MX2012014422A - Derivados de trisacaridos, y su uso como adyuvantes. - Google Patents

Derivados de trisacaridos, y su uso como adyuvantes.

Info

Publication number
MX2012014422A
MX2012014422A MX2012014422A MX2012014422A MX2012014422A MX 2012014422 A MX2012014422 A MX 2012014422A MX 2012014422 A MX2012014422 A MX 2012014422A MX 2012014422 A MX2012014422 A MX 2012014422A MX 2012014422 A MX2012014422 A MX 2012014422A
Authority
MX
Mexico
Prior art keywords
trisaccharide
adjuvants
derivates
trisaccharide derivates
trisaccharides
Prior art date
Application number
MX2012014422A
Other languages
English (en)
Other versions
MX342946B (es
Inventor
Robert Patrick Hof
Johannes Gernardus Mathias Marie Van Bree
Everardus Joannes Peter Maria Schenkelaars
Jouwert Anne Turkstra
Maria Aldegonda Jacoba Kriek
Wilhelmus Martinus Maria Schaaper
Original Assignee
Immunovo B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunovo B V filed Critical Immunovo B V
Publication of MX2012014422A publication Critical patent/MX2012014422A/es
Publication of MX342946B publication Critical patent/MX342946B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere al uso de derivados de trisacáridos que comprenden un núcleo sustituido de trisacáridos, cuyo núcleo de trisacáridos está completamente sustituido con grupos éster de ácido graso, y opcionalmente uno o más grupos aniónicos como adyuvantes para los derivados de trisacárido como tales, a un método para preparar tales trisacáridos, a trisacáridos obtenidos con tal método, a composiciones adyuvantes que comprenden tales derivados de trisacáridos y a una vacuna o kit que comprende tales composiciones adyuvantes.
MX2012014422A 2010-06-11 2011-06-03 Derivados de trisacaridos, y su uso como adyuvantes. MX342946B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10165707A EP2397484A1 (en) 2010-06-11 2010-06-11 Trisaccharide derivates, and their use as adjuvants
PCT/NL2011/050393 WO2011155822A1 (en) 2010-06-11 2011-06-03 Trisaccharide derivates, and their use as adjuvants

Publications (2)

Publication Number Publication Date
MX2012014422A true MX2012014422A (es) 2013-08-27
MX342946B MX342946B (es) 2016-10-18

Family

ID=43734127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014422A MX342946B (es) 2010-06-11 2011-06-03 Derivados de trisacaridos, y su uso como adyuvantes.

Country Status (24)

Country Link
US (2) US9327020B2 (es)
EP (3) EP2397484A1 (es)
JP (2) JP6004586B2 (es)
KR (1) KR101929973B1 (es)
CN (1) CN103154013B (es)
AU (1) AU2011262606B2 (es)
BR (1) BR112012031440A2 (es)
CA (1) CA2802023C (es)
CY (1) CY1119704T1 (es)
DK (1) DK2580226T3 (es)
ES (1) ES2654156T3 (es)
HR (1) HRP20171947T1 (es)
HU (1) HUE035187T2 (es)
IL (1) IL223570A (es)
LT (1) LT2580226T (es)
MX (1) MX342946B (es)
NO (1) NO2580226T3 (es)
PL (1) PL2580226T3 (es)
PT (1) PT2580226T (es)
RS (1) RS56690B1 (es)
RU (1) RU2595717C2 (es)
SI (1) SI2580226T1 (es)
WO (1) WO2011155822A1 (es)
ZA (1) ZA201209395B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2397484A1 (en) * 2010-06-11 2011-12-21 Immunovo B.V. Trisaccharide derivates, and their use as adjuvants
ES2759542T3 (es) * 2014-07-24 2020-05-11 Litevax B V Adyuvantes

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232150A (en) * 1979-07-09 1980-11-04 American Cyanamid Company Oligosaccharide precursors to substituted O-α-D and O-β-D-multigalactopyranosyl and glucopyranosyl 1→4 and 1→6 galactopyranosyl 1→6α-D-glucopyranoses
GB8703128D0 (en) * 1987-02-11 1987-03-18 Donmarn Ltd Anti-scaling compounds
US5543505A (en) * 1993-03-15 1996-08-06 Sloan-Kettering Institute For Cancer Research Synthetic compounds which bind to H. pylori, and uses thereof
US6303120B1 (en) * 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5708163A (en) * 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
DE69531992T2 (de) * 1994-08-04 2004-07-22 Elan Drug Delivery Ltd., Ruddington Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
BE1008978A5 (fr) 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US6517860B1 (en) * 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
US6352722B1 (en) * 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
JP3041799B1 (ja) * 1998-09-29 2000-05-15 株式会社微生物化学研究所 新規なアジュバント及びそれを用いたワクチン
EP1104767A1 (en) 1999-11-30 2001-06-06 Stichting Dienst Landbouwkundig Onderzoek Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups
GB0124710D0 (en) * 2001-10-15 2001-12-05 Quadrant Healthcare Uk Ltd Therapeutic composition
ATE409457T1 (de) * 2005-12-01 2008-10-15 Wella Ag Verwendung von di- oder oligosaccharidepolyestern in haarstylingprodukten
US9045516B2 (en) * 2007-04-16 2015-06-02 Suri Saranathan Iyer Synthetic ligands for the differentiation of closely related toxins and pathogens
WO2009140683A1 (en) * 2008-05-16 2009-11-19 Research Foundation Of The City University Of New York Living copolymer protein/peptide hybrids for biomedical applications
SG2014006985A (en) * 2009-02-02 2014-04-28 Otsuka Pharma Co Ltd Low-molecular polysulfated hyaluronic acid derivative and medicine containing same
EP2397484A1 (en) * 2010-06-11 2011-12-21 Immunovo B.V. Trisaccharide derivates, and their use as adjuvants

Also Published As

Publication number Publication date
HRP20171947T1 (hr) 2018-02-23
US20130273082A1 (en) 2013-10-17
EP2580226A1 (en) 2013-04-17
EP3312188A1 (en) 2018-04-25
JP2016216471A (ja) 2016-12-22
KR20130056273A (ko) 2013-05-29
ES2654156T3 (es) 2018-02-12
EP2580226B1 (en) 2017-11-29
IL223570A (en) 2017-03-30
RU2013100945A (ru) 2014-07-20
CY1119704T1 (el) 2018-06-27
BR112012031440A2 (pt) 2017-04-18
JP2013528211A (ja) 2013-07-08
CA2802023C (en) 2020-07-14
SI2580226T1 (en) 2018-04-30
ZA201209395B (en) 2014-05-28
CN103154013B (zh) 2017-03-15
HUE035187T2 (hu) 2018-05-02
RU2595717C2 (ru) 2016-08-27
EP2397484A1 (en) 2011-12-21
RS56690B1 (sr) 2018-03-30
DK2580226T3 (en) 2018-01-08
CA2802023A1 (en) 2011-12-15
PT2580226T (pt) 2018-01-05
AU2011262606B2 (en) 2016-10-27
US9327020B2 (en) 2016-05-03
PL2580226T3 (pl) 2018-05-30
JP6004586B2 (ja) 2016-10-12
LT2580226T (lt) 2018-02-26
CN103154013A (zh) 2013-06-12
MX342946B (es) 2016-10-18
NO2580226T3 (es) 2018-04-28
US20170057987A1 (en) 2017-03-02
KR101929973B1 (ko) 2018-12-18
AU2011262606A1 (en) 2013-01-10
WO2011155822A1 (en) 2011-12-15

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