MX2019011101A - Anticuerpo que se une especificamente a muc1 y uso del mismo. - Google Patents

Anticuerpo que se une especificamente a muc1 y uso del mismo.

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Publication number
MX2019011101A
MX2019011101A MX2019011101A MX2019011101A MX2019011101A MX 2019011101 A MX2019011101 A MX 2019011101A MX 2019011101 A MX2019011101 A MX 2019011101A MX 2019011101 A MX2019011101 A MX 2019011101A MX 2019011101 A MX2019011101 A MX 2019011101A
Authority
MX
Mexico
Prior art keywords
antibody
muc1
antigen
binding fragment
binding
Prior art date
Application number
MX2019011101A
Other languages
English (en)
Inventor
Ho Il Choi
Kyung Duk Moon
Original Assignee
Peptron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptron Inc filed Critical Peptron Inc
Priority claimed from PCT/KR2018/003267 external-priority patent/WO2018174544A2/ko
Publication of MX2019011101A publication Critical patent/MX2019011101A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/77—Internalization into the cell
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4725—Mucins, e.g. human intestinal mucin

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
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Abstract

La presente invención se refiere a un anticuerpo anti-MUC1 que se une específicamente a Mucina 1 (MUC1) y un uso del mismo y, más particularmente, a un anticuerpo anti-MUC1 o un fragmento de unión a antígeno del mismo, un conjugado anticuerpo-fármaco o anticuerpo biespecífico que comprende el anticuerpo o un fragmento de unión a antígeno del mismo, una composición farmacéutica para la prevención o el tratamiento del cáncer, que comprende el mismo conjugado o anticuerpo biespecífico, y un ácido nucleico que codifica el mismo anticuerpo o un fragmento de unión a antígeno del mismo, un vector y una célula huésped, ambos portadores del mismo ácido nucleico, y un método para preparar un anticuerpo anti??MUC1 o un fragmento de unión a antígeno del mismo, usando el mismo vector y la célula huésped. De acuerdo con la presente invención, un anticuerpo que se une específicamente a MUC1 o un fragmento de unión a antígeno del mismo muestra una fuerza de unión y afinidad sobresalientes a MUC1 y un conjugado anticuerpo-fármaco en el que el anticuerpo o un fragmento de unión a antígeno del mismo se conjuga con un medicamento puede unirse específicamente a una célula que expresa MUC1 para transferir específica o selectivamente el fármaco con eficacia. Por lo tanto, el anticuerpo anti-MUC1 y el conjugado anticuerpo-fármaco de acuerdo con la presente invención pueden aplicarse de manera útil al tratamiento de una enfermedad relacionada con MUC1, por ejemplo, cáncer.
MX2019011101A 2017-03-21 2018-03-21 Anticuerpo que se une especificamente a muc1 y uso del mismo. MX2019011101A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20170035622 2017-03-21
KR1020180032592A KR102127421B1 (ko) 2017-03-21 2018-03-21 Muc1에 특이적으로 결합하는 항체 및 그의 용도
PCT/KR2018/003267 WO2018174544A2 (ko) 2017-03-21 2018-03-21 Muc1에 특이적으로 결합하는 항체 및 그의 용도

Publications (1)

Publication Number Publication Date
MX2019011101A true MX2019011101A (es) 2020-07-14

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MX2019011101A MX2019011101A (es) 2017-03-21 2018-03-21 Anticuerpo que se une especificamente a muc1 y uso del mismo.

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US (4) US11472887B2 (es)
EP (2) EP3825328A1 (es)
JP (3) JP7032425B2 (es)
KR (2) KR102127421B1 (es)
CN (1) CN111201240B (es)
AU (3) AU2018238165C1 (es)
BR (1) BR112019019650A2 (es)
CA (1) CA3056582C (es)
IL (1) IL269488B2 (es)
MX (1) MX2019011101A (es)
RU (1) RU2746413C1 (es)
ZA (1) ZA201906813B (es)

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RU2746413C1 (ru) 2017-03-21 2021-04-13 Пептрон, Инк. Антитело, специфически связывающееся с muc1, и его применение
AU2021239078A1 (en) * 2020-03-18 2022-08-11 Biomodifying, Llc Anti-MUC1-Sea Antibodies
KR20220092432A (ko) * 2020-12-24 2022-07-01 주식회사 엘지화학 뮤신 1에 특이적인 폴리펩티드 및 이의 이용
AU2022320714A1 (en) * 2021-07-30 2024-02-08 R.P. Scherer Technologies, Llc Antibody-drug conjugates and methods of use thereof
AU2022333837A1 (en) 2021-08-27 2024-03-14 Peptron, Inc. Novel anti-muc1 antibody and use thereof
CN114028539B (zh) * 2021-09-13 2024-04-26 北京大学 粘蛋白1在抑制冠状病毒中的应用
CN114106110A (zh) * 2021-11-25 2022-03-01 国家纳米科学中心 一种特异性结合muc1蛋白的多肽、靶向载药共递送系统及其制备方法与应用
WO2023140412A1 (ko) * 2022-01-24 2023-07-27 싸이런테라퓨틱스 주식회사 Muc-1에 특이적으로 결합하는 항체 및 이의 용도
CN116554317A (zh) * 2022-01-29 2023-08-08 浙江纳米抗体技术中心有限公司 Muc1结合分子及其应用

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