MX2013008714A - Metodo para producir compuesto di (arilamino) arilo y producto intermedio sintetico del mismo. - Google Patents

Metodo para producir compuesto di (arilamino) arilo y producto intermedio sintetico del mismo.

Info

Publication number
MX2013008714A
MX2013008714A MX2013008714A MX2013008714A MX2013008714A MX 2013008714 A MX2013008714 A MX 2013008714A MX 2013008714 A MX2013008714 A MX 2013008714A MX 2013008714 A MX2013008714 A MX 2013008714A MX 2013008714 A MX2013008714 A MX 2013008714A
Authority
MX
Mexico
Prior art keywords
arylamino
producing
aryl compound
synthetic intermediate
useful
Prior art date
Application number
MX2013008714A
Other languages
English (en)
Inventor
Kazuyoshi Obitsu
Yutaka Kondoh
Kazuhiro Takeguchi
Ryoki Orii
Takahiro Akiba
Koji Kobayashi
Shun Hirasawa
Yuji Takahama
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2013008714A publication Critical patent/MX2013008714A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se proporciona un método para producir un compuesto di(arilamino)arilo que tiene actividad inhibidora superior contra las actividades de quinasa de proteína de fusión de EML4-ALK y la proteína EGFR mutante y es útil como un ingrediente activo en composiciones farmacéuticas para el tratamiento del cáncer. El método de producción no incluye etapa de purificación alguna usando cromatografía en columna de gel de sílice o etapa que posiblemente produce un éster de mesilato mutagénico como un subproducto, mejora en gran medida el rendimiento global y es de alto rendimiento y de bajo costo y conveniente para la producción industrial de productos farmacéuticos. También se proporciona un producto intermedio sintético que es útil en el método de producción.
MX2013008714A 2011-01-28 2012-01-27 Metodo para producir compuesto di (arilamino) arilo y producto intermedio sintetico del mismo. MX2013008714A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011016110A JP2012153674A (ja) 2011-01-28 2011-01-28 ジ（アリールアミノ）アリール化合物の製造方法及びその合成中間体
PCT/JP2012/051876 WO2012102393A1 (ja) 2011-01-28 2012-01-27 ジ(アリールアミノ)アリール化合物の製造方法及びその合成中間体

Publications (1)

Publication Number Publication Date
MX2013008714A true MX2013008714A (es) 2013-08-29

Family

ID=46580956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008714A MX2013008714A (es) 2011-01-28 2012-01-27 Metodo para producir compuesto di (arilamino) arilo y producto intermedio sintetico del mismo.

Country Status (8)

Country Link
US (1) US20130338358A1 (es)
EP (1) EP2669281A4 (es)
JP (1) JP2012153674A (es)
KR (1) KR20140027921A (es)
CN (1) CN103339124A (es)
CA (1) CA2825925A1 (es)
MX (1) MX2013008714A (es)
WO (1) WO2012102393A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105037389B (zh) * 2015-06-09 2017-09-05 丹诺医药(苏州）有限公司 一种利福霉素‑硝基咪唑偶联分子的制备方法
CN113024454B (zh) * 2021-03-25 2022-09-09 浙江工业大学 一种布格替尼中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2306671T3 (es) * 1999-10-07 2008-11-16 Amgen Inc. Inhibidores de triazina quinasa.
PT1224174E (pt) * 1999-10-15 2004-01-30 Hoffmann La Roche Derivados de benzodiazepina como antagonistas do receptor metabotropico do glutamato
PT1479397E (pt) * 2002-02-05 2011-09-01 Astellas Pharma Inc Derivados de 2,4,6-triamino-1,3,5-triazina
CA2492194A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites
CA2533320A1 (en) 2003-08-15 2006-02-24 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
TWI389893B (zh) * 2007-07-06 2013-03-21 Astellas Pharma Inc 二（芳胺基）芳基化合物
US20130059855A1 (en) 2010-05-18 2013-03-07 Astellas Pharma Inc. Crystal of di(arylamino)aryl compound

Also Published As

Publication number Publication date
EP2669281A4 (en) 2014-01-29
US20130338358A1 (en) 2013-12-19
JP2012153674A (ja) 2012-08-16
KR20140027921A (ko) 2014-03-07
CA2825925A1 (en) 2012-08-02
EP2669281A1 (en) 2013-12-04
WO2012102393A1 (ja) 2012-08-02
CN103339124A (zh) 2013-10-02

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