MX2020012214A - Composiciones que comprenden moléculas que se unen a la pcsk9 y métodos de uso. - Google Patents
Composiciones que comprenden moléculas que se unen a la pcsk9 y métodos de uso.Info
- Publication number
- MX2020012214A MX2020012214A MX2020012214A MX2020012214A MX2020012214A MX 2020012214 A MX2020012214 A MX 2020012214A MX 2020012214 A MX2020012214 A MX 2020012214A MX 2020012214 A MX2020012214 A MX 2020012214A MX 2020012214 A MX2020012214 A MX 2020012214A
- Authority
- MX
- Mexico
- Prior art keywords
- pcsk9
- compositions
- methods
- binding molecules
- bind
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 102000006437 Proprotein Convertases Human genes 0.000 abstract 1
- 108010044159 Proprotein Convertases Proteins 0.000 abstract 1
- 108090000787 Subtilisin Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción proporciona composiciones farmacéuticas que comprenden proteínas del dominio de andamiaje basado en fibronectina que se unen, por ejemplo, a la proproteína convertasa subtilisina kexina-9 (PCSK9).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862672187P | 2018-05-16 | 2018-05-16 | |
PCT/US2019/032710 WO2019222529A1 (en) | 2018-05-16 | 2019-05-16 | Compositions comprising pcsk9-binding molecules and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020012214A true MX2020012214A (es) | 2021-03-31 |
Family
ID=68540981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020012214A MX2020012214A (es) | 2018-05-16 | 2019-05-16 | Composiciones que comprenden moléculas que se unen a la pcsk9 y métodos de uso. |
Country Status (12)
Country | Link |
---|---|
US (3) | US10738102B2 (es) |
EP (1) | EP3793612A4 (es) |
KR (1) | KR20210010890A (es) |
CN (1) | CN112423790A (es) |
AU (1) | AU2019269617A1 (es) |
BR (1) | BR112020023344A2 (es) |
CA (1) | CA3115341A1 (es) |
EA (1) | EA202092778A1 (es) |
MX (1) | MX2020012214A (es) |
SG (1) | SG11202011304QA (es) |
WO (1) | WO2019222529A1 (es) |
ZA (1) | ZA202007107B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020023344A2 (pt) * | 2018-05-16 | 2021-02-09 | Lib Therapeutics, Llc | composições compreendendo moléculas de ligação a pcsk9 e métodos de uso |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009131740A2 (en) * | 2008-04-23 | 2009-10-29 | Amgen Inc. | Neutralizing proprotein convertase subtilisin kexin type 9 (pcsk9) variants and uses thereof |
KR20130056871A (ko) * | 2010-04-13 | 2013-05-30 | 브리스톨-마이어스 스큅 컴퍼니 | Pcsk9에 결합하는 피브로넥틴 기반 스캐폴드 도메인 단백질 |
US9255154B2 (en) * | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
WO2014165093A2 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
WO2014140210A1 (en) * | 2013-03-14 | 2014-09-18 | Pieris Ag | Novel binding proteins for pcsk9 |
IL275497B (en) * | 2014-03-20 | 2022-09-01 | Bristol Myers Squibb Co | Serum proteins with type iii fibronectin binding domains |
JP6644701B2 (ja) * | 2014-03-20 | 2020-02-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 安定化したフィブロネクチンベーススキャフォールド分子 |
JP6862348B2 (ja) | 2015-03-12 | 2021-04-21 | メディミューン,エルエルシー | アルブミン融合タンパク質を精製する方法 |
BR112020023344A2 (pt) * | 2018-05-16 | 2021-02-09 | Lib Therapeutics, Llc | composições compreendendo moléculas de ligação a pcsk9 e métodos de uso |
EP4360642A1 (en) * | 2021-06-25 | 2024-05-01 | Gan & Lee Pharmaceuticals Co., Ltd. | Pharmaceutical composition of pcsk9 inhibitor and glp-1 receptor agonist |
-
2019
- 2019-05-16 BR BR112020023344-7A patent/BR112020023344A2/pt unknown
- 2019-05-16 WO PCT/US2019/032710 patent/WO2019222529A1/en unknown
