MX2019010958A - Methods of treating tumor. - Google Patents

Methods of treating tumor.

Info

Publication number
MX2019010958A
MX2019010958A MX2019010958A MX2019010958A MX2019010958A MX 2019010958 A MX2019010958 A MX 2019010958A MX 2019010958 A MX2019010958 A MX 2019010958A MX 2019010958 A MX2019010958 A MX 2019010958A MX 2019010958 A MX2019010958 A MX 2019010958A
Authority
MX
Mexico
Prior art keywords
subject
antigen
tumor
antibody
tmb
Prior art date
Application number
MX2019010958A
Other languages
Spanish (es)
Inventor
Chang Han
Seshaiyer BHAGAVATHEESWARAN Prabhu
Allan John Botwood Nicholas
Fu Yali
J Geese William
A Green George Iv
HEALEY Diane
Maier Sabine
E Nathan Faith
Oukessou Abderrahim
SELVAGGI Giovanni
Daniel Szustakowski Joseph
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2019010958A publication Critical patent/MX2019010958A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)

Abstract

The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti- PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.
MX2019010958A 2017-03-31 2018-03-30 Methods of treating tumor. MX2019010958A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762479817P 2017-03-31 2017-03-31
US201762582146P 2017-11-06 2017-11-06
PCT/US2018/025518 WO2018183928A1 (en) 2017-03-31 2018-03-30 Methods of treating tumor

Publications (1)

Publication Number Publication Date
MX2019010958A true MX2019010958A (en) 2019-10-17

Family

ID=62067782

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019010958A MX2019010958A (en) 2017-03-31 2018-03-30 Methods of treating tumor.

Country Status (13)

