MX2021004864A - Formulacion basada en ciclodextrina de un inhibidor de bcl-2. - Google Patents
Formulacion basada en ciclodextrina de un inhibidor de bcl-2.Info
- Publication number
- MX2021004864A MX2021004864A MX2021004864A MX2021004864A MX2021004864A MX 2021004864 A MX2021004864 A MX 2021004864A MX 2021004864 A MX2021004864 A MX 2021004864A MX 2021004864 A MX2021004864 A MX 2021004864A MX 2021004864 A MX2021004864 A MX 2021004864A
- Authority
- MX
- Mexico
- Prior art keywords
- cyclodextrin
- pharmaceutical composition
- relates
- bcl
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a una composición farmacéutica que comprende 5-(5-cloro-2-{[(3S)-3-(morfolin-4-ilmetil)-3,4-dihidrois oquinolin-2(1H)-il]carbonil}fenil)-N-(5-ciano-1,2-dimetil-1H-pirr ol-3-il)-N-(4-hidroxifenil)-1,2-dimetil-1H-pirrol-3-carboxamida, referida en la presente memoria como "Compuesto A", o una sal farmacéuticamente aceptable de la misma, y una ciclodextrina. Más específicamente, la invención se refiere a una composición farmacéutica sólida que comprende el Compuesto A y una ciclodextrina, y una composición farmacéutica para administración parenteral preparada disolviendo esta composición farmacéutica sólida. Además, la invención se refiere al uso de dichas composiciones para el tratamiento del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862753164P | 2018-10-31 | 2018-10-31 | |
PCT/EP2019/079644 WO2020089286A1 (en) | 2018-10-31 | 2019-10-30 | Cyclodextrin-based formulation of a bcl-2 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021004864A true MX2021004864A (es) | 2021-08-11 |
Family
ID=68536777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021004864A MX2021004864A (es) | 2018-10-31 | 2019-10-30 | Formulacion basada en ciclodextrina de un inhibidor de bcl-2. |
Country Status (25)
Country | Link |
---|---|
US (1) | US20210353633A1 (es) |
EP (1) | EP3873529A1 (es) |
JP (1) | JP2022506069A (es) |
KR (1) | KR20210102886A (es) |
CN (1) | CN112912108A (es) |
AR (1) | AR116922A1 (es) |
AU (1) | AU2019373373B2 (es) |
BR (1) | BR112021007987A2 (es) |
CA (1) | CA3117511A1 (es) |
CL (1) | CL2021001018A1 (es) |
CO (1) | CO2021005221A2 (es) |
CR (1) | CR20210210A (es) |
DO (1) | DOP2021000073A (es) |
EA (1) | EA202191144A1 (es) |
GE (1) | GEP20237580B (es) |
IL (1) | IL282688A (es) |
JO (1) | JOP20210079A1 (es) |
MX (1) | MX2021004864A (es) |
NI (1) | NI202100031A (es) |
PE (1) | PE20211738A1 (es) |
PH (1) | PH12021550878A1 (es) |
SG (1) | SG11202103965TA (es) |
TW (1) | TWI738100B (es) |
UY (1) | UY38431A (es) |
WO (1) | WO2020089286A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116390735A (zh) | 2020-07-31 | 2023-07-04 | 法国施维雅药厂 | 治疗癌症的Bcl-2抑制剂和低甲基化剂的组合、其用途和药物组合物 |
WO2022090443A1 (en) | 2020-10-30 | 2022-05-05 | Les Laboratoires Servier | Administration and dose regimen for a combination of a bcl-2 inhibitor and a mcl1 inhibitor |
CA3214107A1 (en) | 2021-03-24 | 2022-09-29 | Les Laboratoires Servier | New process for the synthesis of 5-{5-chloro-2-[(3s)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996041646A2 (en) * | 1995-06-13 | 1996-12-27 | Dyer, Alison, Margaret | Pharmaceutical compositions containing lornoxicam and cyclodextrin |
