MX2019006244A - Construcciones de vectores virales para la expresion de adyuvantes geneticos que activan la ruta sting. - Google Patents

Construcciones de vectores virales para la expresion de adyuvantes geneticos que activan la ruta sting.

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Publication number
MX2019006244A
MX2019006244A MX2019006244A MX2019006244A MX2019006244A MX 2019006244 A MX2019006244 A MX 2019006244A MX 2019006244 A MX2019006244 A MX 2019006244A MX 2019006244 A MX2019006244 A MX 2019006244A MX 2019006244 A MX2019006244 A MX 2019006244A
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MX
Mexico
Prior art keywords
vectors
activating
expression
sting pathway
adjuvant
Prior art date
Application number
MX2019006244A
Other languages
English (en)
Inventor
Cecile Bauche
Frederic Mourlane
Renaud Vaillant
Emeline Sarry
Original Assignee
Aratinga Bio Aio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aratinga Bio Aio filed Critical Aratinga Bio Aio
Publication of MX2019006244A publication Critical patent/MX2019006244A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/04—Antibacterial agents
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    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C12N2710/16011—Herpesviridae
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Abstract

Los vectores virales se proporcionan para su uso como agentes imunoterapeuticos genéticos, que incluyen vacunas preventivas y terapéuticas, así como composiciones para mejorar las respuestas inmunitarias celulares. Los vectores son particularmente útiles para trtar o prevenir el cáncer y las enfermedades infecciosas. Los vectores incluyen vectores lentivirales que codifican uno o más antígenos y un adyuvante, y opcionalmente pueden codificar uno o mas moléculas inhibidoras de punto de control solubles. El coadyuvante es una proteína de fusión que incluye la proteína membrana latente 1 (LMP1) del virus de Epstein Barr con la cual el dominio intracitoplasmatico ha sido reemplazado por el IPS1 humano o una variante del mimo capaz de activar la ruta STING. Las secuencias codificadas por vector son condones optimizados para la expresión humana.
MX2019006244A 2016-11-28 2017-11-28 Construcciones de vectores virales para la expresion de adyuvantes geneticos que activan la ruta sting. MX2019006244A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662426855P 2016-11-28 2016-11-28
PCT/IB2017/001540 WO2018096395A1 (en) 2016-11-28 2017-11-28 Viral vector constructs for expression of genetic adjuvants activating the sting pathway

Publications (1)

Publication Number Publication Date
MX2019006244A true MX2019006244A (es) 2020-10-20

Family

ID=60990827

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019006244A MX2019006244A (es) 2016-11-28 2017-11-28 Construcciones de vectores virales para la expresion de adyuvantes geneticos que activan la ruta sting.

Country Status (10)

Country Link
US (1) US11638752B2 (es)
EP (1) EP3545097A1 (es)
JP (2) JP2020500553A (es)
KR (1) KR20190123257A (es)
CN (1) CN110225976A (es)
AU (1) AU2017363964A1 (es)
BR (1) BR112019010933A2 (es)
CA (1) CA3083881A1 (es)
MX (1) MX2019006244A (es)
WO (1) WO2018096395A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022270946A1 (ko) * 2021-06-23 2022-12-29 한국생명공학연구원 세포내 면역 반응의 억제를 통한 목적 단백질의 발현 향상용 재조합 벡터 및 이의 응용

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011119628A2 (en) * 2010-03-23 2011-09-29 The Regents Of The University Of California Compositions and methods for self-adjuvanting vaccines against microbes and tumors
US10093701B2 (en) 2012-09-07 2018-10-09 University Of Miami Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof
TWI733719B (zh) * 2015-12-07 2021-07-21 美商河谷控股Ｉｐ有限責任公司 改善的組合物及用於新表位之病毒遞送的方法及其應用

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Publication number Publication date
US20190328872A1 (en) 2019-10-31
KR20190123257A (ko) 2019-10-31
AU2017363964A1 (en) 2019-07-18
EP3545097A1 (en) 2019-10-02
WO2018096395A1 (en) 2018-05-31
JP2020500553A (ja) 2020-01-16
JP2023002717A (ja) 2023-01-10
US11638752B2 (en) 2023-05-02
CN110225976A (zh) 2019-09-10
CA3083881A1 (en) 2018-05-31
BR112019010933A2 (pt) 2019-10-01

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