MX2015014825A - Ensayos para la identificacion de compuestos que modulan el sabor amargo. - Google Patents
Ensayos para la identificacion de compuestos que modulan el sabor amargo.Info
- Publication number
- MX2015014825A MX2015014825A MX2015014825A MX2015014825A MX2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A
- Authority
- MX
- Mexico
- Prior art keywords
- bitter taste
- identifying compounds
- agonists
- present
- provides methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Seasonings (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
La presente invención se basa en el descubrimiento de los solicitantes, divulgado en la presente, de los agonistas para los receptores TAS2R TAS2R1; TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R38, TAS2R39, TAS2R44, TAS2R46 Y TAS2R60. La asignación de los agonistas para estos recetores hacen posible los ensayos para la identificación de compuestos que modulen el sabor amargo. Por ejemplo, la presente invención proporciona métodos para identificar compuestos que inhiban el sabor amargo debido a estos agonistas. La presente invención proporciona métodos para identificar compuestos que inhiban de manera selectiva el sabor amargo debido a estos agonistas. Además, la presente invención proporciona métodos para identificar compuestos que imiten el sabor amargo debido a estos agonistas. La presente invención también proporciona métodos para identificar compuestos que mejoren el sabor amargo debido a estos agonistas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361815592P | 2013-04-24 | 2013-04-24 | |
PCT/US2014/035147 WO2014176336A1 (en) | 2013-04-24 | 2014-04-23 | Assays for identifying compounds that modulate bitter taste |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015014825A true MX2015014825A (es) | 2016-05-31 |
Family
ID=51792362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014825A MX2015014825A (es) | 2013-04-24 | 2014-04-23 | Ensayos para la identificacion de compuestos que modulan el sabor amargo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US9927424B2 (es) |
EP (1) | EP2989464B1 (es) |
JP (1) | JP2016523512A (es) |
CN (1) | CN105358983B (es) |
AU (1) | AU2014257086A1 (es) |
BR (1) | BR112015026901A2 (es) |
CA (1) | CA2910161A1 (es) |
MX (1) | MX2015014825A (es) |
RU (1) | RU2015144371A (es) |
SG (1) | SG11201508572UA (es) |
WO (1) | WO2014176336A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017019890A1 (en) * | 2015-07-28 | 2017-02-02 | Mars, Incorporated | Screening methods using canine t2r receptors and pet food products and compositions identified using the same |
CN110553983B (zh) * | 2019-09-05 | 2022-03-04 | 东北农业大学 | 一种牛奶中山梨酸钾的快速检测方法 |
JP2022546204A (ja) * | 2019-09-09 | 2022-11-04 | フィルメニッヒ インコーポレイテッド | 苦味受容体ブロッカー及びその同定方法 |
EP4142507A1 (en) | 2020-04-29 | 2023-03-08 | Bunge Loders Croklaan B.V. | Composition, confectionery product and process |
CN112521449B (zh) * | 2020-11-18 | 2022-04-22 | 渤海大学 | 两种具有苦味抑制作用的活性肽 |
WO2023205647A1 (en) * | 2022-04-19 | 2023-10-26 | Firmenich Incorporated | Reduction of bitter taste of active pharmaceutical ingredients and related assays and screening methods |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL118460A (en) | 1996-05-28 | 1999-09-22 | Dead Sea Works Ltd | Edible salt mixture |
WO2000038536A2 (en) | 1998-12-23 | 2000-07-06 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
US6692965B1 (en) | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
CN101397563A (zh) * | 2000-04-07 | 2009-04-01 | 塞诺米克斯公司 | T2r味觉受体及其编码基因 |
US8030008B2 (en) * | 2001-04-05 | 2011-10-04 | Senomyx, Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
AU2002318229B2 (en) * | 2001-07-10 | 2008-03-13 | Senomyx, Inc. | Use of specific T2R taste receptors to identify compounds that block bitter taste |
US20030039968A1 (en) | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
