MX2019009839A - Celulas eritroides funcionalizadas. - Google Patents
Celulas eritroides funcionalizadas.Info
- Publication number
- MX2019009839A MX2019009839A MX2019009839A MX2019009839A MX2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A
- Authority
- MX
- Mexico
- Prior art keywords
- erythroid cells
- functionalized
- functionalized erythroid
- reagents
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Abstract
En el presente documento se describen nuevas preparaciones de células eritroides funcionalizadas y composiciones, reactivos y métodos relacionados para su uso en aplicaciones farmacéuticas y veterinarias.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762460589P | 2017-02-17 | 2017-02-17 | |
US201762542142P | 2017-08-07 | 2017-08-07 | |
PCT/US2018/000042 WO2018151829A1 (en) | 2017-02-17 | 2018-02-16 | Functionalized erythroid cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019009839A true MX2019009839A (es) | 2019-10-22 |
Family
ID=61873874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009839A MX2019009839A (es) | 2017-02-17 | 2018-02-16 | Celulas eritroides funcionalizadas. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11020435B2 (es) |
EP (1) | EP3583202A1 (es) |
JP (1) | JP2020507329A (es) |
KR (1) | KR20190117667A (es) |
CN (1) | CN110520522A (es) |
AU (1) | AU2018221227A1 (es) |
BR (1) | BR112019016951A2 (es) |
CA (1) | CA3052142A1 (es) |
IL (1) | IL268359A (es) |
MX (1) | MX2019009839A (es) |
SG (1) | SG11201906933SA (es) |
WO (1) | WO2018151829A1 (es) |
Families Citing this family (54)
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CA2930665A1 (en) | 2013-11-18 | 2015-05-21 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
CA2944492A1 (en) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
SG11201805253SA (en) | 2016-01-11 | 2018-07-30 | Rubius Therapeutics Inc | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
EP3583202A1 (en) * | 2017-02-17 | 2019-12-25 | Rubius Therapeutics, Inc. | Functionalized erythroid cells |
US20190160102A1 (en) | 2017-11-03 | 2019-05-30 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
US20190290686A1 (en) * | 2017-12-23 | 2019-09-26 | Rubius Therapeutics, Inc. | Artificial antigen presenting cells and methods of use |
US20190330591A1 (en) | 2018-01-10 | 2019-10-31 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
AU2019232012A1 (en) | 2018-03-08 | 2020-09-24 | Rubius Therapeutics, Inc. | Therapeutic cell systems and methods for treating cancer and infectious diseases |
US11166996B2 (en) | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
US20220112489A1 (en) | 2019-01-18 | 2022-04-14 | Flagship Pioneering, Inc. | Trem compositions and uses thereof |
WO2020172472A1 (en) | 2019-02-20 | 2020-08-27 | Rubius Therapeutics, Inc. | Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use |
KR20210135265A (ko) | 2019-03-04 | 2021-11-12 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 원형 폴리리보뉴클레오티드 및 그의 약제학적 조성물 |
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CN114269921A (zh) | 2019-05-31 | 2022-04-01 | 旗舰创业股份有限公司 | TREM组合物用以调节tRNA池的用途 |
WO2020252436A1 (en) | 2019-06-14 | 2020-12-17 | Flagship Pioneering Innovations Vi, Llc | Circular rnas for cellular therapy |
US20220305128A1 (en) | 2019-06-19 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
US20220364075A1 (en) | 2019-11-04 | 2022-11-17 | Flagship Pioneering, Inc. | Methods of modifying a nucleic acid sequence |
AU2020379762A1 (en) | 2019-11-04 | 2022-05-26 | Flagship Pioneering, Inc. | TREM compositions for con-rare codons and related uses |
WO2021155177A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising linear polyribonucleotides for protein modulation and uses thereof |
EP4096681A1 (en) | 2020-01-29 | 2022-12-07 | Flagship Pioneering Innovations VI, LLC | Delivery of compositions comprising circular polyribonucleotides |
TW202142689A (zh) | 2020-01-29 | 2021-11-16 | 美商旗艦先鋒創新有限責任公司 | 用於轉譯之組合物及其使用方法 |
EP4103696A1 (en) | 2020-02-10 | 2022-12-21 | Rubius Therapeutics, Inc. | Engineered erythroid cells including hla-g polypeptides and methods of use thereof |
