MX2020004319A - Variantes de beta-lactamasas. - Google Patents

Variantes de beta-lactamasas.

Info

Publication number
MX2020004319A
MX2020004319A MX2020004319A MX2020004319A MX2020004319A MX 2020004319 A MX2020004319 A MX 2020004319A MX 2020004319 A MX2020004319 A MX 2020004319A MX 2020004319 A MX2020004319 A MX 2020004319A MX 2020004319 A MX2020004319 A MX 2020004319A
Authority
MX
Mexico
Prior art keywords
improved
beta
activity
isolated polypeptide
stability
Prior art date
Application number
MX2020004319A
Other languages
English (en)
Inventor
Gunzburg Jean De
Jean - Denis DOCQUIER
Original Assignee
Da Volterra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Da Volterra filed Critical Da Volterra
Publication of MX2020004319A publication Critical patent/MX2020004319A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02006—Beta-lactamase (3.5.2.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un polipéptido aislado que tiene actividad betalactámica y secuencias de ácido nucleico que codifican el polipéptido. El polipéptido aislado de la invención es una variante de VIM-2 con propiedades mejoradas tales como estabilidad de proteasa mejorada, estabilidad en medio intestinal, actividad mejorada contra uno o más antibióticos, actividad específica mejorada y/o producción mejorada en una célula hospedante.
MX2020004319A 2017-10-25 2018-10-24 Variantes de beta-lactamasas. MX2020004319A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17198414 2017-10-25
PCT/EP2018/079223 WO2019081614A1 (en) 2017-10-25 2018-10-24 VARIANTS OF BETA-LACTAMASE

Publications (1)

Publication Number Publication Date
MX2020004319A true MX2020004319A (es) 2020-10-12

Family

ID=60331400

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004319A MX2020004319A (es) 2017-10-25 2018-10-24 Variantes de beta-lactamasas.

Country Status (10)

Country Link
US (2) US11365403B2 (es)
EP (1) EP3701022B1 (es)
JP (1) JP7223015B2 (es)
KR (1) KR20200074982A (es)
CN (1) CN111247246A (es)
BR (1) BR112020007974A2 (es)
CA (1) CA3077603A1 (es)
IL (1) IL273728A (es)
MX (1) MX2020004319A (es)
WO (1) WO2019081614A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11365403B2 (en) * 2017-10-25 2022-06-21 Da Volterra Beta-lactamase variants

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI920206A0 (fi) 1992-01-17 1992-01-17 Pekka Untamo Heino Medicinsk anvaendning, medicinskt foerfarande och preparat.
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DE4422198C2 (de) 1994-06-24 1997-08-28 Audi Ag Verfahren zum Steuern der elektrischen Beheizung eines Katalysators
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
FR2843302B1 (fr) 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
EP2407433A1 (en) 2010-07-15 2012-01-18 Da Volterra Methods for the inactivation of antibiotics
CN102757950A (zh) * 2011-04-25 2012-10-31 天津市国际生物医药联合研究院 超级细菌新德里金属依赖型β-内酰胺酶NDM-1的表达纯化及β-内酰胺酶NDM-1的晶体结构
CN107148473B (zh) * 2014-10-08 2021-08-06 合成生物制品有限公司 β-内酰胺酶制剂及其用途
EP3420078B1 (en) * 2016-02-23 2022-05-25 Da Volterra Beta-lactamase variants
US10988749B2 (en) * 2016-02-23 2021-04-27 Da Volterra Beta-lactamase variants
US11365403B2 (en) * 2017-10-25 2022-06-21 Da Volterra Beta-lactamase variants

Also Published As

Publication number Publication date
KR20200074982A (ko) 2020-06-25
EP3701022B1 (en) 2023-03-01
US20220356459A1 (en) 2022-11-10
JP2021501603A (ja) 2021-01-21
BR112020007974A2 (pt) 2020-10-27
JP7223015B2 (ja) 2023-02-15
CA3077603A1 (en) 2019-05-02
US11365403B2 (en) 2022-06-21
US20200318094A1 (en) 2020-10-08
WO2019081614A1 (en) 2019-05-02
EP3701022A1 (en) 2020-09-02
IL273728A (en) 2020-05-31
CN111247246A (zh) 2020-06-05

Similar Documents

Publication Publication Date Title
EP4219704A3 (en) Aprl-clade protease variants and uses thereof
MX2023010757A (es) Variantes de proteasa y sus usos.
MY197415A (en) Functional expression of monooxygenase and methods of use
BR112016003256A2 (pt) micro-organismos modificados para usar fontes não convencionais de fósforo ou enxofre
BR112018011073A2 (pt) anticorpos antimiostatina, polipeptídeos contendo regiões fc variantes e métodos de utilização
BR112018073628A2 (pt) anticorpos antimiostatina e métodos de utilização
EP4234693A3 (en) Bacillus gibsonii-clade serine proteases
MX2023001119A (es) Variantes de enzimas y polinucleotidos que las codifican.
BR112016002038A2 (pt) Variantes de enzimas
MX2015004088A (es) Proteasas modificadas con inteina, su produccion y aplicaciones industriales.
AR096270A1 (es) Composiciones detergentes
MX2014013329A (es) Variantes de enzimas mejoradas.
WO2016022377A3 (en) Methods for modulating the glycosylation profile of recombinant proteins using dissolved oxygen
MX2016003737A (es) Microorganismo recombinante para la mejora de produccion de productos quimicos finos.
MY193287A (en) Recombinant microorganism for improved production of fine chemicals
MX2016011745A (es) Variantes de hppd y metodos de uso.
AR100606A1 (es) Variantes de lipasas y polinucleótidos que las codifican
IN2014DN10710A (es)
MX2018011980A (es) 3-epimerasa y polinucleotido que la codifica.
AR101147A1 (es) Composiciones y métodos que comprenden una variante de xilanasa
BR112015021960A2 (pt) Células hospedeiras e métodos de uso
EA201791118A1 (ru) Кодон-оптимизированный полинуклеотид для экспрессии crmна высоком уровне
AR102950A1 (es) Variantes de lipasa y polinucleótidos que las codifican
CL2018000164A1 (es) Vector recombinante del virus orf.
BR112018074437A2 (pt) cepa de bacillus licheniformis com atividade probiótica