EP1543122B1 (en) | 2002-09-25 | 2009-11-18 | Deutsches Institut für Ernährungsforschung | Bitter taste receptors |
KR20100063144A (ko) | 2004-02-18 | 2010-06-10 | 크로모셀 코포레이션 | 신호 프로브를 이용하는 방법 및 물질 |
US7829299B2 (en) | 2004-11-18 | 2010-11-09 | Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts | Agonists of bitter taste receptors and uses thereof |
US7939276B2 (en) | 2005-06-22 | 2011-05-10 | Senomyx, Inc. | Assays which screen for compounds that modulate bitter taste of chlorogenic lactone compounds |
US7923047B2 (en) | 2006-06-30 | 2011-04-12 | Conagra Foods Rdm, Inc. | Seasoning and method for seasoning a food product while reducing dietary sodium intake |
US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
WO2008119197A1 (en) | 2007-03-30 | 2008-10-09 | Givaudan Sa | 4-(2, 2, 3-trimethylcyclopentyl) butanoic acid used as an off-note masking agent in consumables |
ATE555670T1 (de) | 2007-03-30 | 2012-05-15 | Givaudan Sa | Off-note-blockierende sensorische organische verbindungen |
KR20100016044A (ko) | 2007-03-30 | 2010-02-12 | 지보당 에스아 | 조절제의 동정 방법 |
EP1983342A1 (en) | 2007-04-18 | 2008-10-22 | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand | Antogonists of bitter taste receptors and uses thereof |
CN101355441B (zh) | 2007-07-27 | 2012-04-04 | 华为技术有限公司 | 一种配置操作管理维护属性的方法、系统及设备 |
US8076491B2 (en) | 2007-08-21 | 2011-12-13 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
CN103525751B (zh) | 2008-02-01 | 2017-04-12 | 克罗莫塞尔公司 | 细胞系以及制备和使用其的方法 |
EP2300830B1 (en) | 2008-06-13 | 2015-05-20 | Givaudan SA | Methods of identifying modulators of the bitter taste receptor tas2r44 |
EP2329263A1 (en) | 2008-08-07 | 2011-06-08 | Givaudan SA | Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46 |
JP6297769B2 (ja) | 2009-02-02 | 2018-03-20 | クロモセル コーポレーション | 新規の細胞株および方法 |
WO2010099983A1 (en) | 2009-03-06 | 2010-09-10 | Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke | Methods for isolating agonists and antagonists of taste receptors |
US8673578B2 (en) | 2009-10-27 | 2014-03-18 | Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke | Methods of identifying antagonists of the hTAS2R46 bitter taste receptor |
US20130040317A1 (en) | 2011-08-08 | 2013-02-14 | The University Of North Carolina At Chapel Hill | Cell lines comprising endogenous taste receptors and their uses |
IN2014MN00714A (es) * | 2011-10-20 | 2015-07-03 | Chromocell Corp |
-
2014
- 2014-04-23 RU RU2015144371A patent/RU2015144371A/ru not_active Application Discontinuation
- 2014-04-23 AU AU2014257086A patent/AU2014257086A1/en not_active Abandoned
- 2014-04-23 WO PCT/US2014/035147 patent/WO2014176336A1/en active Application Filing
- 2014-04-23 CN CN201480036118.8A patent/CN105358983B/zh not_active Expired - Fee Related
- 2014-04-23 CA CA2910161A patent/CA2910161A1/en not_active Abandoned
- 2014-04-23 BR BR112015026901A patent/BR112015026901A2/pt not_active Application Discontinuation
- 2014-04-23 US US14/786,876 patent/US9927424B2/en not_active Expired - Fee Related
- 2014-04-23 MX MX2015014825A patent/MX2015014825A/es unknown
- 2014-04-23 SG SG11201508572UA patent/SG11201508572UA/en unknown
- 2014-04-23 EP EP14787491.1A patent/EP2989464B1/en not_active Not-in-force
- 2014-04-23 JP JP2016510756A patent/JP2016523512A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2014257086A1 (en) | 2015-11-12 |
CN105358983A (zh) | 2016-02-24 |
US20160069860A1 (en) | 2016-03-10 |
JP2016523512A (ja) | 2016-08-12 |
CN105358983B (zh) | 2018-08-03 |
SG11201508572UA (en) | 2015-11-27 |
CA2910161A1 (en) | 2014-10-30 |
US9927424B2 (en) | 2018-03-27 |
BR112015026901A2 (pt) | 2017-11-14 |
RU2015144371A (ru) | 2017-05-29 |
WO2014176336A1 (en) | 2014-10-30 |
EP2989464A1 (en) | 2016-03-02 |
EP2989464A4 (en) | 2016-12-07 |
EP2989464B1 (en) | 2018-12-26 |
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