MX2013005821A - Benzoxazepinas como inhibidores de fosfatidilinositol/objetivo de rapamicina en mamiferos (p13k/mtor) y metodos de uso y fabricacion. - Google Patents

Benzoxazepinas como inhibidores de fosfatidilinositol/objetivo de rapamicina en mamiferos (p13k/mtor) y metodos de uso y fabricacion.

Info

Publication number
MX2013005821A
MX2013005821A MX2013005821A MX2013005821A MX2013005821A MX 2013005821 A MX2013005821 A MX 2013005821A MX 2013005821 A MX2013005821 A MX 2013005821A MX 2013005821 A MX2013005821 A MX 2013005821A MX 2013005821 A MX2013005821 A MX 2013005821A
Authority
MX
Mexico
Prior art keywords
inhibitors
methods
benzoxazepines
tor
asn
Prior art date
Application number
MX2013005821A
Other languages
English (en)
Inventor
Kenneth Rice
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MX2013005821A publication Critical patent/MX2013005821A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se dirige a los inhibidores de mTOR y sales farmacéuticamente aceptables o solvatos de éstos así como los métodos de usarlos. Los inhibidores son generalmente de la Fórmula estructural I y sales farmacéuticamente aceptables de estos, en donde las variables son como se definen en la presente descripción. (Fórmula).
MX2013005821A 2010-11-24 2011-11-23 Benzoxazepinas como inhibidores de fosfatidilinositol/objetivo de rapamicina en mamiferos (p13k/mtor) y metodos de uso y fabricacion. MX2013005821A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41716510P 2010-11-24 2010-11-24
PCT/US2011/062025 WO2012071501A1 (en) 2010-11-24 2011-11-23 Benzoxazepines asn inhibitors of p13k/m tor and methods of their use and manufacture

Publications (1)

Publication Number Publication Date
MX2013005821A true MX2013005821A (es) 2013-08-27

Family

ID=45099217

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005821A MX2013005821A (es) 2010-11-24 2011-11-23 Benzoxazepinas como inhibidores de fosfatidilinositol/objetivo de rapamicina en mamiferos (p13k/mtor) y metodos de uso y fabricacion.

Country Status (12)

Country Link
US (1) US20140073628A1 (es)
EP (1) EP2643315A1 (es)
JP (1) JP2013544826A (es)
KR (1) KR20130119951A (es)
CN (1) CN103384667A (es)
AU (1) AU2011332849A1 (es)
BR (1) BR112013012950A2 (es)
CA (1) CA2818898A1 (es)
EA (1) EA201390757A1 (es)
MX (1) MX2013005821A (es)
WO (1) WO2012071501A1 (es)
ZA (1) ZA201303855B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5792819B2 (ja) 2010-09-14 2015-10-14 エクセリクシス， インク． Ｐｉ３ｋ−デルタの阻害剤ならびにそれらの使用法および製造法
KR20140096083A (ko) 2011-11-01 2014-08-04 엑셀리시스, 인코포레이티드 림프증식성 악성종양의 치료를 위한 포스파티딜이노시톨 3-키나아제 저해제로서 ｎ­（3­｛［（3­｛［2­클로로­5­（메톡시）페닐］아미노｝퀴녹살린­2­일）아미노］설포닐｝페닐）­2­메틸알라닌아미드
CN102786512A (zh) * 2012-05-31 2012-11-21 中国人民解放军军事医学科学院毒物药物研究所 N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用
WO2019075386A1 (en) * 2017-10-13 2019-04-18 The Regents Of The University Of California MODULATORS OF MTORC1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090233926A1 (en) * 2006-09-14 2009-09-17 Astrazeneca 2-benzimidazolyl-6-morpholino-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
EP2432779A1 (en) * 2009-05-22 2012-03-28 Exelixis, Inc. Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases
WO2010135568A1 (en) * 2009-05-22 2010-11-25 Exelixis, Inc. Benzoxazepines as inhibitors of mtor and their use to treat cancer

Also Published As

Publication number Publication date
BR112013012950A2 (pt) 2017-08-29
EA201390757A1 (ru) 2013-11-29
WO2012071501A1 (en) 2012-05-31
US20140073628A1 (en) 2014-03-13
JP2013544826A (ja) 2013-12-19
AU2011332849A1 (en) 2013-06-20
ZA201303855B (en) 2014-01-29
CA2818898A1 (en) 2012-05-31
EP2643315A1 (en) 2013-10-02
KR20130119951A (ko) 2013-11-01
CN103384667A (zh) 2013-11-06

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