MX2015012603A - Formación de bis-3,6-(4-aminobutil)-2,5-dicetopiperazina n-protegida a través de un amino ester cíclico alfa-n-protegido. - Google Patents

Formación de bis-3,6-(4-aminobutil)-2,5-dicetopiperazina n-protegida a través de un amino ester cíclico alfa-n-protegido.

Info

Publication number
MX2015012603A
MX2015012603A MX2015012603A MX2015012603A MX2015012603A MX 2015012603 A MX2015012603 A MX 2015012603A MX 2015012603 A MX2015012603 A MX 2015012603A MX 2015012603 A MX2015012603 A MX 2015012603A MX 2015012603 A MX2015012603 A MX 2015012603A
Authority
MX
Mexico
Prior art keywords
protected
diketopiperaz
aminobutyl
ine
formation
Prior art date
Application number
MX2015012603A
Other languages
English (en)
Inventor
John J Freeman
Otto Phanstiel
Williams Elliot Bay
Kelly Sullivan Kraft
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX2015012603A publication Critical patent/MX2015012603A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La proporciona un método para la síntesis de 3,6-aminoalquil-2,5-d icetopiperazinas N-protegidas. El método incluye obtener un amino éster activo a-N protegido cíclico y adicionarlo a una mezcla de un catalizador de amina en un solvente orgánico.
MX2015012603A 2013-03-15 2014-03-14 Formación de bis-3,6-(4-aminobutil)-2,5-dicetopiperazina n-protegida a través de un amino ester cíclico alfa-n-protegido. MX2015012603A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798016P 2013-03-15 2013-03-15
PCT/US2014/028228 WO2014144003A1 (en) 2013-03-15 2014-03-14 Formation of n-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-n-protected amino ester

Publications (1)

Publication Number Publication Date
MX2015012603A true MX2015012603A (es) 2016-06-10

Family

ID=50687647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012603A MX2015012603A (es) 2013-03-15 2014-03-14 Formación de bis-3,6-(4-aminobutil)-2,5-dicetopiperazina n-protegida a través de un amino ester cíclico alfa-n-protegido.

Country Status (14)

Country Link
US (7) US8962836B2 (es)
EP (1) EP2970150B1 (es)
JP (1) JP6402172B2 (es)
KR (1) KR20150131356A (es)
CN (2) CN105143192B (es)
AU (1) AU2014227938B2 (es)
BR (1) BR112015023224B1 (es)
CA (1) CA2904685C (es)
HK (1) HK1220177A1 (es)
IL (1) IL240778A0 (es)
MX (1) MX2015012603A (es)
RU (1) RU2015138569A (es)
SG (1) SG11201507132UA (es)
WO (1) WO2014144003A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144003A1 (en) 2013-03-15 2014-09-18 Mannkind Corp. Formation of n-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-n-protected amino ester

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407203A (en) * 1965-03-22 1968-10-22 Union Carbide Corp Novel process for the preparation of diketopiperazines
FR2374910A1 (fr) 1976-10-23 1978-07-21 Choay Sa Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
AU610083B2 (en) 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
DE19903268A1 (de) 1999-01-28 2000-08-03 Degussa Verfahren zur Decarbamoylierung von N-carbamoylgeschützten Verbindungen, neue Carbonsäureanhydride und deren Verwendung
EP1786784B1 (en) * 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
CN101851213A (zh) * 2010-06-21 2010-10-06 于清 3，6-双(4-双反丁烯二酰基氨丁基)-2，5-二酮哌嗪及其盐取代物的合成方法
EP2673265B1 (en) * 2011-02-10 2016-10-19 MannKind Corporation Formation of n-protected bis-3,6-(4-aminoalkyl) -2,5,diketopiperazine
WO2014144003A1 (en) * 2013-03-15 2014-09-18 Mannkind Corp. Formation of n-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-n-protected amino ester

Also Published As

Publication number Publication date
US20200199082A1 (en) 2020-06-25
CN105143192A (zh) 2015-12-09
US9944609B2 (en) 2018-04-17
US11345668B2 (en) 2022-05-31
US20150259301A1 (en) 2015-09-17
US20220289687A1 (en) 2022-09-15
CN105143192B (zh) 2018-01-23
WO2014144003A1 (en) 2014-09-18
US20210107880A1 (en) 2021-04-15
EP2970150B1 (en) 2018-09-19
KR20150131356A (ko) 2015-11-24
CN107935942B (zh) 2021-06-15
JP2016516718A (ja) 2016-06-09
SG11201507132UA (en) 2015-10-29
AU2014227938B2 (en) 2018-07-26
EP2970150A1 (en) 2016-01-20
CA2904685A1 (en) 2014-09-18
US8962836B2 (en) 2015-02-24
US9187433B2 (en) 2015-11-17
IL240778A0 (en) 2015-10-29
RU2015138569A (ru) 2017-04-26
BR112015023224A2 (pt) 2017-07-18
HK1220177A1 (zh) 2017-04-28
CA2904685C (en) 2022-05-03
BR112015023224B1 (pt) 2021-03-30
JP6402172B2 (ja) 2018-10-10
US10577331B2 (en) 2020-03-03
US20180230107A1 (en) 2018-08-16
CN107935942A (zh) 2018-04-20
US20160137614A1 (en) 2016-05-19
US10870628B2 (en) 2020-12-22
US20140288304A1 (en) 2014-09-25
AU2014227938A1 (en) 2015-09-24

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