- 2019-05-16 EP EP19804334.1A patent/EP3793612A4/en active Pending
- 2019-05-16 AU AU2019269617A patent/AU2019269617A1/en active Pending
- 2019-05-16 EA EA202092778A patent/EA202092778A1/ru unknown
- 2019-05-16 MX MX2020012214A patent/MX2020012214A/es unknown
- 2019-05-16 CA CA3115341A patent/CA3115341A1/en active Pending
- 2019-05-16 SG SG11202011304QA patent/SG11202011304QA/en unknown
- 2019-05-16 KR KR1020207035740A patent/KR20210010890A/ko unknown
- 2019-05-16 CN CN201980047552.9A patent/CN112423790A/zh active Pending
- 2019-09-20 US US16/578,102 patent/US10738102B2/en active Active
-
2020
- 2020-07-21 US US16/934,816 patent/US11692021B2/en active Active
- 2020-11-13 ZA ZA2020/07107A patent/ZA202007107B/en unknown
-
2023
- 2023-05-16 US US18/318,343 patent/US20230295270A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200071386A1 (en) | 2020-03-05 |
EA202092778A1 (ru) | 2021-05-27 |
AU2019269617A8 (en) | 2020-12-17 |
EP3793612A4 (en) | 2022-03-02 |
KR20210010890A (ko) | 2021-01-28 |
CA3115341A1 (en) | 2019-11-21 |
AU2019269617A1 (en) | 2020-12-03 |
SG11202011304QA (en) | 2020-12-30 |
US20210002350A1 (en) | 2021-01-07 |
US11692021B2 (en) | 2023-07-04 |
ZA202007107B (en) | 2022-03-30 |
BR112020023344A2 (pt) | 2021-02-09 |
US10738102B2 (en) | 2020-08-11 |
EP3793612A1 (en) | 2021-03-24 |
US20230295270A1 (en) | 2023-09-21 |
JP2021523214A (ja) | 2021-09-02 |
WO2019222529A1 (en) | 2019-11-21 |
CN112423790A (zh) | 2021-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY168961A (en) | Antibodies to pcsk9 and uses thereof | |
ZA201906011B (en) | Apoptosis-inducing agents | |
EA201890949A1 (ru) | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ | |
MX2020002290A (es) | Composicion liquida que comprende entidades biologicas y usos de la misma. | |
EA201791775A1 (ru) | Цистеиновая протеаза | |
EA201890749A1 (ru) | ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ | |
MY195442A (en) | Anti-CD40 Antibodies and Their Uses | |
MX2018016057A (es) | Composiciones y metodos para tratar enfermedades cardiovasculares. | |
TN2009000410A1 (en) | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9) | |
EA201592304A1 (ru) | Способы лечения аутосомно-доминантой гиперхолестеринемии, ассоциированной с мутацией приобретения функции гена pcsk9 | |
BR112015032736A2 (pt) | inibidores de bromodomínio cristalino | |
EA201391329A1 (ru) | Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3) | |
EA201690889A1 (ru) | Режимы дозирования для применения ингибиторов pcsk9 | |
PH12018502137A1 (en) | Anti-complement factor bb antibodies and uses thereof | |
EP3182971A4 (en) | Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(pcsk9) protein activity | |
MY197534A (en) | Anti-tryptase antibodies, compositions thereof, and uses thereof | |
PH12020551716A1 (en) | Anti-ror antibody constructs | |
WO2016172551A8 (en) | METHODS OF IDENTIFYING BACTERIA COMPRISING BINDING POLYPEPTIDES | |
MX2017008908A (es) | Proceso para la hidrólisis de queratina empleando proteasas. | |
JOP20200343A1 (ar) | بروتين ربط مولد ضد مضاد لـ steap1 | |
MX2020012214A (es) | Composiciones que comprenden moléculas que se unen a la pcsk9 y métodos de uso. | |
AU2016334102A8 (en) | CRMP2 SUMOylation inhibitors and uses thereof | |
BR112022009587A2 (pt) | Anticorpo anti-pcsk9 e uso do mesmo | |
WO2020102243A3 (en) | In-flow photooxygenation of aminothienopyridinones generates novel ptp4a3 phosphatase inhibitors | |
MX2021002013A (es) | Metodos para determinar la concentracion de proteinas o peptidos y sus usos. |