MX2014014657A - Heterociclos bicíclicos capaces de modular las respuestas de los linfocitos t, y métodos de uso de los mismos. - Google Patents
Heterociclos bicíclicos capaces de modular las respuestas de los linfocitos t, y métodos de uso de los mismos.Info
- Publication number
- MX2014014657A MX2014014657A MX2014014657A MX2014014657A MX2014014657A MX 2014014657 A MX2014014657 A MX 2014014657A MX 2014014657 A MX2014014657 A MX 2014014657A MX 2014014657 A MX2014014657 A MX 2014014657A MX 2014014657 A MX2014014657 A MX 2014014657A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- alkyl
- cycloalkyl
- substituents
- heterocyclic compound
- Prior art date
Links
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261654398P | 2012-06-01 | 2012-06-01 | |
| PCT/EP2013/061328 WO2013178815A1 (en) | 2012-06-01 | 2013-05-31 | Bicyclic heterocycles capable of modulating t-cell responses, and methods of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014014657A true MX2014014657A (es) | 2015-08-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014657A MX2014014657A (es) | 2012-06-01 | 2013-05-31 | Heterociclos bicíclicos capaces de modular las respuestas de los linfocitos t, y métodos de uso de los mismos. |
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| Country | Link |
|---|---|
| US (2) | US20150126553A1 (enExample) |
| EP (1) | EP2861563B1 (enExample) |
| JP (1) | JP2015521195A (enExample) |
| KR (1) | KR20150016377A (enExample) |
| CN (1) | CN104619687A (enExample) |
| AU (1) | AU2013269550A1 (enExample) |
| BR (1) | BR112014030039A2 (enExample) |
| CA (1) | CA2874919A1 (enExample) |
| IN (1) | IN2014DN10214A (enExample) |
| MX (1) | MX2014014657A (enExample) |
| WO (1) | WO2013178815A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
| EA020856B1 (ru) | 2009-02-16 | 2015-02-27 | Джулиани Интернэшнл Лимитед | Способы лечения патологических состояний, связанных с волосами |
| JP6301844B2 (ja) | 2012-02-09 | 2018-03-28 | ノグラ ファーマ リミテッド | 線維症の処置方法 |
| EP2844242A1 (en) | 2012-04-18 | 2015-03-11 | Nogra Pharma Limited | Methods of treating lactose intolerance |
| US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| WO2017123826A1 (en) | 2016-01-14 | 2017-07-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| WO2019191327A1 (en) * | 2018-03-27 | 2019-10-03 | Board Of Regents, The University Of Texas System | Ox2r compounds |
| EP3921299B1 (en) | 2019-02-08 | 2024-11-20 | Nogra Pharma Limited | Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
| CR20220565A (es) * | 2020-05-06 | 2023-01-13 | Merck Sharp & Dohme Llc | Inhibidores de il4i1 y métodos de uso |
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| SU1069385A1 (ru) * | 1982-05-07 | 1990-11-15 | Научно-исследовательский институт фармакологии АМН СССР | Бромид 2-амино-3-(1-адамантилкарбонилметил)-1-( @ -пиперидино-этил)-бензимидазоли , обладающий способностью угнетать иммунитет |
| US7868028B2 (en) * | 2002-06-17 | 2011-01-11 | Fred Drasner | Guanidine compounds as anesthetics and for treatment of nervous system disorders |
| EP1861377B1 (en) * | 2005-03-15 | 2010-12-29 | Pfizer, Inc. | Benzimidazolone derivatives as cb2 receptor ligands |
| EP1926734A1 (en) * | 2005-08-22 | 2008-06-04 | Amgen Inc. | Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators |
| CA2637674A1 (en) * | 2006-01-19 | 2007-07-26 | Abbott Laboratories | 2-imino-benzimidazoles |
| WO2008036244A1 (en) * | 2006-09-18 | 2008-03-27 | The Burham Institute For Medical Research | Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands |
| EA018185B1 (ru) * | 2008-03-07 | 2013-06-28 | Ацьенде Кимике Рьюните Анджелини Франческо A.К.P.A.Ф. С.П.А. | Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1 или cx3cr1 |
| MX2010009625A (es) * | 2008-03-07 | 2010-09-28 | Acraf | Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40. |
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2013
- 2013-05-31 BR BR112014030039A patent/BR112014030039A2/pt not_active IP Right Cessation
- 2013-05-31 AU AU2013269550A patent/AU2013269550A1/en not_active Abandoned
- 2013-05-31 IN IN10214DEN2014 patent/IN2014DN10214A/en unknown
- 2013-05-31 MX MX2014014657A patent/MX2014014657A/es unknown
- 2013-05-31 WO PCT/EP2013/061328 patent/WO2013178815A1/en not_active Ceased
- 2013-05-31 US US14/404,838 patent/US20150126553A1/en not_active Abandoned
- 2013-05-31 CA CA 2874919 patent/CA2874919A1/en not_active Abandoned
- 2013-05-31 EP EP13726005.5A patent/EP2861563B1/en not_active Not-in-force
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- 2013-05-31 JP JP2015514534A patent/JP2015521195A/ja active Pending
- 2013-05-31 KR KR20147036702A patent/KR20150016377A/ko not_active Withdrawn
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2016
- 2016-12-14 US US15/378,672 patent/US20170183313A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2874919A1 (en) | 2013-12-05 |
| KR20150016377A (ko) | 2015-02-11 |
| BR112014030039A2 (pt) | 2017-06-27 |
| US20150126553A1 (en) | 2015-05-07 |
| WO2013178815A1 (en) | 2013-12-05 |
| CN104619687A (zh) | 2015-05-13 |
| JP2015521195A (ja) | 2015-07-27 |
| AU2013269550A1 (en) | 2014-12-18 |
| EP2861563B1 (en) | 2017-07-12 |
| US20170183313A1 (en) | 2017-06-29 |
| IN2014DN10214A (enExample) | 2015-08-07 |
| EP2861563A1 (en) | 2015-04-22 |
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