Country Link
US (2) US20210101980A1 (en)
EP (1) EP3601355A1 (en)
JP (1) JP7458188B2 (en)
KR (1) KR20190133213A (en)
CN (1) CN110494450A (en)
AU (1) AU2018243754A1 (en)
BR (1) BR112019019795A2 (en)
CA (1) CA3058175A1 (en)
IL (1) IL269026A (en)
MA (1) MA50056A (en)
MX (1) MX2019010958A (en)
SG (2) SG10202110594UA (en)
WO (1) WO2018183928A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368170B (en) 2015-07-13 2022-04-15 西托姆克斯治疗公司 anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof
MA42626A (en) 2015-08-11 2018-06-20 Open Monoclonal Tech Inc NEW ANTI-PD-1 ANTIBODIES
WO2019075468A1 (en) * 2017-10-15 2019-04-18 Bristol-Myers Squibb Company Methods of treating tumor
JP7351845B2 (en) * 2018-03-23 2023-09-27 ブリストル－マイヤーズ スクイブ カンパニー Antibodies against MICA and/or MICB and their uses
KR20200139724A (en) * 2018-03-30 2020-12-14 브리스톨-마이어스 스큅 컴퍼니 How to treat a tumor
US11640859B2 (en) * 2018-10-17 2023-05-02 Tempus Labs, Inc. Data based cancer research and treatment systems and methods
KR20210081384A (en) 2018-10-23 2021-07-01 브리스톨-마이어스 스큅 컴퍼니 how to treat a tumor
WO2020102674A1 (en) * 2018-11-15 2020-05-22 Personal Genome Diagnostics Inc. Method of improving prediction of response for cancer patients treated with immunotherapy
CN113194995A (en) * 2018-12-12 2021-07-30 免疫医疗有限责任公司 Predicting overall survival of non-small cell lung cancer based on tumor mutation burden of blood
CN113228190B (en) * 2018-12-23 2024-06-11 豪夫迈·罗氏有限公司 Systems and methods for classifying and/or identifying cancer subtypes
WO2020198676A1 (en) * 2019-03-28 2020-10-01 Bristol-Myers Squibb Company Methods of treating tumor
GB201904555D0 (en) * 2019-04-01 2019-05-15 Univ Manchester Biomarkers and uses thereof
CN110229894B (en) * 2019-05-21 2020-09-08 武汉大学 Gene combination and application thereof in preparation of reagent for predicting prognosis of patient receiving immune checkpoint inhibitor treatment
EP3982954A4 (en) * 2019-06-14 2024-01-03 The Trustees of Columbia University in the City of New York Nt5c2 inhibitors for the treatment of chemotherapy-resistant acute lymphoblastic leukemia
MX2022001812A (en) 2019-08-12 2022-03-11 Regeneron Pharma Macrophage stimulating 1 receptor (mst1r) variants and uses thereof.
JP2022551921A (en) * 2019-10-09 2022-12-14 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル DNA Copy Number Abnormalities (CNAs) for Determining Cancer Phenotypes
CN110927389B (en) * 2019-11-29 2021-07-16 中国科学院苏州生物医学工程技术研究所 Cancer biomarker and application
CN111269979A (en) * 2020-02-06 2020-06-12 至本医疗科技（上海）有限公司 Application of ARID1B gene variation in prediction of sensitivity of lung adenocarcinoma patient to immune checkpoint inhibitor therapy
CN110923329B (en) * 2020-02-06 2020-05-12 至本医疗科技（上海）有限公司 Application of FGFR4 point mutation in prediction of sensitivity of non-small cell lung cancer patient to immune checkpoint inhibitor therapy
US20230193399A1 (en) * 2020-05-21 2023-06-22 Astrazeneca Ab Tumor mutational burden associated with sensitivity to immunotherapy in locally advanced or metastatic urothelial carcinoma
TWI788188B (en) * 2020-06-09 2022-12-21 南韓商阿特根公司 Pharmaceutical composition for subcutaneous injection comprising human hyaluronidase ph20 variant and drug
CN112143810B (en) * 2020-09-29 2023-11-21 南方医科大学中西医结合医院 Gene markers for predicting cancer immunotherapy effect and application thereof
WO2022135402A1 (en) * 2020-12-24 2022-06-30 信达生物制药(苏州)有限公司 Use of pd-l1 and/or mhc-2 biomarker in prediction of therapeutic efficacy in lung cancer patients
KR102371762B1 (en) * 2020-12-29 2022-03-07 중앙대학교 산학협력단 Use for regulating cell differentiation and apoptosis by BRCA1 mediated NSD2 ubiquitination
CN113005146A (en) * 2021-03-10 2021-06-22 香港理工大学深圳研究院 Recombinant plasmid, construction method thereof, recombinant image system and application
WO2022194255A1 (en) * 2021-03-19 2022-09-22 Shanghai Junshi Biosciences Co., Ltd. Method of treating urothelial carcinoma
WO2022245692A1 (en) * 2021-05-19 2022-11-24 Merck Sharp & Dohme Llc Treatment of cancer patients with setd2 biomarker alteration with a pd-1 antagonist
WO2023049859A1 (en) * 2021-09-24 2023-03-30 The Regents Of The University Of California Methods to predict the efficacy of neoadjuvant anti-pd-1 therapy in resectable oral-cavity squamous cell carcinoma and target post-surgical relapses
CN113981080A (en) * 2021-10-15 2022-01-28 复旦大学附属肿瘤医院 Method for generating and analyzing prediction index of platinum treatment sensitivity of advanced triple-negative breast cancer
WO2023086951A1 (en) * 2021-11-12 2023-05-19 Foundation Medicine, Inc. Circulating tumor dna fraction and uses thereof
CN114213542B (en) * 2021-12-24 2023-06-23 郑州大学第三附属医院(河南省妇幼保健院) CPS-I antibodies and uses thereof
WO2023209035A1 (en) * 2022-04-26 2023-11-02 F. Hoffmann-La Roche Ag Methods and systems for predicting cancer therapy response
CN114736967B (en) * 2022-05-07 2024-06-11 北京大学肿瘤医院 Markers and methods for predicting primary drug resistance of immune checkpoint inhibitor therapy
EP4310197A1 (en) 2022-07-21 2024-01-24 Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy
EP4361288A1 (en) * 2022-10-25 2024-05-01 Fundación Instituto de Investigación Sanitaria De Santiago de Compostela (FIDIS) Personalized immunotherapy in renal carcinoma
CN115449555B (en) * 2022-10-26 2023-10-13 山东大学 Application of ADGRA2 as biomarker for breast cancer chemotherapy efficacy and prognosis evaluation
CN115825441B (en) * 2023-01-30 2023-05-26 上海秤信生物科技有限公司 Autoantibody marker for predicting immune neoadjuvant therapeutic effect of patients with lung cancer in third stage

