MX2019012667A - Metodos de interrupcion de gen dirigido y composiciones inmunogenicas. - Google Patents
Metodos de interrupcion de gen dirigido y composiciones inmunogenicas.Info
- Publication number
- MX2019012667A MX2019012667A MX2019012667A MX2019012667A MX2019012667A MX 2019012667 A MX2019012667 A MX 2019012667A MX 2019012667 A MX2019012667 A MX 2019012667A MX 2019012667 A MX2019012667 A MX 2019012667A MX 2019012667 A MX2019012667 A MX 2019012667A
- Authority
- MX
- Mexico
- Prior art keywords
- immunogenic compositions
- genes
- pathogens
- targeted gene
- gene disruption
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0233—Rickettsiales, e.g. Anaplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a la interrupción dirigida de un gen específico y su restauración subsecuente en bacterias intracelulares obligadas sigue siendo extremadamente desafiante debido a su requerimiento absoluto para residencia dentro de una célula hospedera para replicarse. Aquí, las mutaciones de intercambio alélico dirigido se crearon para inactivar dos genes y después para restaurar uno de los dos genes de un patógeno rickettsial, Ehrlichia chaffeensis. Estos métodos también fueron exitosamente utilizados en Ehrlichia canis y Anaplasma phagocyophilum. Los patógenos mutados resultantes son útiles en las composiciones inmunogénicas para reducir la incidencia de, o severidad de la infección con patógenos rickettsiales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762491896P | 2017-04-28 | 2017-04-28 | |
PCT/US2018/030302 WO2018201153A1 (en) | 2017-04-28 | 2018-04-30 | Targeted gene disruption methods and immunogenic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019012667A true MX2019012667A (es) | 2020-01-21 |
Family
ID=63918799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019012667A MX2019012667A (es) | 2017-04-28 | 2018-04-30 | Metodos de interrupcion de gen dirigido y composiciones inmunogenicas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US11541108B2 (es) |
EP (1) | EP3615049A4 (es) |
JP (1) | JP2020517722A (es) |
KR (1) | KR20200003039A (es) |
CN (1) | CN110913877A (es) |
AU (1) | AU2018256922A1 (es) |
BR (1) | BR112019022325A2 (es) |
CA (1) | CA3060320A1 (es) |
MX (1) | MX2019012667A (es) |
WO (1) | WO2018201153A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112175955B (zh) * | 2020-10-29 | 2022-05-24 | 西南大学 | 一种在植物花粉中特异表达的强启动子cp09及其应用 |
AU2023224276A1 (en) * | 2022-02-24 | 2024-08-22 | Kansas State University Research Foundation | Anaplasma vaccines and methods of use thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6653128B2 (en) * | 1996-10-17 | 2003-11-25 | University Of Florida | Nucleic acid vaccines against rickettsial diseases and methods of use |
US7335754B2 (en) * | 1999-07-21 | 2008-02-26 | Cornell Research Foundation, Inc. | Ehrlichia canis genes and vaccines |
NZ532634A (en) * | 2001-11-01 | 2006-09-29 | Res Dev Foundation | DNA encoding disulfide bond formation (Dsb) proteins from bacterial species of the genus Ehrlichia, such as Ehrlichia chaffeensis and Ehrlichia canis disulfide bond formation proteins. |
WO2011041886A1 (en) * | 2009-10-07 | 2011-04-14 | University Of Victoria Innovation And Development Corporation | Vaccines comprising heat-sensitive transgenes |
AU2013341242B2 (en) * | 2012-11-06 | 2018-06-28 | Aduro Biotech, Inc. | Facultatively attenuated bacterial species and methods of preparation and use thereof |
WO2014113541A1 (en) * | 2013-01-16 | 2014-07-24 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Attenuated chlamydia vaccine |
US20180021421A1 (en) * | 2015-01-19 | 2018-01-25 | Kansas State University Research Foundation | Attenuated vaccines to protect against tick-borne ehrlichia species infections |
-
2018
- 2018-04-30 CA CA3060320A patent/CA3060320A1/en active Pending
- 2018-04-30 KR KR1020197035037A patent/KR20200003039A/ko not_active Application Discontinuation
- 2018-04-30 CN CN201880040097.5A patent/CN110913877A/zh active Pending
- 2018-04-30 AU AU2018256922A patent/AU2018256922A1/en active Pending
- 2018-04-30 MX MX2019012667A patent/MX2019012667A/es unknown
- 2018-04-30 US US16/609,097 patent/US11541108B2/en active Active
- 2018-04-30 EP EP18789954.7A patent/EP3615049A4/en active Pending
- 2018-04-30 BR BR112019022325-8A patent/BR112019022325A2/pt unknown
- 2018-04-30 JP JP2019558579A patent/JP2020517722A/ja active Pending
- 2018-04-30 WO PCT/US2018/030302 patent/WO2018201153A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU2018256922A1 (en) | 2019-11-28 |
BR112019022325A2 (pt) | 2020-05-26 |
EP3615049A1 (en) | 2020-03-04 |
KR20200003039A (ko) | 2020-01-08 |
WO2018201153A1 (en) | 2018-11-01 |
JP2020517722A (ja) | 2020-06-18 |
US11541108B2 (en) | 2023-01-03 |
EP3615049A4 (en) | 2020-12-30 |
CN110913877A (zh) | 2020-03-24 |
US20200188498A1 (en) | 2020-06-18 |
CA3060320A1 (en) | 2018-11-01 |
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