MX2015014825A - Ensayos para la identificacion de compuestos que modulan el sabor amargo. - Google Patents

Ensayos para la identificacion de compuestos que modulan el sabor amargo.

Info

Publication number
MX2015014825A
MX2015014825A MX2015014825A MX2015014825A MX2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A MX 2015014825 A MX2015014825 A MX 2015014825A
Authority
MX
Mexico
Prior art keywords
bitter taste
identifying compounds
agonists
present
provides methods
Prior art date
Application number
MX2015014825A
Other languages
English (en)
Inventor
Harish Radhakrishna
Maya Jenkins
Jonathan Anobile
Original Assignee
Chromocell Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromocell Corp filed Critical Chromocell Corp
Publication of MX2015014825A publication Critical patent/MX2015014825A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seasonings (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se basa en el descubrimiento de los solicitantes, divulgado en la presente, de los agonistas para los receptores TAS2R TAS2R1; TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R38, TAS2R39, TAS2R44, TAS2R46 Y TAS2R60. La asignación de los agonistas para estos recetores hacen posible los ensayos para la identificación de compuestos que modulen el sabor amargo. Por ejemplo, la presente invención proporciona métodos para identificar compuestos que inhiban el sabor amargo debido a estos agonistas. La presente invención proporciona métodos para identificar compuestos que inhiban de manera selectiva el sabor amargo debido a estos agonistas. Además, la presente invención proporciona métodos para identificar compuestos que imiten el sabor amargo debido a estos agonistas. La presente invención también proporciona métodos para identificar compuestos que mejoren el sabor amargo debido a estos agonistas.
MX2015014825A 2013-04-24 2014-04-23 Ensayos para la identificacion de compuestos que modulan el sabor amargo. MX2015014825A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361815592P 2013-04-24 2013-04-24
PCT/US2014/035147 WO2014176336A1 (en) 2013-04-24 2014-04-23 Assays for identifying compounds that modulate bitter taste

Publications (1)

Publication Number Publication Date
MX2015014825A true MX2015014825A (es) 2016-05-31

Family

ID=51792362

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014825A MX2015014825A (es) 2013-04-24 2014-04-23 Ensayos para la identificacion de compuestos que modulan el sabor amargo.

Country Status (11)

Country Link
US (1) US9927424B2 (es)
EP (1) EP2989464B1 (es)
JP (1) JP2016523512A (es)
CN (1) CN105358983B (es)
AU (1) AU2014257086A1 (es)
BR (1) BR112015026901A2 (es)
CA (1) CA2910161A1 (es)
MX (1) MX2015014825A (es)
RU (1) RU2015144371A (es)
SG (1) SG11201508572UA (es)
WO (1) WO2014176336A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180372721A1 (en) * 2015-07-28 2018-12-27 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN110553983B (zh) * 2019-09-05 2022-03-04 东北农业大学 一种牛奶中山梨酸钾的快速检测方法
CN114207441A (zh) * 2019-09-09 2022-03-18 弗门尼舍公司 苦味受体阻滞剂及其鉴定方法
JP2023523399A (ja) 2020-04-29 2023-06-05 ブンゲ・ローデルス・クロックラーン・ベー・フェー 組成物、菓子製品、およびプロセス
CN112521449B (zh) * 2020-11-18 2022-04-22 渤海大学 两种具有苦味抑制作用的活性肽
WO2023205647A1 (en) * 2022-04-19 2023-10-26 Firmenich Incorporated Reduction of bitter taste of active pharmaceutical ingredients and related assays and screening methods

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IL118460A (en) 1996-05-28 1999-09-22 Dead Sea Works Ltd Edible salt mixture
ES2337322T3 (es) 1998-12-23 2010-04-22 Mount Sinai School Of Medicine Of New York University Inhibidores de la respuesta al sabor amargo.
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
CN101397563A (zh) * 2000-04-07 2009-04-01 塞诺米克斯公司 T2r味觉受体及其编码基因
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US8030008B2 (en) * 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US20030039968A1 (en) 2001-07-10 2003-02-27 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
CA2452337A1 (en) * 2001-07-10 2003-01-23 Senomyx, Inc. Use of specific t2r taste receptors to identify compounds that block bitter taste
DE60330159D1 (de) 2002-09-25 2009-12-31 Deutsches Inst Ernaehrungsfors Bittergeschmack-rezeptoren
CN104109712A (zh) 2004-02-18 2014-10-22 克罗莫塞尔公司 使用信号探针的方法和材料
US7829299B2 (en) 2004-11-18 2010-11-09 Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts Agonists of bitter taste receptors and uses thereof
AU2006262399A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human T2R recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
WO2008119197A1 (en) 2007-03-30 2008-10-09 Givaudan Sa 4-(2, 2, 3-trimethylcyclopentyl) butanoic acid used as an off-note masking agent in consumables
WO2008119195A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Methods to identify modulators
WO2008119196A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Off-note blocking sensory organic compounds
EP1983342A1 (en) 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
CN101355441B (zh) 2007-07-27 2012-04-04 华为技术有限公司 一种配置操作管理维护属性的方法、系统及设备
US8076491B2 (en) * 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
AU2009215106B2 (en) 2008-02-01 2015-07-23 Chromocell Corporation Cell lines and methods for making and using them
WO2009149577A1 (en) 2008-06-13 2009-12-17 Givaudan Sa Methods of identifying modulators of the bitter taste receptor tas2r44
EP2329263A1 (en) 2008-08-07 2011-06-08 Givaudan SA Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
JP6297769B2 (ja) 2009-02-02 2018-03-20 クロモセル コーポレーション 新規の細胞株および方法
EP2404172A1 (en) 2009-03-06 2012-01-11 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating agonists and antagonists of taste receptors
WO2011050955A1 (en) 2009-10-27 2011-05-05 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Antagonists and agonists of bitter taste receptors and uses thereof
WO2013022947A1 (en) * 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
SG11201401268RA (en) * 2011-10-20 2014-05-29 Chromocell Corp Assays for identifying compounds that modulate bitter taste

Also Published As

Publication number Publication date
EP2989464B1 (en) 2018-12-26
RU2015144371A (ru) 2017-05-29
SG11201508572UA (en) 2015-11-27
US9927424B2 (en) 2018-03-27
WO2014176336A1 (en) 2014-10-30
CA2910161A1 (en) 2014-10-30
EP2989464A4 (en) 2016-12-07
EP2989464A1 (en) 2016-03-02
CN105358983A (zh) 2016-02-24
CN105358983B (zh) 2018-08-03
BR112015026901A2 (pt) 2017-11-14
AU2014257086A1 (en) 2015-11-12
US20160069860A1 (en) 2016-03-10
JP2016523512A (ja) 2016-08-12

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