MX2015000056A - Derivados de imidazo[2,1b]tiazol, su preparación y su uso como medicamentos. - Google Patents
Derivados de imidazo[2,1b]tiazol, su preparación y su uso como medicamentos.Info
- Publication number
- MX2015000056A MX2015000056A MX2015000056A MX2015000056A MX2015000056A MX 2015000056 A MX2015000056 A MX 2015000056A MX 2015000056 A MX2015000056 A MX 2015000056A MX 2015000056 A MX2015000056 A MX 2015000056A MX 2015000056 A MX2015000056 A MX 2015000056A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- general formula
- maleate
- methyl
- thiazole
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims abstract description 14
- UFBBWLWUIISIPW-UHFFFAOYSA-N imidazo[2,1-b][1,3]thiazole Chemical class C1=CSC2=NC=CN21 UFBBWLWUIISIPW-UHFFFAOYSA-N 0.000 title abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 54
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- 150000001875 compounds Chemical class 0.000 claims description 151
- -1 alkyl radical Chemical class 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 229910052736 halogen Inorganic materials 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 19
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 19
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
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- 125000005842 heteroatom Chemical group 0.000 claims description 12
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 10
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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- YAEAAMWSBICPFO-UHFFFAOYSA-N 2-phenyl-6-(2-pyrrolidin-1-ylethoxymethyl)imidazo[2,1-b][1,3]thiazole Chemical compound C=1N2C=C(C=3C=CC=CC=3)SC2=NC=1COCCN1CCCC1 YAEAAMWSBICPFO-UHFFFAOYSA-N 0.000 claims description 2
- AMJCBCYLUQPKJF-UHFFFAOYSA-N 6-[2-(azepan-1-yl)ethoxymethyl]-2-phenylimidazo[2,1-b][1,3]thiazole Chemical compound C=1N2C=C(C=3C=CC=CC=3)SC2=NC=1COCCN1CCCCCC1 AMJCBCYLUQPKJF-UHFFFAOYSA-N 0.000 claims description 2
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Landscapes
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Applications Claiming Priority (2)
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| EP12382269.4A EP2682395A1 (en) | 2012-07-04 | 2012-07-04 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments |
| PCT/EP2013/064113 WO2014006130A1 (en) | 2012-07-04 | 2013-07-04 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS |
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| EP3402779A1 (en) * | 2016-01-15 | 2018-11-21 | Esteve Pharmaceuticals, S.A. | 3-ethyl-3-phenylazepane derivatives having multimodal activity against pain |
| WO2020127735A1 (en) * | 2018-12-20 | 2020-06-25 | Intervet International B.V. | New methods of producing (2-amino-4-[6-(4-fluorophenyl)-2-[(4-methyl-1-piperazinyl)methyl]imidazo[2,1-b]thiazol-5-yl]-pyrimidine |
| CN117203211B (zh) * | 2021-11-29 | 2025-08-19 | 中国海洋大学 | 咪唑并噻唑衍生物及其制备方法与应用 |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
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| CH621126A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-07 | 1981-01-15 | Plantex Ltd | |
| DE2823686A1 (de) * | 1978-05-31 | 1979-12-06 | Bayer Ag | Imidazo eckige klammer auf 2.1-b eckige klammer zu eckige klammer auf 1.3.4 eckige klammer zu -thiadiazole |
| DE3329621A1 (de) * | 1983-08-17 | 1985-02-28 | Bayer Ag, 5090 Leverkusen | Aminoalkyl-imidazothiadiazol-alkencarbonsaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln |
| US7229480B2 (en) | 2004-02-13 | 2007-06-12 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| PL1781618T3 (pl) * | 2004-08-27 | 2013-03-29 | Esteve Labor Dr | Inhibitory receptora sigma |
| EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| US20060156484A1 (en) | 2005-01-14 | 2006-07-20 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| CN101277965A (zh) * | 2005-08-04 | 2008-10-01 | 西特里斯药业公司 | 作为SIRTUIN调节化合物的咪唑并[2,1-b]噻唑衍生物 |
| EP1910380A1 (en) | 2005-08-04 | 2008-04-16 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| EP1829869A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands |
| EP1847542A1 (en) | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
| EP1982714A1 (en) * | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-amines |
| BRPI0812360A2 (pt) | 2007-05-21 | 2015-01-27 | Sgx Pharmaceuticals Inc | Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase |
| JP5410431B2 (ja) | 2007-09-27 | 2014-02-05 | セントロ ナシオナル デ インベスティガシオネス オンコロヒカス（セエネイオ） | イミダゾロチアジアゾール類のプロテインキナーゼ阻害剤としての使用 |
| EP2053052A1 (en) * | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
| EP2070933A1 (en) | 2007-12-07 | 2009-06-17 | Laboratorios del Dr. Esteve S.A. | Tricyclic triazolic compounds |
| EP2395003A1 (en) * | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
-
2012
- 2012-07-04 EP EP12382269.4A patent/EP2682395A1/en not_active Withdrawn
-
2013
- 2013-07-04 PT PT137329967T patent/PT2870164T/pt unknown
- 2013-07-04 IN IN68MUN2015 patent/IN2015MN00068A/en unknown
- 2013-07-04 CN CN201380041504.1A patent/CN104520304B/zh not_active Expired - Fee Related
- 2013-07-04 US US14/412,257 patent/US9617281B2/en not_active Expired - Fee Related
- 2013-07-04 JP JP2015519224A patent/JP6401156B2/ja not_active Expired - Fee Related
- 2013-07-04 MX MX2015000056A patent/MX2015000056A/es unknown
- 2013-07-04 EP EP13732996.7A patent/EP2870164B1/en not_active Not-in-force
- 2013-07-04 ES ES13732996.7T patent/ES2607183T3/es active Active
- 2013-07-04 WO PCT/EP2013/064113 patent/WO2014006130A1/en active Application Filing
- 2013-07-04 CA CA2878339A patent/CA2878339A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014006130A1 (en) | 2014-01-09 |
| EP2870164B1 (en) | 2016-09-14 |
| HK1210149A1 (en) | 2016-04-15 |
| US9617281B2 (en) | 2017-04-11 |
| PT2870164T (pt) | 2016-12-21 |
| IN2015MN00068A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-10-16 |
| JP6401156B2 (ja) | 2018-10-03 |
| ES2607183T3 (es) | 2017-03-29 |
| CN104520304B (zh) | 2017-02-22 |
| US20150166574A1 (en) | 2015-06-18 |
| EP2682395A1 (en) | 2014-01-08 |
| EP2870164A1 (en) | 2015-05-13 |
| JP2015521994A (ja) | 2015-08-03 |
| CN104520304A (zh) | 2015-04-15 |
| CA2878339A1 (en) | 2014-01-09 |
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