MX2018001315A - Inhibidores de fucosidasa. - Google Patents
Inhibidores de fucosidasa.Info
- Publication number
- MX2018001315A MX2018001315A MX2018001315A MX2018001315A MX2018001315A MX 2018001315 A MX2018001315 A MX 2018001315A MX 2018001315 A MX2018001315 A MX 2018001315A MX 2018001315 A MX2018001315 A MX 2018001315A MX 2018001315 A MX2018001315 A MX 2018001315A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- tumors
- fucosidase inhibitors
- fucosidase
- liver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Abstract
La presente invención se refiere, en general, a compuestos que son de utilidad como inhibidores de las enzimas fucosidasa y a métodos y composiciones para el tratamiento de tumores o cánceres, tales como trastornos hepáticos y tumores de hígado (por ejemplo, carcinoma hepatocelular), con un compuesto descrito en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562199194P | 2015-07-30 | 2015-07-30 | |
PCT/US2016/044607 WO2017019925A1 (en) | 2015-07-30 | 2016-07-29 | Fucosidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018001315A true MX2018001315A (es) | 2018-08-15 |
Family
ID=56616083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018001315A MX2018001315A (es) | 2015-07-30 | 2016-07-29 | Inhibidores de fucosidasa. |
Country Status (15)
Country | Link |
---|---|
US (2) | US9951013B2 (es) |
EP (1) | EP3328832B1 (es) |
JP (2) | JP6981961B2 (es) |
KR (1) | KR20180030699A (es) |
CN (1) | CN107848970B (es) |
AR (1) | AR105540A1 (es) |
AU (2) | AU2016298324A1 (es) |
BR (1) | BR112018000961A2 (es) |
CA (1) | CA2992033A1 (es) |
IL (1) | IL256662B (es) |
MX (1) | MX2018001315A (es) |
RU (1) | RU2765202C2 (es) |
TW (1) | TWI777923B (es) |
WO (1) | WO2017019925A1 (es) |
ZA (1) | ZA201800638B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
PL2344129T3 (pl) | 2008-10-07 | 2018-07-31 | Horizon Orphan Llc | Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych |
PT2346509T (pt) | 2008-10-07 | 2020-08-05 | Horizon Orphan Llc | Inalação de levofloxacina para redução da inflamação pulmonar |
AU2010289326B2 (en) | 2009-09-04 | 2015-09-24 | Horizon Therapeutics U.S. Holding Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
AR105540A1 (es) | 2015-07-30 | 2017-10-11 | Raptor Pharmaceuticals Inc | Inhibidores de fucosidasas |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US5186941A (en) | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
US5153325A (en) | 1989-06-27 | 1992-10-06 | Monsanto Company | Fucosidase inhibitor |
US5017704A (en) | 1989-06-27 | 1991-05-21 | Monsanto Company | Fucosidase inhibitor |
US5096909A (en) | 1989-06-27 | 1992-03-17 | Monsanto Company | Fucosidase inhibitor |
US5100797A (en) | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
US5240707A (en) | 1990-04-12 | 1993-08-31 | Merrell Dow Pharma | Alpha-mannosidase and fucosidase inhibitors |
WO1995020597A1 (en) * | 1994-01-26 | 1995-08-03 | Ciba-Geigy Ag | Modified oligonucleotides |
TW492882B (en) | 1997-11-28 | 2002-07-01 | Caleb Pharmaceuticals Inc | Cholinergic antagonist plaster composition |
US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
EP2323652A2 (en) * | 2008-08-06 | 2011-05-25 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
JP6170675B2 (ja) * | 2010-01-28 | 2017-07-26 | ラプトール ファーマシューティカルズ インコーポレイテッド | 受容体関連タンパク質(rap)ペプチド−フコシダーゼ阻害薬複合体による肝障害処置のための方法 |
ES2864774T3 (es) * | 2011-12-22 | 2021-10-14 | Centogene Ip Gmbh | Combinación de un compuesto que tiene la capacidad de reorganizar una enzima lisosomal y Ambroxol y/o un derivado de Ambroxol |
EP2890679A4 (en) * | 2012-08-31 | 2016-05-04 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
AR105540A1 (es) | 2015-07-30 | 2017-10-11 | Raptor Pharmaceuticals Inc | Inhibidores de fucosidasas |
-
2016
- 2016-07-29 AR ARP160102325A patent/AR105540A1/es unknown
- 2016-07-29 JP JP2018504163A patent/JP6981961B2/ja active Active
- 2016-07-29 KR KR1020187005356A patent/KR20180030699A/ko not_active Application Discontinuation
- 2016-07-29 AU AU2016298324A patent/AU2016298324A1/en not_active Abandoned
- 2016-07-29 BR BR112018000961A patent/BR112018000961A2/pt not_active Application Discontinuation
- 2016-07-29 CA CA2992033A patent/CA2992033A1/en not_active Abandoned
- 2016-07-29 TW TW105124173A patent/TWI777923B/zh active
- 2016-07-29 CN CN201680044370.2A patent/CN107848970B/zh active Active
- 2016-07-29 MX MX2018001315A patent/MX2018001315A/es unknown
- 2016-07-29 RU RU2018107143A patent/RU2765202C2/ru active
- 2016-07-29 EP EP16748452.6A patent/EP3328832B1/en active Active
- 2016-07-29 WO PCT/US2016/044607 patent/WO2017019925A1/en active Application Filing
- 2016-08-01 US US15/225,188 patent/US9951013B2/en active Active - Reinstated
-
2017
- 2017-12-31 IL IL256662A patent/IL256662B/en active IP Right Grant
-
2018
- 2018-01-30 ZA ZA2018/00638A patent/ZA201800638B/en unknown
- 2018-03-30 US US15/941,247 patent/US10308607B2/en not_active Expired - Fee Related
-
2020
- 2020-12-18 AU AU2020289858A patent/AU2020289858A1/en not_active Abandoned
-
2021
- 2021-07-01 JP JP2021110088A patent/JP2021152078A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2018107143A3 (es) | 2019-12-27 |
TW201713620A (zh) | 2017-04-16 |
AU2016298324A1 (en) | 2018-01-25 |
WO2017019925A1 (en) | 2017-02-02 |
CN107848970A (zh) | 2018-03-27 |
IL256662A (en) | 2018-02-28 |
RU2765202C2 (ru) | 2022-01-26 |
BR112018000961A2 (pt) | 2018-09-18 |
CA2992033A1 (en) | 2017-02-02 |
KR20180030699A (ko) | 2018-03-23 |
EP3328832A1 (en) | 2018-06-06 |
ZA201800638B (en) | 2022-08-31 |
RU2018107143A (ru) | 2019-08-29 |
US10308607B2 (en) | 2019-06-04 |
IL256662B (en) | 2021-06-30 |
TWI777923B (zh) | 2022-09-21 |
CN107848970B (zh) | 2021-07-06 |
JP6981961B2 (ja) | 2021-12-17 |
EP3328832B1 (en) | 2021-03-03 |
US20190077756A1 (en) | 2019-03-14 |
US20170029376A1 (en) | 2017-02-02 |
JP2018522023A (ja) | 2018-08-09 |
US9951013B2 (en) | 2018-04-24 |
AR105540A1 (es) | 2017-10-11 |
AU2020289858A1 (en) | 2021-01-28 |
JP2021152078A (ja) | 2021-09-30 |
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