MX2016014355A - Metodo para seleccionar anticuerpos con interaccion del receptor de fc neonatal (fcrn) modificado. - Google Patents
Metodo para seleccionar anticuerpos con interaccion del receptor de fc neonatal (fcrn) modificado.Info
- Publication number
- MX2016014355A MX2016014355A MX2016014355A MX2016014355A MX2016014355A MX 2016014355 A MX2016014355 A MX 2016014355A MX 2016014355 A MX2016014355 A MX 2016014355A MX 2016014355 A MX2016014355 A MX 2016014355A MX 2016014355 A MX2016014355 A MX 2016014355A
- Authority
- MX
- Mexico
- Prior art keywords
- full length
- positions
- numbering according
- antibodies
- length antibody
- Prior art date
Links
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
- F25D31/002—Liquid coolers, e.g. beverage cooler
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2600/00—Control issues
- F25D2600/04—Controlling heat transfer
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2700/00—Means for sensing or measuring; Sensors therefor
- F25D2700/16—Sensors measuring the temperature of products
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un método para seleccionar un anticuerpo de longitud completa que comprende las etapas de a) generar de un anticuerpo de longitud completa precursor una pluralidad de anticuerpos de longitud completa aleatorizando uno o más residuos de aminoácido seleccionados a partir de los residuos de aminoácido en las posiciones 1-23 en el dominio variable de cadena pesada (numeración de conformidad con Kabat), en las posiciones 55-83 en el dominio variable de cadena ligera (numeración de conformidad con Kabat), en las posiciones 145-174 en el primer dominio constante de cadena pesada (numeración de conformidad con el índice EU) y en las posiciones 180- 97 en el primer dominio constante de cadena pesada (numeración de conformidad con el índice EU), b) determinar la intensidad de unión de cada uno de los anticuerpos de longitud completa a partir de la pluralidad de anticuerpos al receptor Fc neonatal humano (FcRn), y c) seleccionar un anticuerpo de longitud completa a partir de la pluralidad de anticuerpos de longitud completa que tiene una diferente intensidad de unión al FcRn que el anticuerpo de longitud completa precursor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14172180 | 2014-06-12 | ||
PCT/EP2015/062899 WO2015189249A1 (en) | 2014-06-12 | 2015-06-10 | Method for selecting antibodies with modified fcrn interaction |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016014355A true MX2016014355A (es) | 2017-01-27 |
Family
ID=50933041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016014355A MX2016014355A (es) | 2014-06-12 | 2015-06-10 | Metodo para seleccionar anticuerpos con interaccion del receptor de fc neonatal (fcrn) modificado. |
Country Status (10)
Country | Link |
---|---|
US (2) | US20170211876A1 (es) |
EP (1) | EP3155013B1 (es) |
JP (2) | JP6675329B2 (es) |
KR (1) | KR20170015920A (es) |
CN (1) | CN106459191B (es) |
BR (1) | BR112016025393A2 (es) |
CA (1) | CA2946430A1 (es) |
MX (1) | MX2016014355A (es) |
RU (1) | RU2714153C2 (es) |
WO (1) | WO2015189249A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019001989A2 (pt) | 2016-08-02 | 2019-08-20 | Visterra Inc | polipeptídeos projetados e usos dos mesmos |
WO2019077092A1 (en) * | 2017-10-20 | 2019-04-25 | F. Hoffmann-La Roche Ag | METHOD FOR GENERATING MULTISPECIFIC ANTIBODIES FROM MONOSPECIFIC ANTIBODIES |
JP2022512798A (ja) * | 2018-10-25 | 2022-02-07 | エフ.ホフマン-ラ ロシュ アーゲー | 抗体FcRn結合の改変 |
WO2021075930A1 (en) * | 2019-10-16 | 2021-04-22 | Lg Chem, Ltd. | Neonatal fc receptor binding affimers |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1355919B1 (en) * | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
US7361740B2 (en) * | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
KR100973564B1 (ko) * | 2003-05-02 | 2010-08-03 | 젠코어 인코포레이티드 | 최적화된 Fc 변이체 및 그의 제조 방법 |
RU2412200C2 (ru) * | 2004-11-12 | 2011-02-20 | Ксенкор, Инк. | Fc-ВАРИАНТЫ С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ С FcRn |
JP6071165B2 (ja) * | 2007-05-31 | 2017-02-01 | ゲンマブ エー/エス | 安定なIgG4抗体 |
WO2009032782A2 (en) * | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
EP2318436A4 (en) * | 2008-08-14 | 2012-12-19 | Cephalon Australia Pty Ltd | ANTIBODIES OF DIFFERENT DOMAINS |
EP2233500A1 (en) * | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
TWI667257B (zh) * | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
JP5953303B2 (ja) * | 2010-07-29 | 2016-07-20 | ゼンコア インコーポレイテッド | 改変された等電点を有する抗体 |
AU2012323287B2 (en) * | 2011-10-10 | 2018-02-01 | Xencor, Inc. | A method for purifying antibodies |
US9585970B2 (en) * | 2012-06-04 | 2017-03-07 | Novartis Ag | Site-specific labeling methods and molecules produced thereby |
AU2016211280B2 (en) * | 2015-01-30 | 2021-11-25 | Momenta Pharmaceuticals, Inc. | FcRn antibodies and methods of use thereof |
EP4295154A1 (en) * | 2021-02-18 | 2023-12-27 | F. Hoffmann-La Roche AG | Method for resolving complex, multistep antibody interactions |
-
2015
- 2015-06-10 RU RU2016150952A patent/RU2714153C2/ru active
- 2015-06-10 KR KR1020167034666A patent/KR20170015920A/ko not_active Application Discontinuation
- 2015-06-10 JP JP2016572459A patent/JP6675329B2/ja active Active
- 2015-06-10 EP EP15726647.9A patent/EP3155013B1/en active Active
- 2015-06-10 WO PCT/EP2015/062899 patent/WO2015189249A1/en active Application Filing
- 2015-06-10 CA CA2946430A patent/CA2946430A1/en active Pending
- 2015-06-10 MX MX2016014355A patent/MX2016014355A/es active IP Right Grant
- 2015-06-10 CN CN201580031229.4A patent/CN106459191B/zh active Active
- 2015-06-10 BR BR112016025393A patent/BR112016025393A2/pt not_active IP Right Cessation
- 2015-06-10 US US15/317,324 patent/US20170211876A1/en not_active Abandoned
-
2020
- 2020-03-10 JP JP2020040435A patent/JP7050838B2/ja active Active
- 2020-07-27 US US16/939,659 patent/US20210041163A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020114217A (ja) | 2020-07-30 |
US20170211876A1 (en) | 2017-07-27 |
BR112016025393A2 (pt) | 2017-12-12 |
CN106459191B (zh) | 2021-12-10 |
WO2015189249A1 (en) | 2015-12-17 |
EP3155013A1 (en) | 2017-04-19 |
RU2714153C2 (ru) | 2020-02-12 |
EP3155013B1 (en) | 2019-03-27 |
JP7050838B2 (ja) | 2022-04-08 |
CN106459191A (zh) | 2017-02-22 |
JP2017525335A (ja) | 2017-09-07 |
RU2016150952A (ru) | 2018-07-12 |
JP6675329B2 (ja) | 2020-04-01 |
RU2016150952A3 (es) | 2019-02-07 |
CA2946430A1 (en) | 2015-12-17 |
US20210041163A1 (en) | 2021-02-11 |
KR20170015920A (ko) | 2017-02-10 |
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