MX2020004536A - Derivados de pirimidina como inhibidores del receptor de tropomiosina quinasa (trka). - Google Patents
Derivados de pirimidina como inhibidores del receptor de tropomiosina quinasa (trka).Info
- Publication number
- MX2020004536A MX2020004536A MX2020004536A MX2020004536A MX2020004536A MX 2020004536 A MX2020004536 A MX 2020004536A MX 2020004536 A MX2020004536 A MX 2020004536A MX 2020004536 A MX2020004536 A MX 2020004536A MX 2020004536 A MX2020004536 A MX 2020004536A
- Authority
- MX
- Mexico
- Prior art keywords
- trka
- inhibitors
- pyrimidine derivatives
- receptor kinase
- tropomyosin receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a nuevos inhibidores de TrkA de la formula (1) que son utiles en el tratamiento o prevencion del dolor agudo y cronico, pero tambien para otras actividades anormales de TrkA, mas alla de la terapia del dolor, tales como inflamacion y cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17203290 | 2017-11-23 | ||
PCT/EP2018/082183 WO2019101843A1 (en) | 2017-11-23 | 2018-11-22 | Pyrimidine derivatives as tropomyosin receptor kinase a (trka) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020004536A true MX2020004536A (es) | 2020-08-03 |
Family
ID=60484137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020004536A MX2020004536A (es) | 2017-11-23 | 2018-11-22 | Derivados de pirimidina como inhibidores del receptor de tropomiosina quinasa (trka). |
Country Status (10)
Country | Link |
---|---|
US (1) | US20200399250A1 (es) |
EP (1) | EP3672957A1 (es) |
JP (1) | JP2021504462A (es) |
KR (1) | KR20200090198A (es) |
CN (1) | CN111247139A (es) |
BR (1) | BR112020010120A2 (es) |
CA (1) | CA3076444A1 (es) |
MX (1) | MX2020004536A (es) |
RU (1) | RU2020115534A (es) |
WO (1) | WO2019101843A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210016397A (ko) | 2018-05-25 | 2021-02-15 | 에르덴 바놀루 | 신종 항암제 후보로서, 매우 강력한 tacc3 억제제 |
AU2022256380A1 (en) * | 2021-04-12 | 2023-11-30 | A2A Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
WO2023183520A1 (en) | 2022-03-24 | 2023-09-28 | A2A Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
HUP0400908A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors, their use and pharmaceutical compositions containing them |
CN101679386A (zh) * | 2007-04-13 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的氨基嘧啶类化合物 |
CA2688584A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
EP2674161A1 (en) * | 2010-11-11 | 2013-12-18 | Akron Molecules GmbH | FMO3 inhibitors for treating pain |
CN103622966A (zh) * | 2012-08-24 | 2014-03-12 | 常辉 | 陶扎色替在制备治疗精神分裂症的药物中的用途 |
-
2018
- 2018-11-22 BR BR112020010120-6A patent/BR112020010120A2/pt not_active Application Discontinuation
- 2018-11-22 WO PCT/EP2018/082183 patent/WO2019101843A1/en unknown
- 2018-11-22 CA CA3076444A patent/CA3076444A1/en not_active Abandoned
- 2018-11-22 JP JP2020545870A patent/JP2021504462A/ja active Pending
- 2018-11-22 US US16/764,996 patent/US20200399250A1/en not_active Abandoned
- 2018-11-22 MX MX2020004536A patent/MX2020004536A/es unknown
- 2018-11-22 EP EP18814791.2A patent/EP3672957A1/en not_active Withdrawn
- 2018-11-22 RU RU2020115534A patent/RU2020115534A/ru unknown
- 2018-11-22 CN CN201880068364.XA patent/CN111247139A/zh active Pending
- 2018-11-22 KR KR1020207017424A patent/KR20200090198A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN111247139A (zh) | 2020-06-05 |
WO2019101843A1 (en) | 2019-05-31 |
EP3672957A1 (en) | 2020-07-01 |
KR20200090198A (ko) | 2020-07-28 |
CA3076444A1 (en) | 2019-05-31 |
RU2020115534A (ru) | 2021-11-08 |
US20200399250A1 (en) | 2020-12-24 |
BR112020010120A2 (pt) | 2020-11-10 |
JP2021504462A (ja) | 2021-02-15 |
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