MX2018001244A - Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh. - Google Patents
Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh.Info
- Publication number
- MX2018001244A MX2018001244A MX2018001244A MX2018001244A MX2018001244A MX 2018001244 A MX2018001244 A MX 2018001244A MX 2018001244 A MX2018001244 A MX 2018001244A MX 2018001244 A MX2018001244 A MX 2018001244A MX 2018001244 A MX2018001244 A MX 2018001244A
- Authority
- MX
- Mexico
- Prior art keywords
- monoclonal antibodies
- seq
- respiratory syncytial
- syncytial virus
- human respiratory
- Prior art date
Links
- 241000711920 Human orthopneumovirus Species 0.000 title abstract 2
- 102000007982 Phosphoproteins Human genes 0.000 title 1
- 108010089430 Phosphoproteins Proteins 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 2
- 210000004408 hybridoma Anatomy 0.000 abstract 2
- 101710177166 Phosphoprotein Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
La presente invención se refiere a anticuerpos monoclonales o fragmentos del mismo que se unen a la proteína P del Virus Respiratorio Sincicial humano (VRSh) que comprenden una región variable de la cadena pesada que tiene una secuencia con al menos un 90%, 95% o 99% de identidad con la SEQ ID No:1 o SEQ ID 5 o una región variable de la cadena liviana que tiene una secuencia con al menos un 90%, 95% o 99% de identidad con la SEQ ID No:2 o SEQ ID No: 6. La invención también proporciona métodos de diagnóstico ex vivo o in vitro para detección del antígeno viral P de VRSh, en los cuales se utilizan los anticuerpos monoclonales producidos y secretados por los hibridomas 2E6/D2 y 6H5/H1. El invento puede ser usado en kits de detección para VRSh, que comprenda los anticuerpos producidos por los hibridomas mencionados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2015002152A CL2015002152A1 (es) | 2015-07-31 | 2015-07-31 | Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh |
| PCT/IB2016/054424 WO2017021815A2 (en) | 2015-07-31 | 2016-07-25 | Monoclonal antibodies specifically for the antigen p of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by rsv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018001244A true MX2018001244A (es) | 2018-04-24 |
Family
ID=56610056
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018001244A MX2018001244A (es) | 2015-07-31 | 2016-07-25 | Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh. |
| MX2022010471A MX2022010471A (es) | 2015-07-31 | 2018-01-29 | Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022010471A MX2022010471A (es) | 2015-07-31 | 2018-01-29 | Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10858419B2 (es) |
| EP (2) | EP3328884B1 (es) |
| CN (1) | CN108474017B (es) |
| AR (1) | AR105541A1 (es) |
| BR (1) | BR112018002031A2 (es) |
| CA (1) | CA2994219C (es) |
| CL (1) | CL2015002152A1 (es) |
| CO (1) | CO2018001010A2 (es) |
| ES (2) | ES2784888T3 (es) |
| MX (2) | MX2018001244A (es) |
| PE (2) | PE20220004A1 (es) |
| PT (2) | PT3517546T (es) |
| RU (1) | RU2716990C2 (es) |
| UY (1) | UY36820A (es) |
| WO (1) | WO2017021815A2 (es) |
| ZA (1) | ZA201800938B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102017127857B4 (de) * | 2017-11-24 | 2023-10-12 | Lipozyt Marker UG (haftungsbeschränkt) | Verwendung des ADIPOQ Genexpressionslevels zur Einordnung eines Probanden in Risikogruppen bei der Prognose oder Diagnose einer Diabetes mellitus Typ II Erkrankung |
| CA3111336A1 (en) * | 2018-09-03 | 2020-03-12 | Pontificia Universidad Catolica De Chile | Specific monoclonal antibody against the n antigen of human respiratory syncytial virus (hrsv) useful for treating infection, detection thereof and diagnosis |
| CL2018003869A1 (es) * | 2018-12-28 | 2021-01-15 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales específicos para la proteína quimérica l del virus de la parainfluenza humana (piv), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por piv |
| EP3825591A1 (en) | 2019-11-22 | 2021-05-26 | Hamilton Sundstrand Corporation | Hydraulic damping valve |
| CN113354734B (zh) * | 2021-07-14 | 2021-12-14 | 北京祥瑞生物制品有限公司 | 一种快速检测病毒的试剂盒及其制备方法 |
| CN115925909B (zh) * | 2022-09-27 | 2023-07-21 | 深圳重链生物科技有限公司 | 抗呼吸道合胞病毒抗体及其相关应用 |
