MX2020010360A - Sistemas, metodos y composicion de uso de mutantes de rnasa iii para producir sarn para controlar infeccion por patogeno huesped. - Google Patents

Sistemas, metodos y composicion de uso de mutantes de rnasa iii para producir sarn para controlar infeccion por patogeno huesped.

Info

Publication number
MX2020010360A
MX2020010360A MX2020010360A MX2020010360A MX2020010360A MX 2020010360 A MX2020010360 A MX 2020010360A MX 2020010360 A MX2020010360 A MX 2020010360A MX 2020010360 A MX2020010360 A MX 2020010360A MX 2020010360 A MX2020010360 A MX 2020010360A
Authority
MX
Mexico
Prior art keywords
methods
rnase iii
systems
iii mutants
composition
Prior art date
Application number
MX2020010360A
Other languages
English (en)
Inventor
Guohua Yin
Erick Scott Lebrun
Timothy S Travers
Original Assignee
Pebble Labs Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pebble Labs Usa Inc filed Critical Pebble Labs Usa Inc
Publication of MX2020010360A publication Critical patent/MX2020010360A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60—Isolated nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26003—Ribonuclease III (3.1.26.3)

Abstract

La presente invención incluye sistemas, métodos y composiciones para la generación de moléculas de sARN mediante el uso de mutantes de RNasa III seleccionados; en una forma de realización preferida, la invención incluye sistemas, métodos y composiciones para la generación de moléculas de sARN mediante el uso de mutantes de RNasa III para controlar un patógeno huésped a través de la producción y la difusión de moléculas de sARN que pueden iniciar una respuesta de la vía de ARNi dirigida a un patógeno huésped; las formas de realización adicionales de la presente invención incluyen sistemas, métodos y composiciones para la generación independiente de DICER de moléculas de sARN mediante el uso de mutantes de RNasa III seleccionados.
MX2020010360A 2018-03-31 2019-04-01 Sistemas, metodos y composicion de uso de mutantes de rnasa iii para producir sarn para controlar infeccion por patogeno huesped. MX2020010360A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862651143P 2018-03-31 2018-03-31
PCT/US2019/025261 WO2019191785A1 (en) 2018-03-31 2019-04-01 Systems, methods and composition of using rnase iii mutants to produce srna to control host pathogen infection

Publications (1)

Publication Number Publication Date
MX2020010360A true MX2020010360A (es) 2020-10-19

Family

ID=68060479

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010360A MX2020010360A (es) 2018-03-31 2019-04-01 Sistemas, metodos y composicion de uso de mutantes de rnasa iii para producir sarn para controlar infeccion por patogeno huesped.

Country Status (12)

Country Link
US (2) US11800872B2 (es)
EP (1) EP3775188A4 (es)
CN (1) CN112585260A (es)
AU (1) AU2019245479A1 (es)
CA (1) CA3095489A1 (es)
CO (1) CO2020013533A2 (es)
EC (1) ECSP20069005A (es)
MX (1) MX2020010360A (es)
PE (1) PE20211654A1 (es)
PH (1) PH12020551599A1 (es)
SG (1) SG11202009631WA (es)
WO (1) WO2019191785A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110857438B (zh) * 2018-08-20 2022-05-17 中国烟草总公司黑龙江省公司牡丹江烟草科学研究所 一种高效产生siRNA的烟草花叶病毒基因片段、弱毒疫苗、制备方法及其应用
WO2021173953A1 (en) * 2020-02-26 2021-09-02 Pebble Labs, Inc. Novel plant endophytic bacteria and methods to control plant pathogens and pests

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1256712A (zh) * 1997-04-03 2000-06-14 诺瓦提斯公司 植物病害控制
EP1084709A1 (en) 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oral recombinant lactobacilli vaccines
US20040029275A1 (en) 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
EP1706511A4 (en) * 2004-01-23 2010-04-07 New England Biolabs Inc COMPOSITIONS AND METHOD FOR GENERATING SHORT DOUBLE-STRENGTH RNA USING MUTED RNASE III
US9840703B2 (en) 2013-01-11 2017-12-12 Children's Medical Center Corporation Methods and compositions for the production of siRNAs
WO2015050184A1 (ja) * 2013-10-02 2015-04-09 味の素株式会社 ヘパロサン生産細菌及びヘパロサンの製造法

Also Published As

Publication number Publication date
US11800872B2 (en) 2023-10-31
WO2019191785A1 (en) 2019-10-03
SG11202009631WA (en) 2020-10-29
EP3775188A4 (en) 2022-02-09
CA3095489A1 (en) 2019-10-03
PH12020551599A1 (en) 2021-08-16
EP3775188A1 (en) 2021-02-17
ECSP20069005A (es) 2020-11-30
AU2019245479A1 (en) 2020-10-29
US20230354822A1 (en) 2023-11-09
US20210017523A1 (en) 2021-01-21
PE20211654A1 (es) 2021-08-24
CN112585260A (zh) 2021-03-30
CO2020013533A2 (es) 2020-11-10

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