MX2016010912A - Nuevos compuestos derivados de 6, 7-dihidro-3h-oxazolo [3, 4-a] pirazina-5, 8-diona. - Google Patents

Nuevos compuestos derivados de 6, 7-dihidro-3h-oxazolo [3, 4-a] pirazina-5, 8-diona.

Info

Publication number
MX2016010912A
MX2016010912A MX2016010912A MX2016010912A MX2016010912A MX 2016010912 A MX2016010912 A MX 2016010912A MX 2016010912 A MX2016010912 A MX 2016010912A MX 2016010912 A MX2016010912 A MX 2016010912A MX 2016010912 A MX2016010912 A MX 2016010912A
Authority
MX
Mexico
Prior art keywords
novel
oxazolo
pyrazine
dihydro
compounds
Prior art date
Application number
MX2016010912A
Other languages
English (en)
Other versions
MX369840B (es
Inventor
Luiz Sacurai Sérgio
Eduardo Da Costa Touzarim Carlos
Travanca Toledo Fabiano
Artur De Sousa Bruno
Original Assignee
Biolab Sanus Farmacêutica Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolab Sanus Farmacêutica Ltda filed Critical Biolab Sanus Farmacêutica Ltda
Publication of MX2016010912A publication Critical patent/MX2016010912A/es
Publication of MX369840B publication Critical patent/MX369840B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

La presente invención se refiere a nuevos derivados de 6,7-dihidro-3H-oxazolo[3,4-a]pirazina-5,8-diona o a una mezcla de éstos. La presente invención también contempla composiciones farmacéuticas que comprendan una cantidad eficaz de uno de los nuevos compuestos que son objeto de la presente invención, así como el uso de dichos compuestos y/o derivados como inhibidores de enzimas fosfodiesterasas y el uso de los compuestos y/o derivados en el tratamiento de la disfunción eréctil, de trastornos y/o condiciones tratables con relajación de tejidos y de trastornos tratables con inhibidores de fosfodiesterasas, más específicamente con inhibidores de la PDE-5. Un objetivo adicional de la presente invención es proveer un medicamento que comprenda una cantidad terapéuticamente eficaz de uno de los nuevos compuestos y un método de tratamiento utilizando dichos nuevos compuestos.
MX2016010912A 2014-02-24 2015-02-24 Nuevos compuestos derivados de 6, 7-dihidro-3h-oxazolo [3, 4-a] pirazina-5, 8-diona. MX369840B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461943825P 2014-02-24 2014-02-24
PCT/BR2015/000023 WO2015123748A1 (pt) 2014-02-24 2015-02-24 "NOVOS COMPOSTOS DERIVADOS DE 6,7-DIHIDRO-3H-OXAZOLO [3,4-a] PIRAZINA-5,8-DIONA "

Publications (2)

Publication Number Publication Date
MX2016010912A true MX2016010912A (es) 2016-11-30
MX369840B MX369840B (es) 2019-11-22

Family

ID=53877456

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010912A MX369840B (es) 2014-02-24 2015-02-24 Nuevos compuestos derivados de 6, 7-dihidro-3h-oxazolo [3, 4-a] pirazina-5, 8-diona.

Country Status (19)

Country Link
US (1) US9359378B2 (es)
EP (1) EP3133072B1 (es)
JP (1) JP6636463B2 (es)
KR (1) KR102408431B1 (es)
AR (1) AR099523A1 (es)
AU (1) AU2015221431B2 (es)
BR (1) BR112016019609B1 (es)
CA (1) CA2940225C (es)
CL (1) CL2016002125A1 (es)
ES (1) ES2734063T3 (es)
HU (1) HUE044993T2 (es)
IL (1) IL247330B (es)
MX (1) MX369840B (es)
PL (1) PL3133072T3 (es)
PT (1) PT3133072T (es)
TR (1) TR201910896T4 (es)
UY (1) UY36010A (es)
WO (1) WO2015123748A1 (es)
ZA (1) ZA201606522B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3144770A1 (en) * 2019-07-15 2021-01-21 Biolab Sanus Farmaceutica Ltda Stereoisomers of the compound 3-(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1h-indol-3-yl)-6,7-dihydro-3h-oxazol[3,4-a]pyrazine-5,8-dione and use thereof as an antitumor agent and phosphodiesterase enzyme inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098877A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Pyrazino 1',2':1,6 pyrido 3,4-b indole1,4-dione derivatives
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
AR073522A1 (es) * 2008-09-30 2010-11-10 Biolab Sanus Farmaceutica Ltda Compuestos derivados de 2-(3-metilenodioxi) - benzoil indol
BRPI0903803B1 (pt) * 2009-09-30 2019-07-09 Biolab Sanus Farmacêutica Ltda. Composto, processo de preparação, composição farmacêutica e uso dos compostos
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona

Also Published As

Publication number Publication date
CA2940225C (en) 2021-12-28
KR102408431B1 (ko) 2022-06-13
BR112016019609B1 (pt) 2022-06-14
ZA201606522B (en) 2018-04-25
WO2015123748A1 (pt) 2015-08-27
US9359378B2 (en) 2016-06-07
US20150239903A1 (en) 2015-08-27
IL247330A0 (en) 2016-09-29
AU2015221431A8 (en) 2016-11-24
AU2015221431A1 (en) 2016-09-29
EP3133072A4 (en) 2017-08-09
AR099523A1 (es) 2016-07-27
PL3133072T3 (pl) 2019-10-31
EP3133072A1 (en) 2017-02-22
CA2940225A1 (en) 2015-08-27
JP6636463B2 (ja) 2020-01-29
TR201910896T4 (tr) 2019-08-21
PT3133072T (pt) 2019-07-26
AU2015221431B2 (en) 2018-04-19
BR112016019609A2 (es) 2017-08-22
IL247330B (en) 2020-10-29
UY36010A (es) 2015-09-30
MX369840B (es) 2019-11-22
CL2016002125A1 (es) 2016-12-30
JP2017506263A (ja) 2017-03-02
HUE044993T2 (hu) 2019-11-28
KR20160116028A (ko) 2016-10-06
ES2734063T3 (es) 2019-12-04
EP3133072B1 (en) 2019-05-01

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