MX2009012832A - Inhibidor de pirazolopirimidinona quinasa. - Google Patents

Inhibidor de pirazolopirimidinona quinasa.

Info

Publication number
MX2009012832A
MX2009012832A MX2009012832A MX2009012832A MX2009012832A MX 2009012832 A MX2009012832 A MX 2009012832A MX 2009012832 A MX2009012832 A MX 2009012832A MX 2009012832 A MX2009012832 A MX 2009012832A MX 2009012832 A MX2009012832 A MX 2009012832A
Authority
MX
Mexico
Prior art keywords
kinase inhibitor
pyrazolopyrimidinone
pyrimidin
compound
pyrazolo
Prior art date
Application number
MX2009012832A
Other languages
English (en)
Inventor
Arthur F Kluge
Original Assignee
Agennix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agennix Ag filed Critical Agennix Ag
Publication of MX2009012832A publication Critical patent/MX2009012832A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Abstract

La presente invención proporciona una pirazolo[3,4-d]pirimidin-4-o na novedosa, específicamente un derivado de 1-(piridin-4-il)-piraz olo[3,4-d]pirimidin-4-ona. Este compuesto es un inhibidor de quinasa que muestra actividad anti-proliferativa inesperada contra las células, incluyendo contra celular de tumor, y actividad anti-tumor en modelos de tumor de xenoinjerto. El compuesto o una sal adecuada oprofármaco del mismo es útil para el tratamiento de individuos que padecen de un cáncer u otro trastorno o enfermedad proliferativa.
MX2009012832A 2007-05-29 2008-05-28 Inhibidor de pirazolopirimidinona quinasa. MX2009012832A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93215507P 2007-05-29 2007-05-29
EP07113226A EP2019101A1 (en) 2007-07-26 2007-07-26 Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor
PCT/EP2008/056569 WO2008145678A1 (en) 2007-05-29 2008-05-28 Pyrazolopyrimidinone kinase inhibitor

Publications (1)

Publication Number Publication Date
MX2009012832A true MX2009012832A (es) 2010-05-17

Family

ID=38556321

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012832A MX2009012832A (es) 2007-05-29 2008-05-28 Inhibidor de pirazolopirimidinona quinasa.

Country Status (19)

Country Link
US (2) US8304418B2 (es)
EP (2) EP2019101A1 (es)
JP (1) JP2010528088A (es)
KR (1) KR20100040806A (es)
CN (1) CN101765600A (es)
AR (1) AR066737A1 (es)
AT (1) ATE522533T1 (es)
AU (1) AU2008257534A1 (es)
CA (1) CA2689090A1 (es)
DK (1) DK2170891T3 (es)
EA (1) EA200901536A1 (es)
ES (1) ES2370677T3 (es)
HR (1) HRP20110768T1 (es)
IL (1) IL202375A0 (es)
MX (1) MX2009012832A (es)
SI (1) SI2170891T1 (es)
TW (1) TW200906831A (es)
WO (1) WO2008145678A1 (es)
ZA (1) ZA200908943B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8586598B2 (en) * 2009-04-29 2013-11-19 Nerviano Medical Sciences S.R.L. CDK inhibitor salts
US9498471B2 (en) 2011-10-20 2016-11-22 The Regents Of The University Of California Use of CDK9 inhibitors to reduce cartilage degradation
WO2015172713A1 (zh) * 2014-05-13 2015-11-19 广东东阳光药业有限公司 一种中间体的制备方法
WO2016061144A1 (en) 2014-10-14 2016-04-21 The Regents Of The University Of California Use of cdk9 and brd4 inhibitors to inhibit inflammation

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US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
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US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
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US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
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JP2005511535A (ja) * 2001-10-15 2005-04-28 ジーピーシー バイオテック インク． サイクリン依存性キナーゼの阻害剤、組成物及びその使用
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Also Published As

Publication number Publication date
TW200906831A (en) 2009-02-16
IL202375A0 (en) 2010-06-30
ATE522533T1 (de) 2011-09-15
DK2170891T3 (da) 2011-12-12
AR066737A1 (es) 2009-09-09
AU2008257534A1 (en) 2008-12-04
KR20100040806A (ko) 2010-04-21
ES2370677T3 (es) 2011-12-21
US8304418B2 (en) 2012-11-06
SI2170891T1 (sl) 2011-12-30
EP2170891A1 (en) 2010-04-07
EA200901536A1 (ru) 2010-06-30
EP2019101A1 (en) 2009-01-28
ZA200908943B (en) 2010-08-25
JP2010528088A (ja) 2010-08-19
WO2008145678A1 (en) 2008-12-04
EP2170891B1 (en) 2011-08-31
CN101765600A (zh) 2010-06-30
HRP20110768T1 (hr) 2011-11-30
CA2689090A1 (en) 2008-12-04
US20100160350A1 (en) 2010-06-24
US20130035349A1 (en) 2013-02-07

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