MX2019001167A - Derivados sinteticos estables de poliribosilribitolfosfato resistentes a la hidrolisis como vacunas contra haemophilus influenzae tipo b. - Google Patents

Derivados sinteticos estables de poliribosilribitolfosfato resistentes a la hidrolisis como vacunas contra haemophilus influenzae tipo b.

Info

Publication number
MX2019001167A
MX2019001167A MX2019001167A MX2019001167A MX2019001167A MX 2019001167 A MX2019001167 A MX 2019001167A MX 2019001167 A MX2019001167 A MX 2019001167A MX 2019001167 A MX2019001167 A MX 2019001167A MX 2019001167 A MX2019001167 A MX 2019001167A
Authority
MX
Mexico
Prior art keywords
formula
haemophilus influenzae
polyribosylribitolphosphate
derivatives
influenzae type
Prior art date
Application number
MX2019001167A
Other languages
English (en)
Inventor
H Seeberger Peter
Lebev Pereira Claney
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of MX2019001167A publication Critical patent/MX2019001167A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención proporciona un sacárido sintético estable de un derivado de poliribosilribitol-fosfato (PRP) de Hib y el conjugado del mismo. Dicho sacárido, dicho conjugado y composiciones farmacéuticas del mismo son resistentes a la hidrólisis, son estables a largo plazo y son útiles para la prevención y/o el tratamiento de enfermedades asociadas con Haemophilus influenzae, y más específicamente de enfermedades asociadas con Haemophilus influenzae tipo b, las enfermedades seleccionadas preferiblemente de meningitis, neumonía y epiglotitis.
MX2019001167A 2016-07-28 2017-07-28 Derivados sinteticos estables de poliribosilribitolfosfato resistentes a la hidrolisis como vacunas contra haemophilus influenzae tipo b. MX2019001167A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16181659 2016-07-28
EPPCT/EP2017/062725 2017-05-26
PCT/EP2017/069254 WO2018020046A1 (en) 2016-07-28 2017-07-28 Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against haemophilus influenzae type b

Publications (1)

Publication Number Publication Date
MX2019001167A true MX2019001167A (es) 2019-09-16

Family

ID=59384191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019001167A MX2019001167A (es) 2016-07-28 2017-07-28 Derivados sinteticos estables de poliribosilribitolfosfato resistentes a la hidrolisis como vacunas contra haemophilus influenzae tipo b.

Country Status (12)

Country Link
US (1) US11014952B2 (es)
EP (1) EP3491000A1 (es)
JP (1) JP6784841B2 (es)
KR (1) KR102549847B1 (es)
CN (1) CN109843899B (es)
AU (1) AU2017302136B2 (es)
BR (1) BR112019001486B1 (es)
CA (1) CA3030521A1 (es)
IL (1) IL264418A (es)
MX (1) MX2019001167A (es)
SG (1) SG11201811350QA (es)
WO (1) WO2018020046A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3890775A1 (en) 2018-12-06 2021-10-13 GlaxoSmithKline Biologicals S.A. Immunogenic compositions
EP3799884A1 (en) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogenic compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223009A (en) 1986-12-31 1990-06-26 Nl Rivm Of Thoven Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens
EP0320942A3 (en) 1987-12-18 1989-10-04 American Cyanamid Company Novel polysaccharides novel macromolecular conjugates of the polysaccharides
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
JP3330935B2 (ja) 1990-12-21 2002-10-07 アンテックス バイオロジックス，インコーポレーテッド ヘモフィルス・インフルエンザ用アドヘシン−オリゴ糖複合体ワクチン
CU22904A1 (es) 1999-08-30 2004-01-23 Univ De Ottawa Oligosacáridos derivados de ribosa- ribitol-fosfato, métodos para prepararlos, inmunógenos que los comprenden y vacunas que comprenden dichos inmunógenos
US9938312B2 (en) 2011-03-25 2018-04-10 University Of Georgia Research Foundation, Inc. Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
IN2013DE02989A (es) * 2013-10-08 2015-04-10 Msd Wellcome Trust Hilleman Lab Pvt Ltd
WO2016044164A1 (en) 2014-09-15 2016-03-24 Wayne State University Novel synthetic anticancer, antifungal, and antibacterial vaccines

Also Published As

Publication number Publication date
CN109843899A (zh) 2019-06-04
BR112019001486A2 (pt) 2019-04-30
US20190153015A1 (en) 2019-05-23
EP3491000A1 (en) 2019-06-05
CA3030521A1 (en) 2018-02-01
US11014952B2 (en) 2021-05-25
KR20190034571A (ko) 2019-04-02
SG11201811350QA (en) 2019-01-30
AU2017302136B2 (en) 2021-05-27
JP2019527243A (ja) 2019-09-26
BR112019001486B1 (pt) 2024-02-27
KR102549847B1 (ko) 2023-06-29
AU2017302136A1 (en) 2019-01-17
JP6784841B2 (ja) 2020-11-11
IL264418A (en) 2019-02-28
CN109843899B (zh) 2022-04-19
WO2018020046A1 (en) 2018-02-01

Similar Documents

Publication Publication Date Title
MX2019009861A (es) Composiciones farmaceuticas de un derivado de acido biliar y microbioma y usos de las mismas.
MX2018002402A (es) Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4).
MD3313851T2 (ro) Noi derivați hidroxiester, procedeu pentru prepararea lor și compoziții farmaceutice care îi conțin
WO2019126253A8 (en) Aryl and heteroaryl substituted indole compounds
MD3468974T2 (ro) Noi derivați de piperidinil, procedeu pentru prepararea lor și compoziții farmaceutice care ii conțin
MY192521A (en) Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
MD3468971T2 (ro) Noi derivați de piperidinil (hetero)aril-substituiţi, procedeu de obţinere a acestora și compoziții farmaceutice care îi conțin
NZ723151A (en) 2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom
MX2020007265A (es) Derivados de rapamicina.
TW201613880A (en) Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole
EA034243B9 (ru) Фармацевтические композиции, содержащие azd9291, для лечения рака
MX2016015565A (es) Ciertos inhibidores de la proteina quinasa.
PH12017501539A1 (en) Disacetoxytubulysin h and analogs thereof
TN2019000204A1 (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
BR112018007128A2 (pt) compostos para a inibição de câncer e epigênese
EA201691670A1 (ru) Тетразолонзамещенные дигидропиридиноновые ингибиторы mgat2
EA201300990A1 (ru) Парентеральное введение тапентадола
AU2024202522A1 (en) Crystalline forms of 3-substituted 1,2,4-oxadiazole
SG10201906942PA (en) Piperidine cxcr7 receptor modulators
MX2021002529A (es) Analogos de illudin, usos de los mismos y metodos para sintetizar los mismos.
PH12017501876A1 (en) Pyridopyrimidones and their use as nmda receptor modulators
TN2016000490A1 (en) Naphthyridinedione derivatives.
MX2019001167A (es) Derivados sinteticos estables de poliribosilribitolfosfato resistentes a la hidrolisis como vacunas contra haemophilus influenzae tipo b.
PH12016502568A1 (en) Novel heterocyclic compound
EA201790632A1 (ru) 4'-винилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк респираторно-синцитиального вируса