MX2011011351A - Agentes de imagenologia molecular etiquetados, metodos para hacerlos y metodos de uso. - Google Patents

Agentes de imagenologia molecular etiquetados, metodos para hacerlos y metodos de uso.

Info

Publication number
MX2011011351A
MX2011011351A MX2011011351A MX2011011351A MX2011011351A MX 2011011351 A MX2011011351 A MX 2011011351A MX 2011011351 A MX2011011351 A MX 2011011351A MX 2011011351 A MX2011011351 A MX 2011011351A MX 2011011351 A MX2011011351 A MX 2011011351A
Authority
MX
Mexico
Prior art keywords
methods
imaging agents
making
molecular imaging
labeled
Prior art date
Application number
MX2011011351A
Other languages
English (en)
Other versions
MX336722B (es
Inventor
Rong Zhang
Faisal Ahmed Syud
Brian Duh-Lan Lee
Paul Schaffer
Jack Mathew Webster
Jennifer Huntington
Kande Kankanamalage Dayara Amarasinghe
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42790740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011011351(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Electric filed Critical Gen Electric
Publication of MX2011011351A publication Critical patent/MX2011011351A/es
Publication of MX336722B publication Critical patent/MX336722B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Agentes de imagenología que comprenden substratos etiquetados del anticargador de cistina/glutamato de células, por lo cual los métodos de uso comprenden introducir los agentes etiquetados en células vía el anticargador de cistina/glutamato, los cuales son reducidos entonces a una cisteína etiquetada y subsecuentemente detectados en la célula.
MX2011011351A 2009-04-27 2010-04-27 Agentes de imagenologia molecular etiquetados, metodos para hacerlos y metodos de uso. MX336722B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/430,573 US8834839B2 (en) 2009-04-27 2009-04-27 Labeled molecular imaging agents, methods of making and methods of use
PCT/EP2010/055629 WO2010125068A2 (en) 2009-04-27 2010-04-27 Labeled molecular imaging agents, methods of making and methods of use

Publications (2)

Publication Number Publication Date
MX2011011351A true MX2011011351A (es) 2011-11-18
MX336722B MX336722B (es) 2016-01-28

Family

ID=42790740

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011351A MX336722B (es) 2009-04-27 2010-04-27 Agentes de imagenologia molecular etiquetados, metodos para hacerlos y metodos de uso.

Country Status (11)

Country Link
US (1) US8834839B2 (es)
EP (1) EP2424573B1 (es)
JP (1) JP5709841B2 (es)
KR (1) KR101686264B1 (es)
CN (1) CN102413844B (es)
AU (1) AU2010243678B2 (es)
BR (1) BRPI1015323A2 (es)
CA (1) CA2759000C (es)
MX (1) MX336722B (es)
RU (1) RU2523411C2 (es)
WO (1) WO2010125068A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520556A1 (en) 2011-05-03 2012-11-07 Bayer Pharma Aktiengesellschaft Radiolabeled amino acids for diagnostic imaging
CN103781471B (zh) 2011-09-08 2019-02-12 健康科学西部大学 癌症治疗中的靶向脂质体
US8784774B2 (en) * 2011-09-16 2014-07-22 General Electric Company Labeled molecular imaging agents and methods of use
WO2014183110A1 (en) * 2013-05-10 2014-11-13 The University Of Montana Methods for the detection of brain injury
US9468692B2 (en) 2014-01-23 2016-10-18 General Electric Company Labeled molecular imaging agents and methods of use
US9468693B2 (en) * 2014-01-23 2016-10-18 General Electric Company Labeled molecular imaging agents and methods of use
CN104629752B (zh) * 2015-01-28 2016-05-04 东南大学 一种识别凋亡细胞的荧光分子探针制备方法
RU2717308C1 (ru) * 2019-06-25 2020-03-20 Федеральное государственное бюджетное научное учреждение "Иркутский научный центр хирургии и травматологии" Флуоресцентный сенсор для детектирования лизосом in vitro

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171563A (en) 1988-09-30 1992-12-15 Neorx Corporation Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
CA2302360C (en) 1997-09-03 2005-11-15 Immunomedics, Inc. Fluorination of proteins and peptides for f-18 positron emission tomography
IL147812A0 (en) * 2001-03-16 2002-08-14 N S T Neurosurvival Technologi Method for targeting chemical compounds to cells and pharmaceutical compositions used therein
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7666979B2 (en) 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
GB0420344D0 (en) * 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds

Also Published As

Publication number Publication date
AU2010243678B2 (en) 2015-11-05
JP5709841B2 (ja) 2015-04-30
CA2759000A1 (en) 2010-11-04
CN102413844A (zh) 2012-04-11
BRPI1015323A2 (pt) 2020-10-06
WO2010125068A3 (en) 2011-01-20
WO2010125068A2 (en) 2010-11-04
EP2424573A2 (en) 2012-03-07
US8834839B2 (en) 2014-09-16
US20100272641A1 (en) 2010-10-28
KR20120015308A (ko) 2012-02-21
RU2523411C2 (ru) 2014-07-20
AU2010243678A1 (en) 2011-10-27
CN102413844B (zh) 2014-12-10
CA2759000C (en) 2017-08-08
KR101686264B1 (ko) 2016-12-13
EP2424573B1 (en) 2019-01-16
MX336722B (es) 2016-01-28
JP2012525328A (ja) 2012-10-22

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