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US6362325B1 (en) 1988-11-07 2002-03-26 Advanced Research And Technology Institute, Inc. Murine 4-1BB gene
US6355476B1 (en) 1988-11-07 2002-03-12 Advanced Research And Technologyinc Nucleic acid encoding MIP-1α Lymphokine
ATE255131T1 (en) 1991-06-14 2003-12-15 Genentech Inc HUMANIZED HEREGULIN ANTIBODIES
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
IL129138A0 (en) 1996-10-11 2000-02-17 Bristol Myers Squibb Co Methods and compositions for immunomodulation
CZ303703B6 (en) 1998-12-23 2013-03-20 Pfizer Inc. Monoclonal antibody or fragment-binding antigen thereof, pharmaceutical composition in which the antibody or fragment is comprised, a cell line producing the antibody or fragment, process for preparing the antibody, isolated nucleic acid encoding hea
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
EP2283867B1 (en) 1999-06-25 2014-05-21 ImmunoGen, Inc. Methods of treatment using anti-ERBB antibody-maytansinoid conjugates
WO2001014557A1 (en) 1999-08-23 2001-03-01 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
EP1792991A1 (en) 1999-08-24 2007-06-06 Medarex, Inc. Human CTLA-4 antibodies and their uses
AU2001233027A1 (en) 2000-01-27 2001-08-07 Genetics Institute, Llc Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
EP1539237A4 (en) 2002-07-30 2006-05-24 Bristol Myers Squibb Co Humanized antibodies against human 4-1bb
EP1576014B1 (en) 2002-12-23 2011-06-29 Wyeth LLC Antibodies against pd-1 and uses thereof
CA2517145C (en) 2003-03-05 2017-08-01 Halozyme, Inc. Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
MXPA05013923A (en) 2003-07-02 2006-08-11 Univ Genova Compositions and methods for regulating nk cell activity.
PT1648507T (en) 2003-07-24 2017-03-20 Innate Pharma Sa Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
AU2005259221B2 (en) 2004-07-01 2011-02-10 Innate Pharma Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use
ATE531733T1 (en) 2005-01-06 2011-11-15 Novo Nordisk As KIR-BINDING ACTIVE INGREDIENTS AND METHODS FOR THEIR USE
US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
US7812135B2 (en) 2005-03-25 2010-10-12 Tolerrx, Inc. GITR-binding antibodies
KR101339628B1 (en) 2005-05-09 2013-12-09 메다렉스, 인코포레이티드 Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
KR101888321B1 (en) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. Human monoclonal antibodies to programmed death ligand 1(pd-l1)
EP2322557B1 (en) 2005-10-14 2017-08-30 Innate Pharma Compositions and methods for treating proliferative disorders
CA2647282A1 (en) 2006-04-05 2007-10-11 Pfizer Products Inc. Ctla4 antibody combination therapy
JP5478261B2 (en) 2007-01-11 2014-04-23 ノヴォ ノルディスク アクティーゼルスカブ Anti-KIR antibodies, formulations and uses thereof
JP2008278814A (en) 2007-05-11 2008-11-20 Igaku Seibutsugaku Kenkyusho:Kk Release of immunoregulation by agonistic anti-human gitr antibody, and application thereof
PL2170959T3 (en) 2007-06-18 2014-03-31 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
CA2693677C (en) 2007-07-12 2018-02-13 Tolerx, Inc. Combination therapies employing gitr binding molecules
WO2009045957A1 (en) 2007-10-01 2009-04-09 Medarex, Inc. Human antibodies that bind mesothelin, and uses thereof
CA2706926A1 (en) 2007-11-30 2009-06-11 Bristol-Myers Squibb Company Anti-b7h4 monoclonal antibody-drug conjugate and methods of use
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme Pd-1 binding proteins
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
WO2010065939A1 (en) 2008-12-05 2010-06-10 Indiana University Research & Technology Corporation Combination therapy to enhace nk cell mediated cytotoxicty
KR20210060670A (en) 2008-12-09 2021-05-26 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function
CA3067609A1 (en) 2009-09-03 2011-03-10 Merck Sharp & Dohme Corp. Anti-gitr antibodies
WO2011066389A1 (en) 2009-11-24 2011-06-03 Medimmmune, Limited Targeted binding agents against b7-h1
KR101958753B1 (en) 2010-04-13 2019-03-15 셀덱스 쎄라퓨틱스, 인크. Antibodies that bind human cd27 and uses thereof
TWI664191B (en) 2010-11-22 2019-07-01 天賜製藥公司 Nk cell modulating treatments and methods for treatment of hematological malignancies
CA2828940C (en) 2011-03-10 2024-04-16 Provectus Pharmaceuticals, Inc. Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer
WO2012145493A1 (en) 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
CN103717619B (en) 2011-05-25 2018-11-13 因内特制药股份有限公司 Treat the anti-KIR antibodies of inflammation and autoimmune disease
