MX2021004069A - Enlazadores de conjugacion que contienen el grupo 2,3-diaminosuccinilo. - Google Patents

Enlazadores de conjugacion que contienen el grupo 2,3-diaminosuccinilo.

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Publication number
MX2021004069A
MX2021004069A MX2021004069A MX2021004069A MX2021004069A MX 2021004069 A MX2021004069 A MX 2021004069A MX 2021004069 A MX2021004069 A MX 2021004069A MX 2021004069 A MX2021004069 A MX 2021004069A MX 2021004069 A MX2021004069 A MX 2021004069A
Authority
MX
Mexico
Prior art keywords
linker
diaminosuccinyl
group
bis
molecule
Prior art date
Application number
MX2021004069A
Other languages
English (en)
Inventor
Yuanyuan Huang
Qingliang Yang
Shun Gai
Hangbo Ye
Chengyu Yang
Huihui Guo
Xiaomai Zhou
Hongsheng Xie
Qianqian Tong
Linyao Zhao
Junxiang Jia
Wenjun Li
Chen Lin
Yifang Xu
Zhixiang Guo
Lu Bai
Yanlei Yang
Robert Yongxin Zhao
Zhicang Ye
Jun Zheng
Jun Lei
Xiaotao Zhuo
Mingjun Chao
Yanhong Tong
Binbin Chen
Original Assignee
Hangzhou Dac Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Dac Biotech Co Ltd filed Critical Hangzhou Dac Biotech Co Ltd
Publication of MX2021004069A publication Critical patent/MX2021004069A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)

Abstract

Se provee un conjugado de una molécula o fármaco citotóxicos con una molécula de unión a células con un enlazador bis (enlazador dual) que contiene un grupo 2,3-diaminosuccinilo,. También se hace referencia a la preparación del conjugado de un fármaco o molécula citotóxicos con una molécula de unión a células con un enlazador bis, en particular cuando el fármaco tiene grupos de amino, hidroxilo, diamino, amino-hidroxilo, dihidroxilo, carboxilo, hidrazina, aldehído y tiol para su conjugación con el enlazador bis en una forma específica, así cómo también al uso terapéutico de los conjugados.
MX2021004069A 2018-10-12 2018-10-12 Enlazadores de conjugacion que contienen el grupo 2,3-diaminosuccinilo. MX2021004069A (es)

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CA3108168A1 (en) * 2020-02-05 2021-08-05 Yue Zhang Conjugates of cell-binding molecules with cytotoxic agents
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GB202105186D0 (en) * 2021-04-12 2021-05-26 Medimmune Ltd Pyrrolobenzodiazepine conjugates
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WO2023205669A2 (en) * 2022-04-19 2023-10-26 Purdue Research Foundation Dual and triple hapten conjugates, compositions, processes for making, and methods of treatment therewith
CN115007177B (zh) * 2022-06-17 2023-06-23 四川大学 一种CdSeS幻数纳米团簇及其作为光催化剂的用途
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AU2022215217A1 (en) 2022-09-01
JP2024062987A (ja) 2024-05-10
CN113195487A (zh) 2021-07-30
US20230010108A1 (en) 2023-01-12
KR20240008407A (ko) 2024-01-18

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