| CN115838419B (zh) * | 2022-09-27 | 2023-06-30 | 深圳重链生物科技有限公司 | 抗呼吸道合胞病毒抗体及其相关应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| US7223410B1 (en) * | 1994-08-05 | 2007-05-29 | Sanofi Pasteur Limited | Inactivated respiratory syncytial viral vaccines |
| US6258529B1 (en) | 1994-12-01 | 2001-07-10 | Oravax, Inc. | PCR amplification of rearranged genomic variable regions of immunoglobulin genes |
| US7527787B2 (en) * | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| WO2003072720A2 (en) * | 2002-02-21 | 2003-09-04 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| TW200501985A (en) | 2002-07-25 | 2005-01-16 | Medimmune Inc | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| WO2004028478A2 (en) | 2002-09-27 | 2004-04-08 | Medimmune Vaccines, Inc. | Functional mutations in respiratory syncytial virus |
| RU2008110058A (ru) * | 2005-08-15 | 2009-09-27 | Арана Терапьютикс Лимитед (Au) | Химерные антитела с областями приматов нового света |
| JP5941615B2 (ja) * | 2008-10-31 | 2016-06-29 | 東レ株式会社 | ヒトｃｘｃｌ１タンパク質の免疫学的測定方法 |
| CL2011003002A1 (es) | 2011-11-25 | 2012-05-25 | Univ Pontificia Catolica Chile | Anticuerpo monoclonal o un fragmento del mismo que se une a la proteina m2-1 del virus respiratorio sincicial (vrs) humano; secuencias nucleotidicas; composicion farmaceutica; metodo de diagnostico de infeccion producida por vrs; kit; y uso de dicho anticuerpo para preparar un medicamento. |
-
2015
- 2015-07-31 CL CL2015002152A patent/CL2015002152A1/es unknown
-
2016
- 2016-07-25 CN CN201680052944.0A patent/CN108474017B/zh active Active
- 2016-07-25 PT PT182037010T patent/PT3517546T/pt unknown
- 2016-07-25 ES ES16832387T patent/ES2784888T3/es active Active
- 2016-07-25 PE PE2021001936A patent/PE20220004A1/es unknown
- 2016-07-25 BR BR112018002031-1A patent/BR112018002031A2/pt active Search and Examination
- 2016-07-25 US US15/748,979 patent/US10858419B2/en active Active
- 2016-07-25 WO PCT/IB2016/054424 patent/WO2017021815A2/en active Application Filing
- 2016-07-25 ES ES18203701T patent/ES2786637T3/es active Active
- 2016-07-25 CA CA2994219A patent/CA2994219C/en active Active
- 2016-07-25 RU RU2018103933A patent/RU2716990C2/ru active
- 2016-07-25 MX MX2018001244A patent/MX2018001244A/es unknown
- 2016-07-25 EP EP16832387.1A patent/EP3328884B1/en active Active
- 2016-07-25 PE PE2018000144A patent/PE20180576A1/es unknown
- 2016-07-25 PT PT168323871T patent/PT3328884T/pt unknown
- 2016-07-25 EP EP18203701.0A patent/EP3517546B1/en active Active
- 2016-07-27 UY UY0001036820A patent/UY36820A/es not_active Application Discontinuation
- 2016-07-29 AR ARP160102326A patent/AR105541A1/es unknown
-
2018
- 2018-01-29 MX MX2022010471A patent/MX2022010471A/es unknown
- 2018-01-30 CO CONC2018/0001010A patent/CO2018001010A2/es unknown
- 2018-02-12 ZA ZA2018/00938A patent/ZA201800938B/en unknown
-
2020
- 2020-11-02 US US17/087,103 patent/US11873331B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018103933A3 (es) | 2019-08-28 |
| PE20180576A1 (es) | 2018-04-04 |
| RU2716990C2 (ru) | 2020-03-17 |
| BR112018002031A2 (pt) | 2018-09-11 |
| CA2994219C (en) | 2024-02-20 |
| CN108474017B (zh) | 2021-08-27 |
| KR20180030919A (ko) | 2018-03-26 |
| EP3328884A2 (en) | 2018-06-06 |
| UY36820A (es) | 2017-01-31 |
| ES2784888T3 (es) | 2020-10-01 |
| MX2022010471A (es) | 2022-09-19 |
| CA2994219A1 (en) | 2017-02-09 |
| EP3328884A4 (en) | 2018-06-06 |
| EP3328884B1 (en) | 2020-01-01 |
| AR105541A1 (es) | 2017-10-11 |
| RU2018103933A (ru) | 2019-08-28 |
| PE20220004A1 (es) | 2022-01-05 |
| PT3328884T (pt) | 2020-04-08 |
| EP3517546A1 (en) | 2019-07-31 |
| ZA201800938B (en) | 2019-07-31 |
| WO2017021815A2 (en) | 2017-02-09 |
| US20180327483A1 (en) | 2018-11-15 |
| CO2018001010A2 (es) | 2018-04-30 |
| EP3517546B1 (en) | 2020-02-26 |
| US10858419B2 (en) | 2020-12-08 |
| ES2786637T3 (es) | 2020-10-13 |
| CN108474017A (zh) | 2018-08-31 |
| PT3517546T (pt) | 2020-05-22 |
| WO2017021815A3 (en) | 2017-05-11 |
| US20210070844A1 (en) | 2021-03-11 |
| US11873331B2 (en) | 2024-01-16 |
| CL2015002152A1 (es) | 2016-06-03 |
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