JP2003321364A (ja) * | 2002-05-07 | 2003-11-11 | Eisai Co Ltd | シクロデキストリンにより可溶化及び安定化された抗腫瘍剤含有組成物 |
WO2014108918A2 (en) * | 2013-01-08 | 2014-07-17 | Mylan Laboratories Limited | An injectable antifungal formulation |
FR3008975A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2018081830A1 (en) * | 2016-10-31 | 2018-05-03 | Oregon Health & Science University | Combinations of agents to treat hematological malignancies |
-
2019
- 2019-10-29 UY UY0001038431A patent/UY38431A/es unknown
- 2019-10-30 CN CN201980070474.4A patent/CN112912108A/zh active Pending
- 2019-10-30 AU AU2019373373A patent/AU2019373373B2/en active Active
- 2019-10-30 KR KR1020217016354A patent/KR20210102886A/ko active Search and Examination
- 2019-10-30 CA CA3117511A patent/CA3117511A1/en active Pending
- 2019-10-30 SG SG11202103965TA patent/SG11202103965TA/en unknown
- 2019-10-30 EP EP19801728.7A patent/EP3873529A1/en active Pending
- 2019-10-30 JO JOP/2021/0079A patent/JOP20210079A1/ar unknown
- 2019-10-30 JP JP2021523227A patent/JP2022506069A/ja active Pending
- 2019-10-30 GE GEAP201915618A patent/GEP20237580B/en unknown
- 2019-10-30 EA EA202191144A patent/EA202191144A1/ru unknown
- 2019-10-30 PE PE2021000642A patent/PE20211738A1/es unknown
- 2019-10-30 US US17/288,721 patent/US20210353633A1/en active Pending
- 2019-10-30 MX MX2021004864A patent/MX2021004864A/es unknown
- 2019-10-30 CR CR20210210A patent/CR20210210A/es unknown
- 2019-10-30 WO PCT/EP2019/079644 patent/WO2020089286A1/en active Application Filing
- 2019-10-30 BR BR112021007987-4A patent/BR112021007987A2/pt unknown
- 2019-10-30 AR ARP190103144A patent/AR116922A1/es unknown
- 2019-10-30 TW TW108139349A patent/TWI738100B/zh active
-
2021
- 2021-04-20 PH PH12021550878A patent/PH12021550878A1/en unknown
- 2021-04-21 DO DO2021000073A patent/DOP2021000073A/es unknown
- 2021-04-21 CL CL2021001018A patent/CL2021001018A1/es unknown
- 2021-04-23 CO CONC2021/0005221A patent/CO2021005221A2/es unknown
- 2021-04-27 IL IL282688A patent/IL282688A/en unknown
- 2021-04-29 NI NI202100031A patent/NI202100031A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20210353633A1 (en) | 2021-11-18 |
UY38431A (es) | 2020-05-29 |
PH12021550878A1 (en) | 2021-10-18 |
KR20210102886A (ko) | 2021-08-20 |
IL282688A (en) | 2021-06-30 |
DOP2021000073A (es) | 2021-11-15 |
AU2019373373B2 (en) | 2023-09-28 |
EA202191144A1 (ru) | 2021-09-27 |
CA3117511A1 (en) | 2020-05-07 |
CO2021005221A2 (es) | 2021-07-19 |
NI202100031A (es) | 2021-08-24 |
GEP20237580B (en) | 2023-12-25 |
CN112912108A (zh) | 2021-06-04 |
AR116922A1 (es) | 2021-06-30 |
JOP20210079A1 (ar) | 2023-01-30 |
WO2020089286A1 (en) | 2020-05-07 |
AU2019373373A1 (en) | 2021-05-20 |
JP2022506069A (ja) | 2022-01-17 |
EP3873529A1 (en) | 2021-09-08 |
TW202031295A (zh) | 2020-09-01 |
PE20211738A1 (es) | 2021-09-06 |
CR20210210A (es) | 2021-05-25 |
TWI738100B (zh) | 2021-09-01 |
SG11202103965TA (en) | 2021-05-28 |
CL2021001018A1 (es) | 2021-11-26 |
BR112021007987A2 (pt) | 2021-08-03 |
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