WO2021185359A1 (en) * | 2020-03-20 | 2021-09-23 | Westlake Therapeutics (Hangzhou) Co. Limited | Modified red blood cells and uses thereof for delivering agents |
EP4153152A1 (en) | 2020-05-20 | 2023-03-29 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing human polyclonal antibodies |
JP2023526423A (ja) | 2020-05-20 | 2023-06-21 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | 免疫原性組成物及びその使用 |
CA3179420A1 (en) | 2020-05-20 | 2021-11-25 | Avak Kahvejian | Coronavirus antigen compositions and their uses |
JP2023527413A (ja) | 2020-05-29 | 2023-06-28 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | Trem組成物及びそれに関連する方法 |
WO2021243301A2 (en) | 2020-05-29 | 2021-12-02 | Flagship Pioneering Innovations Vi, Llc. | Trem compositions and methods relating thereto |
US20230233514A1 (en) | 2020-06-23 | 2023-07-27 | Flagship Pioneering, Inc. | Antiviral compounds and methods of using the same |
WO2022051629A1 (en) | 2020-09-03 | 2022-03-10 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
JP2024501288A (ja) | 2020-12-23 | 2024-01-11 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | 修飾tremの組成物及びその使用 |
US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
WO2023284742A1 (en) * | 2021-07-13 | 2023-01-19 | Westlake Therapeutics (Hangzhou) Co. Limited | Cells modified by conjugated n-terminal glycine and uses thereof |
EP4377457A1 (en) | 2021-07-26 | 2024-06-05 | Flagship Pioneering Innovations VI, LLC | Trem compositions and uses thereof |
TW202330916A (zh) | 2021-09-17 | 2023-08-01 | 美商旗艦先鋒創新有限責任公司 | 用於產生環狀多核糖核苷酸之組成物和方法 |
AU2022370530A1 (en) | 2021-10-18 | 2024-05-02 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
AU2022397292A1 (en) | 2021-11-24 | 2024-05-30 | Flagship Pioneering Innovations Vi, Llc | Varicella-zoster virus immunogen compositions and their uses |
CA3238735A1 (en) | 2021-11-24 | 2023-06-01 | Jennifer A. Nelson | Immunogenic compositions and their uses |
CA3239266A1 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovations Vi, Llc | Coronavirus immunogen compositions and their uses |
WO2023122745A1 (en) | 2021-12-22 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
WO2023122789A1 (en) | 2021-12-23 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
WO2023196593A1 (en) * | 2022-04-08 | 2023-10-12 | The University Of North Carolina At Chapel Hill | Antigen-independent targeted delivery of therapeutic agents |
WO2023220083A1 (en) | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods of use for treating proliferative disorders |
WO2023220729A2 (en) | 2022-05-13 | 2023-11-16 | Flagship Pioneering Innovations Vii, Llc | Double stranded dna compositions and related methods |
WO2023230570A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating genetic drivers |
WO2023230573A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulation of immune responses |
WO2023230578A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating circulating factors |
WO2023230549A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulation of tumor suppressors and oncogenes |
WO2023230566A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating cytokines |
WO2023250112A1 (en) | 2022-06-22 | 2023-12-28 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
WO2024097664A1 (en) | 2022-10-31 | 2024-05-10 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
WO2024102799A1 (en) | 2022-11-08 | 2024-05-16 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
WO2024129988A1 (en) | 2022-12-14 | 2024-06-20 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for delivery of therapeutic agents to bone |
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US20100040546A1 (en) | 2008-08-13 | 2010-02-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Biological targeting compositions and methods of using the same |
AU2010215936B2 (en) | 2009-02-21 | 2015-03-05 | Covidien Lp | Medical devices having activated surfaces |
WO2011059586A2 (en) | 2009-10-30 | 2011-05-19 | The Regents Of The University Of Michigan | Multifunctional small molecules |