WO2013039954A1 (en) 2011-09-14 2013-03-21 Sanofi Anti-gitr antibodies
BR112014007487A2 (en) 2011-09-30 2017-04-04 Dana Farber Cancer Inst Inc therapeutic peptides
HUE043001T2 (en) 2011-11-09 2019-07-29 Bristol Myers Squibb Co Treatment of hematologic malignancies with an anti-cxcr4 antibody
CA2856895C (en) 2011-11-28 2021-10-26 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
CN104470949A (en) 2012-05-15 2015-03-25 百时美施贵宝公司 Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
AU2013267161A1 (en) 2012-05-31 2014-11-20 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
KR101549637B1 (en) 2012-06-08 2015-09-03 국립암센터 Novel epitope for switching to Th1 cell and use thereof
AR091649A1 (en) 2012-07-02 2015-02-18 Bristol Myers Squibb Co OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
NZ631405A (en) 2012-10-02 2017-01-27 Bristol Myers Squibb Co Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
AU2014228502A1 (en) 2013-03-15 2015-08-20 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
WO2014151006A2 (en) 2013-03-15 2014-09-25 Genentech, Inc. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
EP3770176A1 (en) 2013-05-02 2021-01-27 AnaptysBio, Inc. Antibodies directed against programmed death-1 (pd-1)
CA3175360C (en) 2013-05-31 2024-05-28 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-1
CN104250302B (en) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 The anti-antibody of PD 1 and its application
AR097306A1 (en) 2013-08-20 2016-03-02 Merck Sharp & Dohme MODULATION OF TUMOR IMMUNITY
TW201605896A (en) 2013-08-30 2016-02-16 安美基股份有限公司 GITR antigen binding proteins
PT3702373T (en) 2013-09-13 2022-09-27 Beigene Switzerland Gmbh Anti-pd1 antibodies and their use as therapeutics and diagnostics
EP3178849B1 (en) 2013-09-20 2019-03-20 Bristol-Myers Squibb Company Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
CA2932767A1 (en) 2013-12-06 2015-06-11 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
JP6502959B2 (en) 2013-12-12 2019-04-17 上海恒瑞医薬有限公司 PD-1 antibodies, antigen binding fragments thereof and their medical use
PE20161344A1 (en) * 2014-01-02 2016-12-23 Memorial Sloan Kettering Cancer Center DETERMINANTS OF CANCER RESPONSE TO IMMUNOTHERAPY
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
EP3498295A1 (en) 2014-05-28 2019-06-19 Agenus Inc. Anti-gitr antibodies and methods of use thereof
CN106999582A (en) * 2014-11-13 2017-08-01 约翰·霍普金斯大学 Checkpoint is blocked and microsatellite instability
MA40737A (en) * 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center DETERMINANTS OF CANCER RESPONSE TO PD-1 BLOCKED IMMUNOTHERAPY
CA2971734A1 (en) 2014-12-22 2016-06-30 Enumeral Biomedical Holdings, Inc. Anti-pd-1 antibodies
SG11201707383PA (en) 2015-03-13 2017-10-30 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
KR20170140316A (en) * 2015-04-28 2017-12-20 브리스톨-마이어스 스큅 컴퍼니 Treatment of PD-L1-positive melanoma with anti-PD-1 antibody
MA53355A (en) 2015-05-29 2022-03-16 Agenus Inc ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
WO2016197367A1 (en) 2015-06-11 2016-12-15 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
IL297090A (en) 2015-07-30 2022-12-01 Macrogenics Inc Pd-1-binding molecules and methods of use thereof
WO2017020291A1 (en) 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
WO2017024515A1 (en) 2015-08-11 2017-02-16 Wuxi Biologics (Cayman) Inc. Novel anti-pd-1 antibodies
MA42626A (en) 2015-08-11 2018-06-20 Open Monoclonal Tech Inc NEW ANTI-PD-1 ANTIBODIES
AR105654A1 (en) 2015-08-24 2017-10-25 Lilly Co Eli ANTIBODIES PD-L1 (LINKING 1 OF PROGRAMMED CELL DEATH)
PE20181322A1 (en) 2015-09-01 2018-08-14 Agenus Inc ANTI-PD1 ANTIBODY AND ITS METHODS OF USE
TW202208440A (en) 2015-12-14 2022-03-01 美商宏觀基因股份有限公司 Bispecific Molecules Having Immunoreactivity with PD-1 and CTLA-4, and Methods of Use Thereof
EP3402512A4 (en) 2016-01-11 2019-09-25 Armo Biosciences, Inc. Interleukin-10 in production of antigen-specific cd8+ t cells and methods of use of same
WO2017132827A1 (en) 2016-02-02 2017-08-10 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
CN108029076B (en) 2016-02-02 2020-03-10 华为技术有限公司 Method for determining transmission power, user equipment and base station
SG10201911972QA (en) 2016-07-14 2020-02-27 Bristol Myers Squibb Co Antibodies against tim3 and uses thereof
CN110418851A (en) * 2016-10-06 2019-11-05 基因泰克公司 The treatment of cancer and diagnostic method
WO2019075468A1 (en) * 2017-10-15 2019-04-18 Bristol-Myers Squibb Company Methods of treating tumor

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