MX2012014284A - Metodos y kits para diagnosticar afecciones relacionadas con hipoxia. - Google Patents

Metodos y kits para diagnosticar afecciones relacionadas con hipoxia.

Info

Publication number
MX2012014284A
MX2012014284A MX2012014284A MX2012014284A MX2012014284A MX 2012014284 A MX2012014284 A MX 2012014284A MX 2012014284 A MX2012014284 A MX 2012014284A MX 2012014284 A MX2012014284 A MX 2012014284A MX 2012014284 A MX2012014284 A MX 2012014284A
Authority
MX
Mexico
Prior art keywords
hypoxia
kits
methods
condition associated
conditions related
Prior art date
Application number
MX2012014284A
Other languages
English (en)
Inventor
Osnat Ashur-Fabian
Original Assignee
Osnat Ashur-Fabian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osnat Ashur-Fabian filed Critical Osnat Ashur-Fabian
Publication of MX2012014284A publication Critical patent/MX2012014284A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

La presente invención proporciona un método para detectar una afección asociada a la hipoxia en un sujeto, un método para determinar la gravedad de una afección asociada a la hipoxia, un método para la eficacia de un tratamiento terapéutico de una afección asociada a la hipoxia y un método para seleccionar a un sujeto que parece una afección asociada a la hipoxia para recibir tratamiento terapéutico, donde los métodos de la invención están basados en medir el nivel de un ácido ribonucleico (ARN) libre de células de un gen inducible por p53 en el sujeto. La presente invención también se refiere a kits para llevar a cabo los métodos de la invención.
MX2012014284A 2010-06-07 2011-06-06 Metodos y kits para diagnosticar afecciones relacionadas con hipoxia. MX2012014284A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35201910P 2010-06-07 2010-06-07
PCT/IL2011/000444 WO2011154940A1 (en) 2010-06-07 2011-06-06 Methods and kits for diagnosing conditions related to hypoxia

Publications (1)

Publication Number Publication Date
MX2012014284A true MX2012014284A (es) 2013-04-29

Family

ID=44628244

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014284A MX2012014284A (es) 2010-06-07 2011-06-06 Metodos y kits para diagnosticar afecciones relacionadas con hipoxia.

Country Status (10)

Country Link
US (1) US20130316351A1 (es)
EP (1) EP2576829A1 (es)
JP (1) JP2013529092A (es)
KR (1) KR20130123357A (es)
CN (1) CN102933723A (es)
AU (1) AU2011263306A1 (es)
BR (1) BR112012031045A2 (es)
CA (1) CA2801849A1 (es)
MX (1) MX2012014284A (es)
WO (1) WO2011154940A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150159199A1 (en) * 2012-03-16 2015-06-11 Innomart Pte Ltd Methods and Systems for the Detection of Methicillin Resistant Staphylococcus Aureus
CN102676500A (zh) * 2012-03-26 2012-09-19 南京大学医学院附属鼓楼医院 微量游离mRNA提取和富集方法
CA3117788A1 (en) * 2013-02-28 2014-09-04 The Chinese University Of Hong Kong Maternal plasma transcriptome analysis by massively parallel rna sequencing
US11773447B2 (en) * 2014-11-14 2023-10-03 Nanthealth Labs, Inc. Use of circulating cell-free RNA for diagnosis and/or monitoring cancer
JP7445997B2 (ja) * 2020-06-08 2024-03-08 国立大学法人東海国立大学機構 マイクロｒｎａの慢性期心機能改善治療への利用
KR102398534B1 (ko) * 2020-11-05 2022-05-13 한림대학교 산학협력단 지연성 뇌허혈 진단을 위한 bnip3l 바이오마커
CN112717134B (zh) * 2021-01-15 2022-05-20 山东大学齐鲁医院 一种用于儿童情感障碍的基因药物
CN116732039B (zh) * 2023-08-03 2023-11-14 呈诺再生医学科技(北京)有限公司 一种促进rna序列在细胞内直接环化翻译的序列组合及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
CA2250118C (en) * 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
US20070009934A1 (en) * 1997-03-14 2007-01-11 Kopreski Michael S Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US7144999B2 (en) * 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
CA2513292C (en) * 2003-01-17 2016-04-05 The Chinese University Of Hong Kong Circulating mrna as diagnostic markers for pregnancy-related disorders
US7888030B2 (en) * 2008-08-21 2011-02-15 King's College London Biomarkers
WO2010079118A1 (en) * 2009-01-07 2010-07-15 Michael Roth-Chiarello Use of rna obtained from proteolipid complexes circulating in blood for diagnosis and treatment of tumors

Also Published As

Publication number Publication date
JP2013529092A (ja) 2013-07-18
CN102933723A (zh) 2013-02-13
CA2801849A1 (en) 2011-12-15
US20130316351A1 (en) 2013-11-28
BR112012031045A2 (pt) 2017-06-20
KR20130123357A (ko) 2013-11-12
AU2011263306A1 (en) 2013-01-10
WO2011154940A1 (en) 2011-12-15
EP2576829A1 (en) 2013-04-10

Similar Documents

Publication Publication Date Title
MX2012014284A (es) Metodos y kits para diagnosticar afecciones relacionadas con hipoxia.
WO2009151628A3 (en) Monitoring tcr-b to determine hiv therapy and disease progression
MX341840B (es) Biomarcadores de microarn indicativos de la enfermedad de alzheimer.
WO2012075506A3 (en) Methods for predicting and treating infection-induced illnesses and predicting the severity of infection-induced illnesses
MX2013000916A (es) Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales.
WO2012167142A3 (en) Enzyme quantification
MX2014006118A (es) Deteccion de analitos.
WO2010004591A3 (en) Genetic variants for breast cancer risk assessment
IN2014KN02647A (es)
WO2013009655A3 (en) Uses of labeled hsp90 inhibitors
GB201009641D0 (en) Methods of monitoring conditions by sequence analysis
WO2012097081A3 (en) Protein detection method
BR112013001752A2 (pt) método de detectar doenças ou condições usando células fagocídicas
WO2012096545A3 (ko) 췌장암 암줄기세포 특성을 이용한 췌장암 신규 바이오마커 및 그의 용도
WO2011047033A3 (en) Biomarker for identification of melanoma tumor cells
WO2011015944A3 (en) Use of free dna as an early predictor of severity in acute pancreatitis
PH12017500798A1 (en) Pna probes, kits and methods for detecting human papillomavirus genotypes of human papillomavirus
EA201291228A1 (ru) Биомаркер для детекции высокогорной адаптации и высокогорного отека легких
WO2013159872A8 (en) Biomarkers for the diagnosis, prognosis, assessment and therapy stratification of syncope
WO2009149319A3 (en) Gene expression profiles associated with asthma exacerbation attacks
GB2542576A (en) Method and kit of detecting the absence of micro-oranisms
WO2011103330A3 (en) Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury
WO2012145516A3 (en) Methods and kits for quantitative determination of total organic acid content in a coolant
WO2012089753A3 (en) Complex sets of mirnas as non-invasive biomarkers for glioblastoma
MX2009001070A (es) Uso de proteina con actividad inhibidora de melanoma (mia) como un indicador temprano para la respuesta terapeutica en melanoma.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal