MX2016002524A - Formulaciones de aminoglucosidos y fosfomicina en una combinacion que tiene propiedades quimicas mejoradas. - Google Patents

Formulaciones de aminoglucosidos y fosfomicina en una combinacion que tiene propiedades quimicas mejoradas.

Info

Publication number
MX2016002524A
MX2016002524A MX2016002524A MX2016002524A MX2016002524A MX 2016002524 A MX2016002524 A MX 2016002524A MX 2016002524 A MX2016002524 A MX 2016002524A MX 2016002524 A MX2016002524 A MX 2016002524A MX 2016002524 A MX2016002524 A MX 2016002524A
Authority
MX
Mexico
Prior art keywords
combination
aminoglycosides
fosfomycin
ventilator
formulations
Prior art date
Application number
MX2016002524A
Other languages
English (en)
Inventor
Bruce Montgomery Alan
Original Assignee
Cardeas Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardeas Pharma Corp filed Critical Cardeas Pharma Corp
Publication of MX2016002524A publication Critical patent/MX2016002524A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a composiciones antibióticas sinérgicas que tienen perfiles ajustados de pH para preparar una combinación, y la administración en particular para pacientes en riesgo o que padecen neumonía asociada a ventilación (VAP) y bronquitis traqueal asociada a ventilación (VAT). Las composiciones antibióticas que contienen fosfomicina y aminoglucósidos que tienen intervalos de pH determinados previamente y seleccionados de forma individual se preparan y almacenan para combinación antes de aerosolización, preferentemente con un nebulizador en línea diseñado especialmente unido a un equipo de ventilación.
MX2016002524A 2013-08-26 2014-08-26 Formulaciones de aminoglucosidos y fosfomicina en una combinacion que tiene propiedades quimicas mejoradas. MX2016002524A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361870102P 2013-08-26 2013-08-26
PCT/US2014/052778 WO2015031405A1 (en) 2013-08-26 2014-08-26 Formulations of aminoglycosides and fosfomycin in a combination having improved chemical properties

Publications (1)

Publication Number Publication Date
MX2016002524A true MX2016002524A (es) 2016-10-26

Family

ID=51494539

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002524A MX2016002524A (es) 2013-08-26 2014-08-26 Formulaciones de aminoglucosidos y fosfomicina en una combinacion que tiene propiedades quimicas mejoradas.

Country Status (11)

Country Link
US (2) US9486462B2 (es)
EP (1) EP3038599A1 (es)
JP (1) JP2016534122A (es)
KR (1) KR20160048896A (es)
CN (1) CN105705138A (es)
AU (1) AU2014311282A1 (es)
CA (1) CA2922337A1 (es)
MX (1) MX2016002524A (es)
PH (1) PH12016500384A1 (es)
RU (1) RU2691658C2 (es)
WO (1) WO2015031405A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3219305A1 (de) 2016-03-16 2017-09-20 Apostolos Georgopoulos Fosfomycin-formulierung zur parenteralen verabreichung
JP7554484B2 (ja) * 2018-05-14 2024-09-20 ルースターバイオ，インコーポレイテッド 細胞の高張液に由来する細胞外物質に関連する方法及び組成物
US20220233555A1 (en) 2019-05-24 2022-07-28 Stichting Radboud Universitair Medisch Centrum Improved administration of glycylcyclines by inhalation
TW202228792A (zh) 2020-10-09 2022-08-01 殷漢生技股份有限公司 吸入用奈米載體製劑

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327935T3 (es) 2003-11-17 2009-11-05 Nektar Therapeutics Introduccion de un aerosol en un circuito de un ventilador.
JP4745340B2 (ja) 2004-05-17 2011-08-10 コラス・フアーマ・インコーポレイテツド 細菌性呼吸器感染症を治療するためのエーロゾル化されたホスホマイシン／アミノグリコシド組合せ
US20110124589A1 (en) * 2009-11-24 2011-05-26 Gilead Sciences, Inc. Inhaled fosfomycin/tobramycin for the treatment of chronic obstructive pulmonary disease
WO2012030513A2 (en) * 2010-08-30 2012-03-08 Cempra Pharmaceuticals Inc. Methods of treating bacterial infections through pulmonary delivery of fusidic acid
RU2014101763A (ru) 2011-07-12 2015-08-20 Кардис Фарма Корпорейшн Композиции комбинаций амикацина и фосфомицина, способы и системы для лечения вентилятор-ассоциированной пневмонии и вентилятор-ассоциированного трахеоброхита
ES2532667T3 (es) 2011-09-12 2015-03-30 Meiji Seika Pharma Co., Ltd. Composiciones acuosas que contienen arbekacina

Also Published As

Publication number Publication date
CA2922337A1 (en) 2015-03-05
US9486462B2 (en) 2016-11-08
RU2016111355A3 (es) 2018-05-23
AU2014311282A1 (en) 2016-04-21
US20150057241A1 (en) 2015-02-26
PH12016500384A1 (en) 2016-05-16
JP2016534122A (ja) 2016-11-04
US20170296562A1 (en) 2017-10-19
RU2016111355A (ru) 2017-10-03
US10406171B2 (en) 2019-09-10
EP3038599A1 (en) 2016-07-06
KR20160048896A (ko) 2016-05-04
CN105705138A (zh) 2016-06-22
RU2691658C2 (ru) 2019-06-17
WO2015031405A1 (en) 2015-03-05

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