MX2014006731A - Anticuerpos para el receptor del factor de crecimiento epidermico 3 (her3) dirigidos al dominio iii y al dominio iv del her3. - Google Patents
Anticuerpos para el receptor del factor de crecimiento epidermico 3 (her3) dirigidos al dominio iii y al dominio iv del her3.Info
- Publication number
- MX2014006731A MX2014006731A MX2014006731A MX2014006731A MX2014006731A MX 2014006731 A MX2014006731 A MX 2014006731A MX 2014006731 A MX2014006731 A MX 2014006731A MX 2014006731 A MX2014006731 A MX 2014006731A MX 2014006731 A MX2014006731 A MX 2014006731A
- Authority
- MX
- Mexico
- Prior art keywords
- her3
- antibody
- fragment
- ligand
- amino acid
- Prior art date
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Classifications
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566912P | 2011-12-05 | 2011-12-05 | |
| PCT/IB2012/056956 WO2013084151A2 (en) | 2011-12-05 | 2012-12-04 | Antibodies for epidermal growth factor receptor 3 (her3) directed to domain iii and domain iv of her3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014006731A true MX2014006731A (es) | 2015-06-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014006731A MX2014006731A (es) | 2011-12-05 | 2012-12-04 | Anticuerpos para el receptor del factor de crecimiento epidermico 3 (her3) dirigidos al dominio iii y al dominio iv del her3. |
Country Status (16)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015223566B2 (en) | 2014-02-28 | 2020-10-08 | Merus N.V. | Antibodies that bind EGFR and ErbB3 |
| DK3110849T3 (da) * | 2014-02-28 | 2020-11-23 | Merus Nv | Antistof, der binder erbb-2 og erbb-3 |
| CN107257691B (zh) | 2014-07-16 | 2021-09-21 | 达娜-法勃肿瘤研究所公司 | 低级别浆液性卵巢癌中的her3抑制 |
| CN104530237B (zh) * | 2014-12-31 | 2017-09-05 | 百泰生物药业有限公司 | 抗Her1的治疗性抗体 |
| HRP20210483T1 (hr) | 2015-10-23 | 2021-07-09 | Merus N.V. | Vezujuće molekule koje inhibiraju rast raka |
| JP6729926B2 (ja) * | 2016-05-12 | 2020-07-29 | 国立大学法人神戸大学 | ＥｒｂＢ３活性化に伴うシグナルの伝達抑制物質及びそのスクリーニング方法 |
| AU2017327769B2 (en) * | 2016-09-15 | 2023-12-21 | Universität Stuttgart | Antigen binding protein against HER3 |
| KR101923641B1 (ko) * | 2016-11-25 | 2018-11-29 | 재단법인 목암생명과학연구소 | 항her3 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR20190140945A (ko) | 2017-03-31 | 2019-12-20 | 메뤼스 엔.페. | NRG1 융합 유전자를 가지는 세포를 치료하기 위한 ErbB-2 및 ErbB-3 결합 이중특이적 항체 |
| EP3625264B9 (en) | 2017-05-17 | 2023-10-25 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| EP3665198B9 (en) | 2017-08-09 | 2025-05-21 | Merus N.V. | Antibodies that bind egfr and cmet |
Family Cites Families (7)
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|---|---|---|---|---|
| AR056857A1 (es) * | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| EP2425009A4 (en) * | 2009-04-29 | 2013-01-23 | Trellis Bioscience Llc | IMMUNOREACTIVE ENHANCED ANTIBODIES WITH HEREGULINE COUPLE HER3 |
| BR112012012160B1 (pt) * | 2009-11-13 | 2022-04-26 | Amgen, Inc. | Material e métodos para tratar ou prevenir doenças associadas ao her-3 |
| BR112012025730B1 (pt) * | 2010-04-09 | 2020-12-08 | Aveo Pharmaceuticals, Inc | anticorpo isolado que se liga ao erbb3 humano, seus usos, seu processo de produção e vetor de expressão |
| TW201302793A (zh) * | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| NO2707391T3 (enrdf_load_html_response) * | 2011-05-13 | 2018-04-07 | ||
| CA2842860A1 (en) * | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies, Llc | Sur-binding proteins |
-
2012
- 2012-12-04 KR KR1020147018336A patent/KR20140099315A/ko not_active Withdrawn
- 2012-12-04 CA CA2857939A patent/CA2857939A1/en not_active Abandoned
- 2012-12-04 JP JP2014545420A patent/JP2015500830A/ja active Pending
- 2012-12-04 WO PCT/IB2012/056956 patent/WO2013084151A2/en active Application Filing
- 2012-12-04 EA EA201491120A patent/EA201491120A1/ru unknown
- 2012-12-04 SG SG11201402784WA patent/SG11201402784WA/en unknown
- 2012-12-04 EP EP12816130.4A patent/EP2788381A2/en not_active Withdrawn
- 2012-12-04 IN IN4374CHN2014 patent/IN2014CN04374A/en unknown
- 2012-12-04 UY UY0001034488A patent/UY34488A/es not_active Application Discontinuation
- 2012-12-04 TW TW101145508A patent/TW201331225A/zh unknown
- 2012-12-04 CN CN201280068966.8A patent/CN104093742A/zh active Pending
- 2012-12-04 BR BR112014013495A patent/BR112014013495A8/pt not_active Application Discontinuation
- 2012-12-04 AU AU2012349739A patent/AU2012349739A1/en not_active Abandoned
- 2012-12-04 MX MX2014006731A patent/MX2014006731A/es unknown
- 2012-12-05 AR ARP120104559A patent/AR089085A1/es unknown
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2014
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| IN2014CN04374A (enrdf_load_html_response) | 2015-09-04 |
| BR112014013495A2 (pt) | 2017-06-13 |
| UY34488A (es) | 2013-07-31 |
| AR089085A1 (es) | 2014-07-30 |
| AU2012349739A1 (en) | 2014-06-26 |
| WO2013084151A2 (en) | 2013-06-13 |
| EA201491120A1 (ru) | 2015-07-30 |
| CA2857939A1 (en) | 2013-06-13 |
| TW201331225A (zh) | 2013-08-01 |
| KR20140099315A (ko) | 2014-08-11 |
| EP2788381A2 (en) | 2014-10-15 |
| WO2013084151A3 (en) | 2014-01-03 |
| JP2015500830A (ja) | 2015-01-08 |
| BR112014013495A8 (pt) | 2017-06-13 |
| IL232950A0 (en) | 2014-07-31 |
| CN104093742A (zh) | 2014-10-08 |
| SG11201402784WA (en) | 2014-06-27 |
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