MX2019010997A - Entrega oral de sustancias fisiologicamente activas. - Google Patents
Entrega oral de sustancias fisiologicamente activas.Info
- Publication number
- MX2019010997A MX2019010997A MX2019010997A MX2019010997A MX2019010997A MX 2019010997 A MX2019010997 A MX 2019010997A MX 2019010997 A MX2019010997 A MX 2019010997A MX 2019010997 A MX2019010997 A MX 2019010997A MX 2019010997 A MX2019010997 A MX 2019010997A
- Authority
- MX
- Mexico
- Prior art keywords
- physiologically active
- active substance
- stomach
- carrier
- active substances
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 9
- 210000002784 stomach Anatomy 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000004211 gastric acid Anatomy 0.000 abstract 2
- 230000003232 mucoadhesive effect Effects 0.000 abstract 2
- 239000003961 penetration enhancing agent Substances 0.000 abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Las realizaciones pueden incluir una composición para la administración oral de medicamentos. La composición puede incluir una sustancia fisiológicamente activa, un compuesto portador, un compuesto mucoadhesivo y un potenciador de la permeación. La sustancia fisiológicamente activa puede ser transportada a través del estómago. La sustancia fisiológicamente activa puede ser estable y no degradarse en el ambiente hostil del jugo gástrico. Para ayudar a proteger la sustancia fisiológicamente activa, esta se mezcla con el vehículo. El vehículo puede ser un líquido insoluble en el jugo gástrico del estómago La sustancia fisiológicamente activa puede ser soluble en el portador. Se puede usar el compuesto mucoadhesivo para promover la adsorción de la sustancia fisiológicamente activa en el revestimiento del estómago. El potenciador de permeación puede facilitar el transporte de la sustancia fisiológicamente activa a través de la pared del estómago.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762475624P | 2017-03-23 | 2017-03-23 | |
US15/922,651 US20180271792A1 (en) | 2017-03-23 | 2018-03-15 | Oral delivery of physiologically active substances |
PCT/US2018/022928 WO2018175250A1 (en) | 2017-03-23 | 2018-03-16 | Oral delivery of physiologically active substances |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010997A true MX2019010997A (es) | 2019-10-17 |
Family
ID=63581994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010997A MX2019010997A (es) | 2017-03-23 | 2018-03-16 | Entrega oral de sustancias fisiologicamente activas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20180271792A1 (es) |
EP (1) | EP3600380A1 (es) |
JP (1) | JP2020511478A (es) |
KR (1) | KR20190126433A (es) |
CN (1) | CN110662550A (es) |
AU (1) | AU2018237678A1 (es) |
BR (1) | BR112019019596A2 (es) |
CA (1) | CA3055421A1 (es) |
MX (1) | MX2019010997A (es) |
RU (1) | RU2019133551A (es) |
WO (1) | WO2018175250A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2964463C (en) | 2014-10-22 | 2024-02-13 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
CN112057619A (zh) * | 2019-06-10 | 2020-12-11 | 苏州兰鼎生物制药有限公司 | 一种具有降血糖作用的药物组合物 |
US20220184166A1 (en) * | 2020-12-10 | 2022-06-16 | Theo Rallis | Discrete phase particles including compounds from olea europaea |
CN113209280B (zh) * | 2021-03-07 | 2022-03-25 | 合肥天汇孵化科技有限公司 | 甲状旁腺激素组合物及其用途 |
CN113053453B (zh) * | 2021-03-15 | 2022-01-04 | 中国农业科学院农业质量标准与检测技术研究所 | 应用转录组学筛选全氟辛烷磺酸毒性枢纽基因和关键信号通路的方法 |
US20230053812A1 (en) * | 2021-07-27 | 2023-02-23 | Aurobindo Pharma Ltd | Stable peptide formulations for oral use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
US6001821A (en) * | 1995-12-19 | 1999-12-14 | Pitha; Josef | Dioxane-substituted cyclodextrin macromolecules and inclusion complexes |
US5935941A (en) * | 1997-10-24 | 1999-08-10 | Pitha; Josef | Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity |
US5830969A (en) * | 1997-05-28 | 1998-11-03 | Dow Corning Corporation | Silyl ester initiators for ring opening polymerization of cyclosiloxanes |
KR100638041B1 (ko) * | 2003-12-24 | 2006-10-23 | 주식회사 삼양사 | 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법 |
US20070281007A1 (en) * | 2004-08-27 | 2007-12-06 | Jacob Jules S | Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs |
JP2008533101A (ja) * | 2005-03-17 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | 肥満の治療において使用するための化合物 |
UA114700C2 (uk) * | 2007-10-16 | 2017-07-25 | Біокон Лімітед | Тверда фармацевтична форма для перорального застосування та процес її виготовлення |
CN102123697B (zh) * | 2008-08-18 | 2015-06-10 | 安特拉贝欧有限公司 | 用于口服给予蛋白质的方法和组合物 |
US10046058B2 (en) * | 2014-12-02 | 2018-08-14 | Rezolute, Inc. | Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates |
-
2018
- 2018-03-15 US US15/922,651 patent/US20180271792A1/en not_active Abandoned
- 2018-03-16 RU RU2019133551A patent/RU2019133551A/ru not_active Application Discontinuation
- 2018-03-16 CA CA3055421A patent/CA3055421A1/en not_active Abandoned
- 2018-03-16 JP JP2019551421A patent/JP2020511478A/ja active Pending
- 2018-03-16 WO PCT/US2018/022928 patent/WO2018175250A1/en unknown
- 2018-03-16 EP EP18770869.8A patent/EP3600380A1/en not_active Withdrawn
- 2018-03-16 AU AU2018237678A patent/AU2018237678A1/en not_active Abandoned
- 2018-03-16 CN CN201880034127.1A patent/CN110662550A/zh active Pending
- 2018-03-16 BR BR112019019596A patent/BR112019019596A2/pt not_active Application Discontinuation
- 2018-03-16 KR KR1020197031178A patent/KR20190126433A/ko unknown
- 2018-03-16 MX MX2019010997A patent/MX2019010997A/es unknown
Also Published As
Publication number | Publication date |
---|---|
RU2019133551A (ru) | 2021-04-23 |
US20180271792A1 (en) | 2018-09-27 |
AU2018237678A1 (en) | 2019-10-03 |
BR112019019596A2 (pt) | 2020-04-22 |
WO2018175250A1 (en) | 2018-09-27 |
EP3600380A1 (en) | 2020-02-05 |
CN110662550A (zh) | 2020-01-07 |
KR20190126433A (ko) | 2019-11-11 |
JP2020511478A (ja) | 2020-04-16 |
CA3055421A1 (en) | 2018-09-27 |
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