MX2010013608A - Pirroles sustituidos y metodos de uso. - Google Patents
Pirroles sustituidos y metodos de uso.Info
- Publication number
- MX2010013608A MX2010013608A MX2010013608A MX2010013608A MX2010013608A MX 2010013608 A MX2010013608 A MX 2010013608A MX 2010013608 A MX2010013608 A MX 2010013608A MX 2010013608 A MX2010013608 A MX 2010013608A MX 2010013608 A MX2010013608 A MX 2010013608A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- useful
- compounds
- relates
- inhibitors
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003233 pyrroles Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101150006084 CHKB gene Proteins 0.000 abstract 1
- 102000006459 Checkpoint Kinase 1 Human genes 0.000 abstract 1
- 108010019244 Checkpoint Kinase 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012830 cancer therapeutic Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se relaciona con compuestos de pirrol sustituidos de Fórmula (I), que son útiles como inhibidores de la cinasa, de manera más específica, útiles como inhibidores del punto de control de la cinasa 1 (chk1), así como útiles como agentes terapéuticos para el cáncer. La invención también se relaciona con composiciones, de manera más específica, composiciones farmacéuticas que comprenden estos compuestos y métodos para utilizar los mismos para tratar varias formas de cáncer y trastornos hiperproliferativos, así como métodos para utilizar los compuestos para el diagnóstico in vitro, in situ e in vivo o el tratamiento de células de mamífero, o condiciones patológicas asociadas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6075208P | 2008-06-11 | 2008-06-11 | |
| US10461808P | 2008-10-10 | 2008-10-10 | |
| PCT/US2009/003493 WO2009151599A1 (en) | 2008-06-11 | 2009-06-10 | Substituted pyrroles and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010013608A true MX2010013608A (es) | 2011-03-29 |
Family
ID=41079719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010013608A MX2010013608A (es) | 2008-06-11 | 2009-06-10 | Pirroles sustituidos y metodos de uso. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8410279B2 (es) |
| EP (1) | EP2300457B1 (es) |
| JP (1) | JP5662931B2 (es) |
| KR (1) | KR20110015627A (es) |
| CN (1) | CN102119156B (es) |
| AU (1) | AU2009258125B2 (es) |
| BR (1) | BRPI0910015A2 (es) |
| CA (1) | CA2725755A1 (es) |
| ES (1) | ES2522628T3 (es) |
| IL (1) | IL209545A0 (es) |
| MX (1) | MX2010013608A (es) |
| WO (1) | WO2009151599A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029241A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| RU2006107782A (ru) * | 2003-08-15 | 2006-08-10 | Астразенека Аб (Se) | Замещенные тиофены и их применение |
| JP2007520471A (ja) * | 2003-12-22 | 2007-07-26 | イーライ リリー アンド カンパニー | Ｐｐａｒ受容体調節物質としての二環式誘導体 |
| BRPI0418351A (pt) * | 2004-01-05 | 2007-05-08 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo |
| AU2006205220B2 (en) * | 2005-01-10 | 2012-09-13 | Exelixis, Inc. | Heterocyclic carboxamide compounds as steroid nuclear receptors ligands |
-
2009
- 2009-06-10 CA CA2725755A patent/CA2725755A1/en not_active Abandoned
- 2009-06-10 AU AU2009258125A patent/AU2009258125B2/en not_active Ceased
- 2009-06-10 JP JP2011513499A patent/JP5662931B2/ja not_active Expired - Fee Related
- 2009-06-10 KR KR1020107027787A patent/KR20110015627A/ko not_active Application Discontinuation
- 2009-06-10 US US12/997,070 patent/US8410279B2/en not_active Expired - Fee Related
- 2009-06-10 EP EP09762895.2A patent/EP2300457B1/en active Active
- 2009-06-10 MX MX2010013608A patent/MX2010013608A/es active IP Right Grant
- 2009-06-10 BR BRPI0910015A patent/BRPI0910015A2/pt not_active IP Right Cessation
- 2009-06-10 CN CN200980131188.0A patent/CN102119156B/zh not_active Expired - Fee Related
- 2009-06-10 ES ES09762895.2T patent/ES2522628T3/es active Active
- 2009-06-10 WO PCT/US2009/003493 patent/WO2009151599A1/en active Application Filing
-
2010
- 2010-11-24 IL IL209545A patent/IL209545A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2300457A1 (en) | 2011-03-30 |
| EP2300457B1 (en) | 2014-08-20 |
| KR20110015627A (ko) | 2011-02-16 |
| US20110118320A1 (en) | 2011-05-19 |
| AU2009258125A2 (en) | 2011-02-10 |
| ES2522628T3 (es) | 2014-11-17 |
| JP2011522890A (ja) | 2011-08-04 |
| CA2725755A1 (en) | 2009-12-17 |
| AU2009258125B2 (en) | 2015-01-15 |
| IL209545A0 (en) | 2011-01-31 |
| JP5662931B2 (ja) | 2015-02-04 |
| US8410279B2 (en) | 2013-04-02 |
| WO2009151599A1 (en) | 2009-12-17 |
| CN102119156A (zh) | 2011-07-06 |
| CN102119156B (zh) | 2015-01-21 |
| BRPI0910015A2 (pt) | 2016-08-09 |
| AU2009258125A1 (en) | 2009-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |