MX2021005363A - Proteinas inhibidoras de insectos novedosas. - Google Patents
Proteinas inhibidoras de insectos novedosas.Info
- Publication number
- MX2021005363A MX2021005363A MX2021005363A MX2021005363A MX2021005363A MX 2021005363 A MX2021005363 A MX 2021005363A MX 2021005363 A MX2021005363 A MX 2021005363A MX 2021005363 A MX2021005363 A MX 2021005363A MX 2021005363 A MX2021005363 A MX 2021005363A
- Authority
- MX
- Mexico
- Prior art keywords
- tic7941pl
- disclosed
- pesticidal
- proteins
- nucleic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/25—Paenibacillus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A01H1/12—Processes for modifying agronomic input traits, e.g. crop yield
- A01H1/122—Processes for modifying agronomic input traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- A01H1/1245—Processes for modifying agronomic input traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, e.g. pathogen, pest or disease resistance
- A01H1/127—Processes for modifying agronomic input traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, e.g. pathogen, pest or disease resistance for insect resistance
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/10—Seeds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Botany (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Dentistry (AREA)
- Insects & Arthropods (AREA)
- Agronomy & Crop Science (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Abstract
Se revelan proteínas pesticidas que presentan actividad de toxina contra especies de plaga Lepidopteran, e incluyen, aunque sin limitación a, TIC7941, TIC7941PL_1, TIC7941PL_2, y TIC7941PL_3. Se proporcionan constructos de ADN que contienen una secuencia de ácido nucleico recombinante que codifica una o más de las proteínas pesticidas reveladas. Se proporcionan plantas transgénicas, células vegetales, semilla, y partes de plantas resistentes a infestaciones Lepidopteran que contienen secuencias de ácido nucleico recombinantes que codifican las proteínas pesticidas de la presente invención. También se proporcionan métodos para detectar la presencia de las secuencias de ácido nucleico recombinante o las proteínas de la presente invención en una muestra biológica, y métodos para controlar plagas de especie Lepidopteran usando cualquiera de las proteínas pesticidas TIC7941, TIC7941PL_1, TIC7941PL_2, y TIC7941PL_3. Métodos y composición para mejorar la actividad insecticida de una proteína pesticida contra una especie de plaga de insectos también son revelados. También se revela el método y la composición para reducir la expresión de una proteína pesticida en los tejidos reproductivos de una planta transgénica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962795066P | 2019-01-22 | 2019-01-22 | |
PCT/US2020/014437 WO2020154301A1 (en) | 2019-01-22 | 2020-01-21 | Novel insect inhibitory proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021005363A true MX2021005363A (es) | 2021-06-30 |
Family
ID=71608677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021005363A MX2021005363A (es) | 2019-01-22 | 2020-01-21 | Proteinas inhibidoras de insectos novedosas. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11266151B2 (es) |
EP (1) | EP3914608A4 (es) |
KR (1) | KR20210118055A (es) |
CN (1) | CN112955555B (es) |
AR (1) | AR117865A1 (es) |
AU (1) | AU2020212955A1 (es) |
BR (1) | BR112021006574A2 (es) |
CA (1) | CA3115551A1 (es) |
CL (2) | CL2021001055A1 (es) |
CO (1) | CO2021006033A2 (es) |
CR (1) | CR20210231A (es) |
EA (1) | EA202190969A1 (es) |
MX (1) | MX2021005363A (es) |
UY (1) | UY38551A (es) |
WO (1) | WO2020154301A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11965169B2 (en) | 2020-08-20 | 2024-04-23 | AG Biomolecules LLC | Transgenic safflower event stack IND-1ØØØ3-4 x IND-1ØØ15-7 and methods to use it |
CA3206159A1 (en) | 2020-12-21 | 2022-06-30 | Monsanto Technology Llc | Novel insect inhibitory proteins |
UY39585A (es) | 2020-12-23 | 2022-07-29 | Monsanto Technology Llc | Proteínas que exhiben actividad inhibidora de insectos frente a plagas con importancia agrícola de plantas de cultivo y semillas |
US11673922B2 (en) | 2020-12-31 | 2023-06-13 | Monsanto Technology Llc | Insect inhibitory proteins |
EP4271189A2 (en) | 2021-01-03 | 2023-11-08 | Impetus Agriculture, Inc. | Novel affinity constructs and methods for their use |
WO2023010013A1 (en) * | 2021-07-27 | 2023-02-02 | BASF Agricultural Solutions Seed US LLC | Viral coat delivery of insect resistance genes in plants |
CN116064644B (zh) * | 2022-10-10 | 2023-10-10 | 中国农业科学院生物技术研究所 | SbAGO1b蛋白及其编码基因在调控植物抗虫性中的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2562022C (en) | 2004-04-09 | 2016-01-26 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
US7521235B2 (en) | 2006-07-21 | 2009-04-21 | Pioneer Hi-Bred International, Inc. | Unique novel Bacillus thuringiensis gene with Lepidopteran activity |
US8148077B2 (en) | 2006-07-21 | 2012-04-03 | Pioneer Hi-Bred International, Inc. | Method for identifying novel genes |
US20080300210A1 (en) | 2007-05-16 | 2008-12-04 | Wisconsin Alumni Research Foundation | Method of Controlling Insects and Virus Transmission |
US7772465B2 (en) | 2007-06-26 | 2010-08-10 | Pioneer Hi-Bred International, Inc. | Bacillus thuringiensis gene with lepidopteran activity |
US8283524B2 (en) | 2008-05-15 | 2012-10-09 | Pioneer Hi-Bred International, Inc | Bacillus thuringiensis gene with lepidopteran activity |
CN102076858B (zh) | 2008-06-11 | 2013-10-30 | 先锋国际良种公司 | 具有鳞翅目活性的新的苏云金芽孢杆菌基因 |
US8445749B2 (en) | 2008-09-19 | 2013-05-21 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
US20100077507A1 (en) | 2008-09-22 | 2010-03-25 | Pioneer Hi-Bred International, Inc. | Novel Bacillus Thuringiensis Gene with Lepidopteran Activity |
US8692065B2 (en) | 2009-01-23 | 2014-04-08 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
US8772577B2 (en) | 2009-11-12 | 2014-07-08 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
WO2011084324A2 (en) | 2009-12-21 | 2011-07-14 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
WO2012024200A2 (en) | 2010-08-19 | 2012-02-23 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
BR112013015515A2 (pt) | 2010-12-28 | 2018-04-24 | Pioneer Hi Bred Int | molécula de ácido nucleico isolada, construto de dna, célula hospedeira, planta transgênica, semente transformada da planta, polipeptídeo isolado com atividade pesticida, composição, método para controlar uma população de praga de lepidóptero, método para matar uma praga de lepidóptero, método para produzir um polipeptídeo com atividade pesticida, planta que tem incorporado de maneira estável em seu genoma um construto de dna, método para proteger uma planta contra uma praga |
EA202091496A1 (ru) * | 2011-04-05 | 2020-09-30 | Басф Агрикалчерал Солюшнс Сид Юс Ллк | Вариант инсектицидного гена axmi115 и способы его применения |
MX346662B (es) | 2011-04-07 | 2017-03-27 | Monsanto Technology Llc | Familia de toxinas inhibidoras de insectos activas contra insectos hemipteros y lepidopteros. |
US9567381B2 (en) * | 2012-03-09 | 2017-02-14 | Vestaron Corporation | Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides |
MY189005A (en) * | 2015-08-27 | 2022-01-18 | Monsanto Technology Llc | Novel insect inhibitory proteins |
US10612037B2 (en) * | 2016-06-20 | 2020-04-07 | Monsanto Technology Llc | Insecticidal proteins toxic or inhibitory to hemipteran pests |
-
2020
- 2020-01-21 EP EP20745577.5A patent/EP3914608A4/en active Pending
- 2020-01-21 AU AU2020212955A patent/AU2020212955A1/en active Pending
- 2020-01-21 US US16/748,392 patent/US11266151B2/en active Active
- 2020-01-21 BR BR112021006574-1A patent/BR112021006574A2/pt unknown
- 2020-01-21 CR CR20210231A patent/CR20210231A/es unknown
- 2020-01-21 CN CN202080005803.XA patent/CN112955555B/zh active Active
- 2020-01-21 CA CA3115551A patent/CA3115551A1/en active Pending
- 2020-01-21 EA EA202190969A patent/EA202190969A1/ru unknown
- 2020-01-21 WO PCT/US2020/014437 patent/WO2020154301A1/en unknown
- 2020-01-21 KR KR1020217011813A patent/KR20210118055A/ko unknown
- 2020-01-21 MX MX2021005363A patent/MX2021005363A/es unknown
- 2020-01-22 AR ARP200100160A patent/AR117865A1/es unknown
- 2020-01-22 UY UY0001038551A patent/UY38551A/es unknown
-
2021
- 2021-04-23 CL CL2021001055A patent/CL2021001055A1/es unknown
- 2021-05-10 CO CONC2021/0006033A patent/CO2021006033A2/es unknown
-
2022
- 2022-01-26 US US17/584,677 patent/US20220248686A1/en active Pending
- 2022-11-17 CL CL2022003221A patent/CL2022003221A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20200229445A1 (en) | 2020-07-23 |
CN112955555A (zh) | 2021-06-11 |
AR117865A1 (es) | 2021-09-01 |
EA202190969A1 (ru) | 2021-10-18 |
US20220248686A1 (en) | 2022-08-11 |
KR20210118055A (ko) | 2021-09-29 |
EP3914608A1 (en) | 2021-12-01 |
CA3115551A1 (en) | 2020-07-30 |
CN112955555B (zh) | 2024-09-03 |
US11266151B2 (en) | 2022-03-08 |
WO2020154301A1 (en) | 2020-07-30 |
CL2021001055A1 (es) | 2021-10-01 |
EP3914608A4 (en) | 2023-05-17 |
CR20210231A (es) | 2021-08-26 |
AU2020212955A1 (en) | 2021-05-06 |
CL2022003221A1 (es) | 2023-04-21 |
CO2021006033A2 (es) | 2021-05-20 |
UY38551A (es) | 2020-08-31 |
BR112021006574A2 (pt) | 2021-08-10 |
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