MX2012006691A - Nuevos conjugados y composiciones para inmunoterapia y tratamiento antitumoral. - Google Patents
Nuevos conjugados y composiciones para inmunoterapia y tratamiento antitumoral.Info
- Publication number
- MX2012006691A MX2012006691A MX2012006691A MX2012006691A MX2012006691A MX 2012006691 A MX2012006691 A MX 2012006691A MX 2012006691 A MX2012006691 A MX 2012006691A MX 2012006691 A MX2012006691 A MX 2012006691A MX 2012006691 A MX2012006691 A MX 2012006691A
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- functionally equivalent
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- fusion protein
- cells
- polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Landscapes
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| CA2824515C (en) | 2011-01-18 | 2022-09-13 | Bioniz, Llc | Compositions and methods for modulating gamma-c-cytokine activity |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| JP2016518361A (ja) * | 2013-04-19 | 2016-06-23 | シーチューヌ ファルマＣｙｔｕｎｅ Ｐｈａｒｍａ | 血管漏出症候群の発生を抑制するサイトカイン治療 |
| WO2015054701A2 (en) * | 2013-10-13 | 2015-04-16 | Nova Southeastern University | Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders, identification of a natural killer cell population as a potential therapeutic target for gulf war illness & myalgic encephalomyelitis/chronic fatigue syndrome, and modulation of natural killer cell function by stimulation with interleukin 15 |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| LT3094351T (lt) * | 2014-01-15 | 2022-04-11 | Kadmon Corporation, Llc | Imunitetą moduliuojantys agentai |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| WO2015164107A1 (en) | 2014-04-23 | 2015-10-29 | Emory University | Compositions of gm-csf and interleukin fusions for immune modulation and uses related thereto |
| US12577323B2 (en) | 2015-06-10 | 2026-03-17 | Emory University | Compositions and conjugates comprising an interleukin and polypeptides that specifically bind TGF-beta |
| CN106317225A (zh) * | 2015-06-28 | 2017-01-11 | 复旦大学 | 具有靶向性长效白细胞介素22融合蛋白及其制备方法和用途 |
| EP3978512A1 (en) | 2015-10-09 | 2022-04-06 | Bioniz, LLC | Modulating gamma-c-cytokine activity |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| KR102707650B1 (ko) | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| JP7386161B2 (ja) * | 2017-12-19 | 2023-11-24 | ブレイズ バイオサイエンス， インコーポレイテッド | 腫瘍ホーミング及び細胞透過性ペプチド免疫抗がん剤複合体、ならびにそれらの使用方法 |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| BR112021021878A2 (pt) | 2019-05-03 | 2022-01-18 | Bioniz Llc | Modulação dos efeitos de sinalização da gama-c-citocina para tratamento da alopecia e distúrbios associados |
| US20250281583A1 (en) * | 2021-10-13 | 2025-09-11 | Modernatx, Inc. | Composition of mrna-encoded il15 fusion proteins and methods of use thereof |
| US20240043499A1 (en) * | 2022-08-07 | 2024-02-08 | Protean Bio, Inc. | Peptides for beta-cell survival and insulin production |
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| WO1987002061A1 (en) * | 1985-10-03 | 1987-04-09 | Biotechnology Research Partners, Ltd. | Novel lipoprotein-based drug-delivery systems |
| US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
| US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| WO1996027392A1 (en) | 1995-03-08 | 1996-09-12 | The Scripps Research Institute | Antigen presenting system and methods for activation of t-cells |
| US6787154B2 (en) | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| WO2002038609A2 (en) * | 2000-11-10 | 2002-05-16 | Proteopharma Aps | Apolipoprotein conjugates |
| AU2008201887B2 (en) * | 2000-11-10 | 2011-06-30 | F. Hoffmann-La Roche Ltd. | Apolipoprotein analogues |
| WO2005070400A1 (en) | 2004-01-15 | 2005-08-04 | Mount Sinai School Of Medicine | Methods and compositions for imaging |
| WO2006135436A2 (en) | 2004-10-22 | 2006-12-21 | University Of Florida Research Foundation, Inc. | Inhibition of gene expression and therapeutic uses thereof |
| US20060257361A1 (en) | 2005-04-12 | 2006-11-16 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Novel form of interleukin-15, Fc-IL-15, and methods of use |
| EP1969000A2 (en) | 2005-12-06 | 2008-09-17 | Centre National de la Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| CA2657277C (en) * | 2006-07-13 | 2015-11-24 | Upperton Limited | Process for preparing particles of proteinaceous material |
| KR100817024B1 (ko) | 2006-11-09 | 2008-03-26 | 재단법인 목암생명공학연구소 | 핵산 또는 약물을 간에 특이적으로 전달하는 복합체 및이를 포함하는 약학적 조성물 |
| EP2305309A2 (en) | 2008-06-13 | 2011-04-06 | Proyecto de Biomedicina Cima, S.L. | Conjugates for the administration of biologically active compounds |
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| RU2597989C2 (ru) | 2016-09-20 |
| CA2783876C (en) | 2018-04-03 |
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| EP2511294B1 (en) | 2014-02-26 |
| ES2463016T3 (es) | 2014-05-27 |
| RU2012129208A (ru) | 2014-01-20 |
| AU2010329805A1 (en) | 2012-07-05 |
| BR112012013868A2 (pt) | 2017-01-10 |
| EP2511294A2 (en) | 2012-10-17 |
| AU2010329805B2 (en) | 2016-07-14 |
| CA2783876A1 (en) | 2011-06-16 |
| BR112012013868A8 (pt) | 2017-12-26 |
| JP5784626B2 (ja) | 2015-09-24 |
| JP2013513377A (ja) | 2013-04-22 |
| US20120244118A1 (en) | 2012-09-27 |
| WO2011070214A2 (es) | 2011-06-16 |
| CN102753574A (zh) | 2012-10-24 |
| US8771664B2 (en) | 2014-07-08 |
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