MX2020011376A - Formas polimórficas y amorfas de isoquinolinona y métodos de uso de estas. - Google Patents

Formas polimórficas y amorfas de isoquinolinona y métodos de uso de estas.

Info

Publication number
MX2020011376A
MX2020011376A MX2020011376A MX2020011376A MX2020011376A MX 2020011376 A MX2020011376 A MX 2020011376A MX 2020011376 A MX2020011376 A MX 2020011376A MX 2020011376 A MX2020011376 A MX 2020011376A MX 2020011376 A MX2020011376 A MX 2020011376A
Authority
MX
Mexico
Prior art keywords
polymorphic
isoquinolinone
methods
amorphous forms
methyl
Prior art date
Application number
MX2020011376A
Other languages
English (en)
Inventor
Jayachandra P Reddy
Jette Bisgaard Boll
Original Assignee
Sojournix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sojournix Inc filed Critical Sojournix Inc
Publication of MX2020011376A publication Critical patent/MX2020011376A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Formas polimórficas y amorfas de ((S)-ciclopropilfenil- metil)-amida del ácido 2-etilamino-8-fluoro-3-metil-1- oxo-1.2-dihidro-isoquinolin-4-carboxílico (también denominado en la presente como SJB-01). Las formas polimórficas pueden ser una forma alfa, beta o gamma.
MX2020011376A 2018-04-27 2019-04-29 Formas polimórficas y amorfas de isoquinolinona y métodos de uso de estas. MX2020011376A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862664020P 2018-04-27 2018-04-27
PCT/US2019/029751 WO2019210327A1 (en) 2018-04-27 2019-04-29 Polymorphic and amorphous forms of isoquinolinone and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2020011376A true MX2020011376A (es) 2021-02-09

Family

ID=68295819

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011376A MX2020011376A (es) 2018-04-27 2019-04-29 Formas polimórficas y amorfas de isoquinolinona y métodos de uso de estas.

Country Status (11)

Country Link
US (1) US20210371385A1 (es)
EP (1) EP3784244A1 (es)
JP (1) JP2021522341A (es)
KR (1) KR20210015795A (es)
CN (1) CN112384221A (es)
AU (1) AU2019260835A1 (es)
BR (1) BR112020021977A2 (es)
CA (1) CA3098603A1 (es)
MX (1) MX2020011376A (es)
SG (1) SG11202010583VA (es)
WO (1) WO2019210327A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0917245B8 (pt) * 2008-09-15 2021-05-25 H Lundbeck As compostos derivados de isoquinolinona e sua composição farmacêutica
US8242134B2 (en) * 2008-09-15 2012-08-14 H. Lundbeck A/S Isoquinolinone derivatives as NK3 antagonists

Also Published As

Publication number Publication date
JP2021522341A (ja) 2021-08-30
KR20210015795A (ko) 2021-02-10
AU2019260835A1 (en) 2020-11-19
WO2019210327A1 (en) 2019-10-31
US20210371385A1 (en) 2021-12-02
CA3098603A1 (en) 2019-10-31
SG11202010583VA (en) 2020-11-27
BR112020021977A2 (pt) 2021-01-26
EP3784244A1 (en) 2021-03-03
CN112384221A (zh) 2021-02-19

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