MX2020003081A - Metodos para inhibir la conversion de colina en trimetilamina (tma). - Google Patents

Metodos para inhibir la conversion de colina en trimetilamina (tma).

Info

Publication number
MX2020003081A
MX2020003081A MX2020003081A MX2020003081A MX2020003081A MX 2020003081 A MX2020003081 A MX 2020003081A MX 2020003081 A MX2020003081 A MX 2020003081A MX 2020003081 A MX2020003081 A MX 2020003081A MX 2020003081 A MX2020003081 A MX 2020003081A
Authority
MX
Mexico
Prior art keywords
tma
trimethylamine
choline
methods
inhibiting conversion
Prior art date
Application number
MX2020003081A
Other languages
English (en)
Inventor
Jose Carlos Garcia-Garcia
George Franklin Gerberick
Stanley Leon HAZEN
Xiaodong Gu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX2020003081A publication Critical patent/MX2020003081A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método para inhibir la conversión de colina en trimetilamina (TMA) y reducir la TMAO en un individuo al proporcionar una composición que comprende un compuesto expuesto en la Fórmula (I): (ver Fórmula).
MX2020003081A 2017-10-02 2018-10-02 Metodos para inhibir la conversion de colina en trimetilamina (tma). MX2020003081A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762567010P 2017-10-02 2017-10-02
PCT/US2018/053929 WO2019070678A1 (en) 2017-10-02 2018-10-02 METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA)

Publications (1)

Publication Number Publication Date
MX2020003081A true MX2020003081A (es) 2022-03-07

Family

ID=63963529

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003081A MX2020003081A (es) 2017-10-02 2018-10-02 Metodos para inhibir la conversion de colina en trimetilamina (tma).

Country Status (9)

Country Link
US (1) US10849866B2 (es)
EP (1) EP3522927B1 (es)
CN (1) CN111344016B (es)
AU (1) AU2018345749B2 (es)
BR (1) BR112020006085A2 (es)
CA (1) CA3076235C (es)
MX (1) MX2020003081A (es)
PL (1) PL3522927T3 (es)
WO (1) WO2019070678A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11331280B2 (en) 2018-11-06 2022-05-17 The Procter & Gamble Company Methods for inhibiting conversion of choline to trimethylamine (TMA)
AU2019395020A1 (en) * 2018-12-06 2021-06-17 Senda Biosciences, Inc. Decarboxylase inhibitors for treating Parkinson's disease
CN112029818A (zh) * 2020-09-18 2020-12-04 中国药科大学 一种利用微生物筛选三甲胺裂解酶抑制剂的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542826B1 (de) 1966-06-01 1971-04-08 Basf Ag Sulfoniumverbindungen und deren Verwendung
FR1559102A (es) 1968-01-23 1969-03-07
US3644531A (en) 1968-08-13 1972-02-22 Sankyo Co 2-propynylsulfonium salts
US3651222A (en) 1969-09-15 1972-03-21 Monsanto Co Nematocidal use of substituted dimethylsulfonium tetraphenylborates
DE2331185A1 (de) 1973-06-19 1975-01-16 Bayer Ag Mittel zur regulierung des pflanzenwachstums
DE69310401T2 (de) 1992-02-07 1997-08-21 Toyo Ink Mfg Co (Oxo)Sulfoniumkomplex, diese enthaltende polymerisierbare Zusammensetzung und Verfahren zur Polymerisation
JP2006528648A (ja) * 2003-07-24 2006-12-21 ザ クイーンズ メディカル センター アルキル化剤の調製及び使用
JP4999043B2 (ja) 2006-02-13 2012-08-15 株式会社Ａｄｅｋａ スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物
AU2007230989A1 (en) * 2006-03-22 2007-10-04 President And Fellows Of Harvard College Methods and compositions for treating hypercholesterolemia and atherosclerosis
US9423405B2 (en) 2007-12-05 2016-08-23 The Cleveland Clinic Foundation Trimethylamine compounds as risk predictors of cardiovascular disease
CA2876177C (en) 2012-06-11 2022-06-14 The Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis
EP3383377B1 (en) * 2015-12-01 2024-04-17 The Procter & Gamble Company Compounds and methods for inhibiting production of trimethylamine
EP3478276B1 (en) 2016-06-29 2021-10-06 The Procter & Gamble Company Methods for inhibiting conversion of choline to trimethylamine (tma)

Also Published As

Publication number Publication date
EP3522927A1 (en) 2019-08-14
EP3522927B1 (en) 2020-11-25
CA3076235A1 (en) 2019-04-11
AU2018345749A1 (en) 2020-04-09
US20190099390A1 (en) 2019-04-04
PL3522927T3 (pl) 2021-06-28
CN111344016B (zh) 2022-04-05
WO2019070678A1 (en) 2019-04-11
US10849866B2 (en) 2020-12-01
CA3076235C (en) 2022-06-21
BR112020006085A2 (pt) 2020-09-29
CN111344016A (zh) 2020-06-26
AU2018345749B2 (en) 2021-03-11

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