MX2019008195A - Celulas madre mesenquimales primarias inmunoprotectoras y metodos. - Google Patents

Celulas madre mesenquimales primarias inmunoprotectoras y metodos.

Info

Publication number
MX2019008195A
MX2019008195A MX2019008195A MX2019008195A MX2019008195A MX 2019008195 A MX2019008195 A MX 2019008195A MX 2019008195 A MX2019008195 A MX 2019008195A MX 2019008195 A MX2019008195 A MX 2019008195A MX 2019008195 A MX2019008195 A MX 2019008195A
Authority
MX
Mexico
Prior art keywords
methods
stem cells
mesenchymal stem
primary mesenchymal
polypeptides
Prior art date
Application number
MX2019008195A
Other languages
English (en)
Inventor
F Garry Robert
B Wilson Russell
M Branco Luis
A Bunnell Bruce
E Hopkins Samuel
Original Assignee
The Administrators Of The Tulane Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Administrators Of The Tulane Educational Fund filed Critical The Administrators Of The Tulane Educational Fund
Publication of MX2019008195A publication Critical patent/MX2019008195A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)

Abstract

Se describen en la presente células madre mesenquimales primarias inmunoprotectoras (IP-MSC) que expresan episomalmente polipétidos inmunoreactivos múltiples que dirigen específicamente un patógeno (por ejemplo, una especie infecciosa de virus, bacteria, o parásito) o toxina. La IP-MSC expresa dos o más (por ejemplo, 2 hasta alrededor de 100) polipéptidos inmunoreactivos (por ejemplo, anticuerpos completos, anticuerpos de cadena sencilla (ScFV), fragmentos de anticuerpo Fab o F(ab)2, diacuerpos, tricuerpos, y similares), y opcionalmente uno o más de otros polipéptidos inmunomoduladores, por ejemplo, una citoquina tal como una interleucina (por ejemplo, IL-2, IL-4, IL-6, IL-7, IL-9, e IL-12), un interferón (por ejemplo, IFNa, IFNß, o IFN?), y similares, que pueden aumentar la efectividad de los polipéptidos inmunoreactivos.
MX2019008195A 2013-03-14 2015-09-14 Celulas madre mesenquimales primarias inmunoprotectoras y metodos. MX2019008195A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/826,285 US9101597B2 (en) 2013-03-14 2013-03-14 Immunoprotective primary mesenchymal stem cells and methods

Publications (1)

Publication Number Publication Date
MX2019008195A true MX2019008195A (es) 2019-09-11

Family

ID=51527936

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2015013387A MX366419B (es) 2013-03-14 2014-03-13 Celulas madre mesenquimales primarias inmunoprotectoras y metodos.
MX2019000704A MX2019000704A (es) 2013-03-14 2014-03-13 Celulas madre mesenquimales primarias inmunoprotectoras y metodos.
MX2019008195A MX2019008195A (es) 2013-03-14 2015-09-14 Celulas madre mesenquimales primarias inmunoprotectoras y metodos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2015013387A MX366419B (es) 2013-03-14 2014-03-13 Celulas madre mesenquimales primarias inmunoprotectoras y metodos.
MX2019000704A MX2019000704A (es) 2013-03-14 2014-03-13 Celulas madre mesenquimales primarias inmunoprotectoras y metodos.

Country Status (13)

Country Link
US (4) US9101597B2 (es)
EP (1) EP2968611B1 (es)
JP (1) JP6566932B2 (es)
CN (1) CN105188768B (es)
AR (1) AR095368A1 (es)
AU (1) AU2014244057B2 (es)
CA (1) CA2906592C (es)
EA (1) EA201591673A1 (es)
ES (1) ES2881383T3 (es)
HK (1) HK1219050A1 (es)
MX (3) MX366419B (es)
TW (2) TWI689590B (es)
WO (1) WO2014160157A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101597B2 (en) * 2013-03-14 2015-08-11 The Administration Of The Tulane Educational Fund Immunoprotective primary mesenchymal stem cells and methods
US11357866B2 (en) * 2013-04-03 2022-06-14 The Administrators Of The Tulane Educational Fund Expression of HIV inhibitors by mesenchymal stem cells
EP3656387A3 (en) 2014-08-18 2020-07-01 Apceth GmbH & Co. KG Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells
US10654943B2 (en) 2015-06-02 2020-05-19 The Rockefeller University Tri-specific antibodies for HIV therapy
JP2019509264A (ja) 2016-02-04 2019-04-04 ロングエバーオン エルエルシーＬｏｎｇｅｖｅｒｏｎ Ｌｌｃ ワクチンアジュバントとしての間葉系幹細胞及びそれを使用するための方法
EP3462883B1 (en) * 2016-06-07 2023-08-16 The Pacific Heart, Lung,&Blood Institute Compositions and their use in treating cancer
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CN111363045B (zh) * 2020-02-18 2021-12-17 厦门大学 一种流感、hiv嵌合蛋白及嵌合病毒疫苗的制备方法
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KR20230146008A (ko) 2020-12-31 2023-10-18 크리스퍼 테라퓨틱스 아게 범용 공여자 세포

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EP1015024A1 (en) * 1997-09-20 2000-07-05 Osiris Therapeutics, Inc. Antigen presenting mesenchymal stem cells
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US20070196365A1 (en) * 2001-02-20 2007-08-23 Dov Zipori Immunoglobulin heavy chain variants expressed in mesenchymal cells and therapeutic uses thereof
EP1456358A2 (en) * 2001-09-20 2004-09-15 Centre for Translational Research in Cancer Cultured stromal cells and uses thereof
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Also Published As

Publication number Publication date
AR095368A1 (es) 2015-10-14
US20160129110A1 (en) 2016-05-12
ES2881383T3 (es) 2021-11-29
MX2015013387A (es) 2016-08-11
CN105188768A (zh) 2015-12-23
TW201907005A (zh) 2019-02-16
JP6566932B2 (ja) 2019-08-28
EP2968611A4 (en) 2016-08-17
TWI689590B (zh) 2020-04-01
US20190282694A1 (en) 2019-09-19
US20140271580A1 (en) 2014-09-18
TW201514301A (zh) 2015-04-16
MX366419B (es) 2019-07-08
CN105188768B (zh) 2019-06-28
US11123427B2 (en) 2021-09-21
EP2968611A1 (en) 2016-01-20
AU2014244057A1 (en) 2015-10-29
US9101597B2 (en) 2015-08-11
HK1219050A1 (zh) 2017-03-24
MX2019000704A (es) 2020-11-12
TWI650420B (zh) 2019-02-11
CA2906592C (en) 2022-01-18
EA201591673A1 (ru) 2016-01-29
US10357562B2 (en) 2019-07-23
AU2014244057B2 (en) 2018-12-06
WO2014160157A1 (en) 2014-10-02
US20210401984A1 (en) 2021-12-30
JP2016518819A (ja) 2016-06-30
EP2968611B1 (en) 2021-05-05
CA2906592A1 (en) 2014-10-02

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