MX2019011980A - Aislamiento de cannabinoides puros a partir de cannabis. - Google Patents

Aislamiento de cannabinoides puros a partir de cannabis.

Info

Publication number
MX2019011980A
MX2019011980A MX2019011980A MX2019011980A MX2019011980A MX 2019011980 A MX2019011980 A MX 2019011980A MX 2019011980 A MX2019011980 A MX 2019011980A MX 2019011980 A MX2019011980 A MX 2019011980A MX 2019011980 A MX2019011980 A MX 2019011980A
Authority
MX
Mexico
Prior art keywords
cannabinoids
sup
cannabis
isolation
thc
Prior art date
Application number
MX2019011980A
Other languages
English (en)
Inventor
Wassem Gul
Mohamed M Radwan
Amira Samir Wanas
Mahmoud A Elsohly
Original Assignee
Univ Mississippi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mississippi filed Critical Univ Mississippi
Publication of MX2019011980A publication Critical patent/MX2019011980A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/28—Cannabaceae, e.g. cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/74—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/82—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

El Aº-tetrahidrocannabinol (Aº-THC o THC) y el cannabidiol (CBD) son componentes principales de la planta de Cannabis que tienen propiedades farmacológicas con un valor terapéutico potencial. Esta invención está dirigida a procesos para el aislamiento a gran escala de estos dos y otros cannabinoides de la planta Cannabis sativa. Esto se logra mediante el descubrimiento de que los ésteres de aminoácidos protegidos de los cannabinoides son más fáciles de separar usando cromatografía en columna de sílice en fase normal. La hidrólisis de base suave de los ésteres regenera los cannabinoides libres en forma purificada. La invención también es aplicable al aislamiento de otros cannabinoides a partir de extractos de Cannabis.
MX2019011980A 2017-04-05 2018-04-04 Aislamiento de cannabinoides puros a partir de cannabis. MX2019011980A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762481884P 2017-04-05 2017-04-05
PCT/US2018/026126 WO2018187500A1 (en) 2017-04-05 2018-04-04 Isolation of pure cannabinoids from cannabis

Publications (1)

Publication Number Publication Date
MX2019011980A true MX2019011980A (es) 2020-07-29

Family

ID=63713301

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011980A MX2019011980A (es) 2017-04-05 2018-04-04 Aislamiento de cannabinoides puros a partir de cannabis.

Country Status (5)

Country Link
US (1) US11117852B2 (es)
EP (1) EP3599831A4 (es)
CA (1) CA3059227A1 (es)
MX (1) MX2019011980A (es)
WO (1) WO2018187500A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
WO2019152736A1 (en) 2018-01-31 2019-08-08 Canopy Holdings, LLC Hemp powder
CN112969452A (zh) 2018-04-09 2021-06-15 艾乐文特科学公司 用于治疗动物疼痛的大麻提取物
WO2020028198A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
WO2020117688A2 (en) * 2018-12-04 2020-06-11 Orochem Technologies Inc. Process for purifying tetrahydrocannabinol using a chromatographic stationary phase
US10471113B1 (en) 2019-03-26 2019-11-12 Jenny's Rose, LLC Producing cannabis extracts via selective decarboxylation
US10717717B1 (en) 2019-03-26 2020-07-21 Jenny's Rose, LLC Active fraction from therapeutic cannabis plant extracts
US11401226B2 (en) * 2019-05-17 2022-08-02 Mile High Labs, Inc. Systems and methods for refining cannabidiol
US20220242810A1 (en) * 2019-06-14 2022-08-04 Purisys Llc Crystalline cannabigerol
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
CA3148765A1 (en) * 2019-07-31 2021-02-04 Canopy Growth Corporation Separation of cannabinoids from cannabinoid mixtures by derivatization
WO2021035091A1 (en) * 2019-08-20 2021-02-25 Canopy Holdings, LLC Remediated oils
US10946054B1 (en) 2019-10-08 2021-03-16 Jenny's Rose, LLC Therapeutic cannabis extracts
US11291699B1 (en) 2019-12-13 2022-04-05 Delmarva Hemp, LLC Method for solvent-free extraction and concentration of full spectrum of cannabinoids in a carrier oil
US10919828B1 (en) * 2020-02-14 2021-02-16 Aicardo Roa-Espinosa Process for manufacturing cannabidiol
US11731949B2 (en) 2020-04-09 2023-08-22 Jenny's Rose, LLC Apparatus for decarboxylation of cannabis extracts
CN112285233B (zh) * 2020-10-22 2022-05-13 三明海关综合技术服务中心 一种检测油脂中大麻素类新精神活性物质的前处理方法
CN112645802A (zh) * 2020-12-10 2021-04-13 云南昆船环保技术有限公司 一种有效去除四氢大麻酚的大麻二酚广谱油制备方法
EP4263515A1 (en) * 2020-12-18 2023-10-25 Finley, Matthew Havis Facile purification of cannabinoid acids
CN115583933B (zh) * 2022-10-31 2024-02-06 暨明医药科技（苏州）有限公司 一种高纯度四氢大麻素同系物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60184098A (ja) 1984-03-02 1985-09-19 Suntory Ltd 新規なペプチド及びこれを有効成分とする利尿剤
DE69735811T2 (de) * 1996-10-30 2006-12-28 Schering Corp. Piperazinoderivate als neurokinin-antagonisten
US6365416B1 (en) * 1998-10-26 2002-04-02 The University Of Mississippi Method of preparing delta-9-tetrahydrocannabinol
US20080306285A1 (en) * 2007-04-27 2008-12-11 Alexza Pharmaceuticals, Inc. Heat-Labile Prodrugs
EP2352497B1 (en) * 2008-10-31 2017-02-22 University of Mississippi Process of preparation of delta-9-thc-amino acid esters

Also Published As

Publication number Publication date
EP3599831A4 (en) 2020-12-09
US11117852B2 (en) 2021-09-14
US20200039908A1 (en) 2020-02-06
WO2018187500A1 (en) 2018-10-11
CA3059227A1 (en) 2018-10-11
EP3599831A1 (en) 2020-02-05

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