MX2010003757A - Composiciones que comprenden multimeros optimizados de her1 y her3 y sus metodos de uso. - Google Patents

Composiciones que comprenden multimeros optimizados de her1 y her3 y sus metodos de uso.

Info

Publication number
MX2010003757A
MX2010003757A MX2010003757A MX2010003757A MX2010003757A MX 2010003757 A MX2010003757 A MX 2010003757A MX 2010003757 A MX2010003757 A MX 2010003757A MX 2010003757 A MX2010003757 A MX 2010003757A MX 2010003757 A MX2010003757 A MX 2010003757A
Authority
MX
Mexico
Prior art keywords
her3
multimers
optimized
compositions
her1
Prior art date
Application number
MX2010003757A
Other languages
English (en)
Inventor
H Michael Shepard
Pei Jin
Original Assignee
Symphogen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphogen As filed Critical Symphogen As
Publication of MX2010003757A publication Critical patent/MX2010003757A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

La invenci?n proporciona composiciones que comprenden mult?meros de Her3 manipulados gen?ticamente con una afinidad de uni?n mejorada. Los mult?meros incluyen, entre otras cosas, los heterod?meros de Herl/Her3 en los cuales el dominio de uni?n al ligando de Her3 ha sido optimizado para aumentar la uni?n a Her3 La composici?n tambi?n puede incluir mezclas de homod?meros de Herl, homod?meros de Her3 y heterod?meros de Herl/Her3.
MX2010003757A 2007-10-16 2008-10-15 Composiciones que comprenden multimeros optimizados de her1 y her3 y sus metodos de uso. MX2010003757A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98042407P 2007-10-16 2007-10-16
US4330808P 2008-04-08 2008-04-08
PCT/US2008/079998 WO2009052184A2 (en) 2007-10-16 2008-10-15 Compositions comprising optimized her1 and her3 multimers and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2010003757A true MX2010003757A (es) 2010-04-27

Family

ID=40254392

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003757A MX2010003757A (es) 2007-10-16 2008-10-15 Composiciones que comprenden multimeros optimizados de her1 y her3 y sus metodos de uso.

Country Status (13)

Country Link
US (1) US20100278801A1 (es)
EP (1) EP2205629A2 (es)
JP (1) JP2011500703A (es)
KR (1) KR20100082775A (es)
CN (1) CN101827860A (es)
AU (1) AU2008312580A1 (es)
BR (1) BRPI0818033A2 (es)
CA (1) CA2702740A1 (es)
MX (1) MX2010003757A (es)
RU (1) RU2010119556A (es)
TW (1) TW200932257A (es)
WO (1) WO2009052184A2 (es)
ZA (1) ZA201001880B (es)

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US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
JP5981853B2 (ja) 2010-02-18 2016-08-31 ジェネンテック， インコーポレイテッド ニューレグリンアンタゴニスト及び癌の治療におけるそれらの使用
AU2011283646B2 (en) 2010-07-30 2015-07-09 Novartis Ag Fibronectin cradle molecules and libraries thereof
CU24094B1 (es) 2010-08-20 2015-04-29 Novartis Ag Anticuerpos para el receptor 3 del factor de crecimiento epidérmico(her3)
US9522951B2 (en) 2011-10-31 2016-12-20 Bristol-Myers Squibb Company Fibronectin binding domains with reduced immunogenicity
EP3774859B1 (en) 2018-04-11 2024-03-13 Salubris Biotherapeutics, Inc. Human neuregulin-1 (nrg-1) recombinant fusion protein compositions and methods of use thereof
WO2023168426A1 (en) * 2022-03-03 2023-09-07 Enosi Therapeutics Corporation Compositions and cells containing mixtures of oligo-trap fusion proteins (ofps) and uses thereof
EP4324846A1 (en) 2022-08-16 2024-02-21 Eberhard Karls Universität Tübingen, Medizinische Fakultät Inhibitor protein of ligands of epidermal growth factor receptor (egfr)

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Also Published As

Publication number Publication date
ZA201001880B (en) 2011-10-26
TW200932257A (en) 2009-08-01
KR20100082775A (ko) 2010-07-19
WO2009052184A3 (en) 2009-06-11
BRPI0818033A2 (pt) 2015-03-24
CA2702740A1 (en) 2009-04-23
RU2010119556A (ru) 2011-11-27
WO2009052184A2 (en) 2009-04-23
JP2011500703A (ja) 2011-01-06
AU2008312580A1 (en) 2009-04-23
US20100278801A1 (en) 2010-11-04
EP2205629A2 (en) 2010-07-14
CN101827860A (zh) 2010-09-08

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