 2023-09-19 天康制药股份有限公司 一种牛赤羽免疫原性抗原及疫苗
WO2024015611A2 (en) * 2022-07-14 2024-01-18 Vaxxinity, Inc. Tau peptide immunogen constructs
WO2024173143A2 (en) * 2023-02-13 2024-08-22 Cyw Investment Co., Ltd Vaccines incorporating hiv th/ctl epitope peptides to prevent and treat patients with hiv infection and aids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229679B (en) 1998-06-20 2005-03-21 United Biomedical Inc Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
US6107021A (en) 1998-06-20 2000-08-22 United Biomedical, Inc. Synthetic peptide vaccines for foot-and-mouth disease
CN101721698B (zh) * 2008-10-24 2014-04-02 法罗斯疫苗公司 抗口蹄疫疫苗组合物及其制备和应用
US9102752B2 (en) * 2013-03-15 2015-08-11 United Biomedical, Inc. Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type

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