CA2758390A1 (en) * | 2011-11-14 | 2013-05-14 | Ibc Pharmaceuticals, Inc. | Stem cell targeting with dock-and-lock (dnl) complexes |
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CA2930665A1 (en) | 2013-11-18 | 2015-05-21 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
CA2944492A1 (en) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
US10053683B2 (en) | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
US20180110831A1 (en) | 2015-03-09 | 2018-04-26 | Stc.Unm | Cd 47 containing porous nanoparticle supported lipid bilayers (protocells) field of the invention |
WO2016183482A1 (en) | 2015-05-13 | 2016-11-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
SG11201805253SA (en) * | 2016-01-11 | 2018-07-30 | Rubius Therapeutics Inc | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
WO2017152077A1 (en) | 2016-03-04 | 2017-09-08 | Whitehead Institute For Biomedical Research | Efficient generation of human red blood cells via enriching peripheral blood erythroid progenitors |
US20190161730A1 (en) | 2016-07-07 | 2019-05-30 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems expressing exogenous rna |
US20180153989A1 (en) * | 2016-12-02 | 2018-06-07 | Rubius Therapeutics, Inc. | Compositions and methods related to cell systems for penetrating solid tumors |
EP3583202A1 (en) * | 2017-02-17 | 2019-12-25 | Rubius Therapeutics, Inc. | Functionalized erythroid cells |
US20190062788A1 (en) * | 2017-08-22 | 2019-02-28 | Rubius Therapeutics, Inc. | Lipid nanoparticle methods and compositions for producing engineered erythroid cells |
US20190160102A1 (en) | 2017-11-03 | 2019-05-30 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
WO2019133881A1 (en) | 2017-12-29 | 2019-07-04 | Rubius Therapeutics, Inc. | Gene editing and targeted transcriptional modulation for enginerering erythroid cells |
US20190330591A1 (en) | 2018-01-10 | 2019-10-31 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
CN113366102A (zh) * | 2018-12-03 | 2021-09-07 | 鲁比厄斯治疗法股份有限公司 | 包含hla-e和hla-g分子的人工抗原呈递细胞和使用方法 |
WO2020172472A1 (en) * | 2019-02-20 | 2020-08-27 | Rubius Therapeutics, Inc. | Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use |
CN114007627A (zh) * | 2019-04-26 | 2022-02-01 | 鲁比厄斯治疗法股份有限公司 | 包含去核类红细胞的缓冲组合物 |
CN114127252A (zh) * | 2019-05-24 | 2022-03-01 | 鲁比厄斯治疗法股份有限公司 | 生成去核红系细胞的方法 |
EP4103696A1 (en) * | 2020-02-10 | 2022-12-21 | Rubius Therapeutics, Inc. | Engineered erythroid cells including hla-g polypeptides and methods of use thereof |
-
2018
- 2018-02-16 EP EP18715274.9A patent/EP3583202A1/en not_active Withdrawn
- 2018-02-16 AU AU2018221227A patent/AU2018221227A1/en not_active Withdrawn
- 2018-02-16 MX MX2019009839A patent/MX2019009839A/es unknown
- 2018-02-16 US US15/932,341 patent/US11020435B2/en active Active
- 2018-02-16 WO PCT/US2018/000042 patent/WO2018151829A1/en unknown
- 2018-02-16 CA CA3052142A patent/CA3052142A1/en active Pending
- 2018-02-16 KR KR1020197027048A patent/KR20190117667A/ko active Search and Examination
- 2018-02-16 JP JP2019544032A patent/JP2020507329A/ja not_active Ceased
- 2018-02-16 BR BR112019016951-2A patent/BR112019016951A2/pt not_active IP Right Cessation
- 2018-02-16 SG SG11201906933SA patent/SG11201906933SA/en unknown
- 2018-02-16 CN CN201880011595.7A patent/CN110520522A/zh active Pending
-
2019
- 2019-07-30 IL IL268359A patent/IL268359A/en unknown
-
2021
- 2021-05-27 US US17/331,884 patent/US20210290682A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112019016951A2 (pt) | 2020-05-26 |
SG11201906933SA (en) | 2019-09-27 |
EP3583202A1 (en) | 2019-12-25 |
US11020435B2 (en) | 2021-06-01 |
KR20190117667A (ko) | 2019-10-16 |
WO2018151829A1 (en) | 2018-08-23 |
CA3052142A1 (en) | 2018-08-23 |
AU2018221227A1 (en) | 2019-08-15 |
JP2020507329A (ja) | 2020-03-12 |
US20210290682A1 (en) | 2021-09-23 |
US20180344770A1 (en) | 2018-12-06 |
RU2019129088A3 (es) | 2021-03-25 |
IL268359A (en) | 2019-09-26 |
CN110520522A (zh) | 2019-11-29 |
RU2019129088A (ru) | 2021-03-17 |
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