MX2015005808A - Mutaciones de proteina de envoltura de flavivirus que afectan el desensamble de viriones. - Google Patents
Mutaciones de proteina de envoltura de flavivirus que afectan el desensamble de viriones.Info
- Publication number
- MX2015005808A MX2015005808A MX2015005808A MX2015005808A MX2015005808A MX 2015005808 A MX2015005808 A MX 2015005808A MX 2015005808 A MX2015005808 A MX 2015005808A MX 2015005808 A MX2015005808 A MX 2015005808A MX 2015005808 A MX2015005808 A MX 2015005808A
- Authority
- MX
- Mexico
- Prior art keywords
- envelope protein
- mutations affecting
- protein mutations
- flavivirus envelope
- flavivirus
- Prior art date
Links
- 241000710831 Flavivirus Species 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title abstract 3
- 101710091045 Envelope protein Proteins 0.000 title abstract 2
- 101710188315 Protein X Proteins 0.000 title abstract 2
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 2
- 210000002845 virion Anatomy 0.000 title 1
- 239000000539 dimer Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Credit Cards Or The Like (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Abstract
Se realizan mutaciones en la interfase de contacto monomérica central de la proteína de la envoltura del flavivirus las cuales modulan la infectividad del flavivirus; las mutaciones reducen la habilidad del dímero de la envoltura a disociar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/671,111 US9267114B2 (en) | 2012-11-07 | 2012-11-07 | Flavivirus envelope protein mutations affecting virion disassembly |
PCT/US2013/068616 WO2014074535A2 (en) | 2012-11-07 | 2013-11-06 | Flavivirus envelope protein mutations affecting virion disassembly |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015005808A true MX2015005808A (es) | 2016-02-25 |
Family
ID=50622575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005808A MX2015005808A (es) | 2012-11-07 | 2013-11-06 | Mutaciones de proteina de envoltura de flavivirus que afectan el desensamble de viriones. |
Country Status (9)
Country | Link |
---|---|
US (1) | US9267114B2 (es) |
EP (1) | EP2916865A4 (es) |
JP (1) | JP2015535302A (es) |
CN (1) | CN104918635A (es) |
AU (1) | AU2013341356A1 (es) |
CA (1) | CA2890406A1 (es) |
EA (1) | EA201590888A1 (es) |
MX (1) | MX2015005808A (es) |
WO (1) | WO2014074535A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201413086D0 (en) | 2014-07-23 | 2014-09-03 | Imp Innovations Ltd And Inst Pasteur | Methods |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
CN105087607A (zh) * | 2015-09-28 | 2015-11-25 | 山东出入境检验检疫局检验检疫技术中心 | 鸭坦布苏病毒e蛋白第三结构域原核表达的方法及其应用 |
JP2018531256A (ja) | 2015-10-07 | 2018-10-25 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | デングウイルスワクチンおよび診断のための方法および組成物 |
EP3364950A4 (en) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | VACCINES AGAINST TROPICAL DISEASES |
EP3184119A1 (en) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
US20170354729A1 (en) * | 2016-03-16 | 2017-12-14 | Novavax, Inc. | Vaccine compositions containing modified zika virus antigens |
US11434261B2 (en) | 2016-07-27 | 2022-09-06 | Hawaii Biotech Inc. | Optimized Zika virus envelope gene and expression thereof |
WO2018071405A1 (en) * | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
WO2018098133A1 (en) * | 2016-11-28 | 2018-05-31 | Medigen, Inc. | Vaccines against infectious diseases caused by positive stranded rna viruses |
EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | VERY POWERFUL IMMUNOGENIC COMPOSITIONS |
US10653767B2 (en) | 2017-09-14 | 2020-05-19 | Modernatx, Inc. | Zika virus MRNA vaccines |
CN114807232A (zh) * | 2022-05-12 | 2022-07-29 | 中国人民解放军海军军医大学 | 一株西尼罗病毒感染性克隆的构建及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
US20110131679A2 (en) | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
US7214786B2 (en) | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
US20050002968A1 (en) | 2002-01-15 | 2005-01-06 | Monath Thomas P. | Flavivirus vaccines |
ES2337893T3 (es) | 2002-11-15 | 2010-04-30 | Sanofi Pasteur Biologics Co. | Vacuna del virus del nilo occidental. |
US20070036827A1 (en) | 2003-10-29 | 2007-02-15 | The University Of Queensland | West nile virus vaccine |
US7459163B2 (en) | 2004-02-25 | 2008-12-02 | University Of Kansas | Infectious DNA as a vaccine against west nile and other flaviviruses |
SG156666A1 (en) | 2004-10-20 | 2009-11-26 | Acambis Inc | Vaccines against japanese encephalitis virus and west nile virus |
US7455842B2 (en) | 2005-12-05 | 2008-11-25 | University Of Kansas | Chimeric West Nile viruses and uses thereof |
JP5167155B2 (ja) | 2006-03-09 | 2013-03-21 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | ペプチド結合に基づく多数の細胞株のプロファイリングに関連した組成物および方法 |
US9868781B2 (en) | 2008-06-02 | 2018-01-16 | Cornell University | Antibodies for ubiquitinated proteins |
-
2012
- 2012-11-07 US US13/671,111 patent/US9267114B2/en not_active Expired - Fee Related
-
2013
- 2013-11-06 CA CA2890406A patent/CA2890406A1/en not_active Abandoned
- 2013-11-06 MX MX2015005808A patent/MX2015005808A/es unknown
- 2013-11-06 AU AU2013341356A patent/AU2013341356A1/en not_active Abandoned
- 2013-11-06 WO PCT/US2013/068616 patent/WO2014074535A2/en active Application Filing
- 2013-11-06 JP JP2015541863A patent/JP2015535302A/ja active Pending
- 2013-11-06 EA EA201590888A patent/EA201590888A1/ru unknown
- 2013-11-06 EP EP13852752.8A patent/EP2916865A4/en not_active Withdrawn
- 2013-11-06 CN CN201380069000.0A patent/CN104918635A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EA201590888A1 (ru) | 2016-02-29 |
EP2916865A4 (en) | 2016-05-25 |
WO2014074535A3 (en) | 2014-07-17 |
AU2013341356A1 (en) | 2015-05-21 |
JP2015535302A (ja) | 2015-12-10 |
EP2916865A2 (en) | 2015-09-16 |
WO2014074535A9 (en) | 2014-09-04 |
CN104918635A (zh) | 2015-09-16 |
US9267114B2 (en) | 2016-02-23 |
CA2890406A1 (en) | 2014-05-15 |
US20140127261A1 (en) | 2014-05-08 |
WO2014074535A2 (en) | 2014-05-15 |
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