MX2019012606A - Celulas t que redirigen anticuerpos biespecificos para el tratamiento de canceres positivos a egfr. - Google Patents

Celulas t que redirigen anticuerpos biespecificos para el tratamiento de canceres positivos a egfr.

Info

Publication number
MX2019012606A
MX2019012606A MX2019012606A MX2019012606A MX2019012606A MX 2019012606 A MX2019012606 A MX 2019012606A MX 2019012606 A MX2019012606 A MX 2019012606A MX 2019012606 A MX2019012606 A MX 2019012606A MX 2019012606 A MX2019012606 A MX 2019012606A
Authority
MX
Mexico
Prior art keywords
cd3xegfr
bispecific antibodies
seq
treatment
egfr
Prior art date
Application number
MX2019012606A
Other languages
English (en)
Inventor
STUTZ Cian
Lissilaa Rami
Blein Stanislas
Original Assignee
Ichnos Sciences SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ichnos Sciences SA filed Critical Ichnos Sciences SA
Publication of MX2019012606A publication Critical patent/MX2019012606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona a anticuerpos biespecíficos que se unen a CD3 y EGFR simultáneamente. Esta clase de anticuerpo ha demostrado por los inventores ser útil en el tratamiento de tumores EGFR al redirigir las células T y formar una sinapsis inmune entre las células T activadas y EGFR que expresan células tumorales, llevando a mayores niveles de matanza de células tumolares que expresan EGFR. En particular la presente invención se relaciona a anticuerpos biespecíficos de CD3xEGFR_SF4 (SEQ ID NO: 4, 5 y 9), CD3xEGFR_SD1 (SEQ ID NO: 1, 2 y 10) y CD3xEGFR_SD2 (SEQ ID NO: 11, 10 y 2).
MX2019012606A 2017-04-24 2018-04-24 Celulas t que redirigen anticuerpos biespecificos para el tratamiento de canceres positivos a egfr. MX2019012606A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17167709 2017-04-24
PCT/EP2018/060488 WO2018197502A1 (en) 2017-04-24 2018-04-24 T cell redirecting bispecific antibodies for the treatment of egfr positive cancers

Publications (1)

Publication Number Publication Date
MX2019012606A true MX2019012606A (es) 2019-12-02

Family

ID=58632245

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012606A MX2019012606A (es) 2017-04-24 2018-04-24 Celulas t que redirigen anticuerpos biespecificos para el tratamiento de canceres positivos a egfr.

Country Status (11)

Country Link
US (1) US20230159661A1 (es)
EP (1) EP3615571A1 (es)
JP (1) JP2020517659A (es)
KR (1) KR20200002886A (es)
CN (1) CN110831968A (es)
AU (1) AU2018259039A1 (es)
CA (1) CA3060190A1 (es)
EA (1) EA201992143A1 (es)
MX (1) MX2019012606A (es)
SG (2) SG11201909498XA (es)
WO (1) WO2018197502A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201603244VA (en) * 2013-11-04 2016-05-30 Glenmark Pharmaceuticals Sa Production of t cell retargeting hetero-dimeric immunoglobulins
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
WO2022178040A1 (en) * 2021-02-16 2022-08-25 City Of Hope Truncated domain iv egfr and uses thereof
US20230295310A1 (en) * 2022-03-20 2023-09-21 Abcellera Biologics Inc. CD3 T-Cell Engagers and Methods of Use
WO2023192514A1 (en) * 2022-03-30 2023-10-05 Pinetree Therapeutics, Inc. Bispecific antibodies comprising an nrp1 binding domain and methods of use thereof
CN114621351B (zh) * 2022-04-27 2023-01-03 华羊生物技术股份有限公司 多特异性抗体及其治疗癌症的用途
WO2024030341A1 (en) * 2022-07-30 2024-02-08 Pinetree Therapeutics, Inc. Compositions for targeted lysosomal degradaton and methods of use thereof
CN117305248A (zh) * 2022-09-09 2023-12-29 复星凯特生物科技有限公司 抗EGFR和cMet双特异性嵌合抗原受体及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009010611A (es) * 2007-04-03 2010-03-26 Micromet Ag Enlazadores biespecificos, especificos para especies.
US10329350B2 (en) * 2012-12-26 2019-06-25 Industrial Technology Research Institute Method for producing a multivalent fab fragment with collagen-like peptide
MX2015010843A (es) * 2013-02-26 2016-04-04 Roche Glycart Ag Moleculas biespecificas de union al antigeno que activan celulas t.
WO2014170063A1 (en) * 2013-04-19 2014-10-23 Covagen Ag Novel bispecific binding molecules with antitumoral activity
CN104341504B (zh) * 2013-08-06 2017-10-24 百奥泰生物科技(广州)有限公司 双特异性抗体
SG11201603244VA (en) * 2013-11-04 2016-05-30 Glenmark Pharmaceuticals Sa Production of t cell retargeting hetero-dimeric immunoglobulins
MA40894A (fr) * 2014-11-04 2017-09-12 Glenmark Pharmaceuticals Sa Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production
CN104774268B (zh) * 2015-01-21 2018-09-28 武汉友芝友生物制药有限公司 一种双特异性抗体egfr×cd3的构建及应用

Also Published As

Publication number Publication date
JP2020517659A (ja) 2020-06-18
SG11201909498XA (en) 2019-11-28
EP3615571A1 (en) 2020-03-04
SG10201912545PA (en) 2020-02-27
EA201992143A1 (ru) 2020-03-13
AU2018259039A1 (en) 2019-11-07
US20230159661A1 (en) 2023-05-25
KR20200002886A (ko) 2020-01-08
CN110831968A (zh) 2020-02-21
WO2018197502A1 (en) 2018-11-01
CA3060190A1 (en) 2018-11-01

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