MX2020004285A - Proceso para preparar el benzotiofen-2-il boronato. - Google Patents

Proceso para preparar el benzotiofen-2-il boronato.

Info

Publication number
MX2020004285A
MX2020004285A MX2020004285A MX2020004285A MX2020004285A MX 2020004285 A MX2020004285 A MX 2020004285A MX 2020004285 A MX2020004285 A MX 2020004285A MX 2020004285 A MX2020004285 A MX 2020004285A MX 2020004285 A MX2020004285 A MX 2020004285A
Authority
MX
Mexico
Prior art keywords
benzothiophen
boronate
preparing
empty
preparing benzothiophen
Prior art date
Application number
MX2020004285A
Other languages
English (en)
Inventor
Johannes Platzek
Jörg Gries
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2020004285A publication Critical patent/MX2020004285A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un proceso para preparar el benzotiofen-2-il boronato de la fórmula (VI): Ver formula que sirve como intermediario para la producción de medicamentos y para la producción de medicamentos para el tratamiento y/o la profilaxis de trastornos proliferativos, como, por ejemplo, cáncer y enfermedades tumorales.
MX2020004285A 2017-10-25 2018-10-18 Proceso para preparar el benzotiofen-2-il boronato. MX2020004285A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17198336 2017-10-25
PCT/EP2018/078586 WO2019081346A1 (en) 2017-10-25 2018-10-18 PROCESS FOR THE PREPARATION OF BENZOTHIOPHEN-2YL BORONATE

Publications (1)

Publication Number Publication Date
MX2020004285A true MX2020004285A (es) 2020-07-29

Family

ID=60293714

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004285A MX2020004285A (es) 2017-10-25 2018-10-18 Proceso para preparar el benzotiofen-2-il boronato.

Country Status (20)

Country Link
US (2) US11274110B2 (es)
EP (1) EP3700894A1 (es)
JP (1) JP2021500392A (es)
KR (1) KR20200074128A (es)
CN (1) CN111225907B (es)
AR (1) AR113793A1 (es)
AU (1) AU2018354780A1 (es)
BR (1) BR112020008063A2 (es)
CA (1) CA3084755A1 (es)
CL (1) CL2020001093A1 (es)
CO (1) CO2020004984A2 (es)
IL (1) IL273952A (es)
JO (1) JOP20200090A1 (es)
MX (1) MX2020004285A (es)
PE (1) PE20211268A1 (es)
SG (1) SG11202002199RA (es)
TW (1) TWI784074B (es)
UA (1) UA126592C2 (es)
UY (1) UY37949A (es)
WO (1) WO2019081346A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
AU2021353004A1 (en) 2020-09-30 2023-04-13 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030355A1 (it) * 2003-07-18 2005-01-19 Sigma Tau Ind Farmaceuti Composti ad attivita' citotossica derivati della combretastatina.
AU2008216382A1 (en) * 2007-02-12 2008-08-21 Array Biopharma, Inc. Novel inhibitors hepatitis C virus replication
CA2739058A1 (en) * 2008-10-15 2010-04-22 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative and use thereof for medical purposes
UY34484A (es) 2011-12-15 2013-07-31 Bayer Ip Gmbh Benzotienilo-pirrolotriazinas disustituidas y sus usos
EP2791143B1 (en) * 2011-12-15 2016-02-24 Bayer Intellectual Property GmbH Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment of cancer

Also Published As

Publication number Publication date
WO2019081346A1 (en) 2019-05-02
US11274110B2 (en) 2022-03-15
RU2020115600A (ru) 2021-11-25
CN111225907A (zh) 2020-06-02
AU2018354780A1 (en) 2020-04-09
JOP20200090A1 (ar) 2020-05-03
TWI784074B (zh) 2022-11-21
PE20211268A1 (es) 2021-07-19
TW201925211A (zh) 2019-07-01
JP2021500392A (ja) 2021-01-07
US20220356194A1 (en) 2022-11-10
UA126592C2 (uk) 2022-11-02
IL273952A (en) 2020-05-31
US20200339606A1 (en) 2020-10-29
CL2020001093A1 (es) 2020-10-23
SG11202002199RA (en) 2020-04-29
UY37949A (es) 2019-05-31
KR20200074128A (ko) 2020-06-24
RU2020115600A3 (es) 2022-03-29
CN111225907B (zh) 2023-05-26
CO2020004984A2 (es) 2020-05-05
AR113793A1 (es) 2020-06-10
EP3700894A1 (en) 2020-09-02
BR112020008063A2 (pt) 2020-11-03
CA3084755A1 (en) 2019-05-02

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