MX2009009701A - Agente preventivo y/o terapeutico novedoso para neuropatia diabetica. - Google Patents

Agente preventivo y/o terapeutico novedoso para neuropatia diabetica.

Info

Publication number
MX2009009701A
MX2009009701A MX2009009701A MX2009009701A MX2009009701A MX 2009009701 A MX2009009701 A MX 2009009701A MX 2009009701 A MX2009009701 A MX 2009009701A MX 2009009701 A MX2009009701 A MX 2009009701A MX 2009009701 A MX2009009701 A MX 2009009701A
Authority
MX
Mexico
Prior art keywords
diabetic
therapeutic agent
prophylactic
nerve disorder
abnormal
Prior art date
Application number
MX2009009701A
Other languages
English (en)
Inventor
Toshiaki Aoki
Nobuhito Murai
Seiji Tamura
Hiroko Yamamoto
Nozomu Hamakawa
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009009701A publication Critical patent/MX2009009701A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se describe un agente profiláctico y/o terapéutico excelente para neuropatía diabética, el cual comprende 2- [(indeno-7-iloxi substituido)metil]morfolina representado por la fórmula (I) o una sal farmacéuticamente aceptable del mismo como un ingrediente activo. El agente profiláctico y/o terapéutico es particularmente útil como un agente profiláctico y/o terapéutico para trastorno de nervio motor diabético (por ejemplo, disminución en fuerza muscular (disminución en fuerza muscular hasta un grado de ser incapaz de caminar independientemente)), trastorno de nervio sensorial diabético (parestesia (sensación de vibración anormal), alodinia, sensación reducida (entumecimiento de extremidades, psicroestesia) o dolor), o trastorno de nervio autónomo diabético (por ejemplo, habituación anormal del intestino, tal como constipación y diarrea, disfunción urinaria, impotencia, hipotensión ortoestática, dishidrosis, variabilidad anormal en frecuencia cardíaca, vaciamiento gástrico retardado). También se describe un agente de disminución de una condición de enfermedad de un trastorno de nervio diabético.
MX2009009701A 2007-03-15 2008-03-14 Agente preventivo y/o terapeutico novedoso para neuropatia diabetica. MX2009009701A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007066727 2007-03-15
JP2007242210 2007-09-19
PCT/JP2008/054710 WO2008111669A1 (ja) 2007-03-15 2008-03-14 糖尿病性神経障害の新規予防剤及び／又は治療剤

Publications (1)

Publication Number Publication Date
MX2009009701A true MX2009009701A (es) 2009-10-07

Family

ID=39759597

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009701A MX2009009701A (es) 2007-03-15 2008-03-14 Agente preventivo y/o terapeutico novedoso para neuropatia diabetica.

Country Status (12)

Country Link
US (2) US20100113451A1 (es)
EP (1) EP2123643A4 (es)
JP (1) JP5278308B2 (es)
KR (1) KR20090130052A (es)
AU (1) AU2008225379A1 (es)
BR (1) BRPI0808806A2 (es)
CA (1) CA2680938A1 (es)
IL (1) IL200669A0 (es)
MX (1) MX2009009701A (es)
RU (1) RU2465906C2 (es)
TW (1) TW200846003A (es)
WO (1) WO2008111669A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2736560A1 (en) 2008-09-11 2010-03-18 Astellas Pharma Inc. Novel salt of morpholine derivative
EP2329824A4 (en) 2008-09-11 2013-01-16 Astellas Pharma Inc NEW PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF NOZIZEPTIVE PAIN

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109088A (en) * 1975-01-29 1978-08-22 Yamanouchi Pharmaceutical Co., Ltd. 2-(indenyloxymethyl) morpholine derivatives
JPS52111580A (en) * 1976-03-15 1977-09-19 Yamanouchi Pharmaceut Co Ltd Novel indene derivatives and salts thereof
AU670675B2 (en) * 1993-02-10 1996-07-25 Yamanouchi Pharmaceutical Co., Ltd. Morpholine derivative
EP1113797B1 (en) * 1998-09-15 2009-11-25 Eli Lilly And Company Use of duloxetine for the treatment of fibromyalgia
US6380200B1 (en) * 1999-12-07 2002-04-30 Pfizer, Inc. Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
WO2005105763A1 (en) * 2004-04-30 2005-11-10 Warner-Lambert Company Llc Substituted morpholine compounds for the treatment of central nervous system disorders
EP1767217A1 (en) * 2004-07-14 2007-03-28 Astellas Pharma Inc. Agent for promoting the recovery from dysfunction after the onset of central neurological disease
CA2607219A1 (en) * 2005-05-18 2007-02-15 Neuraxon, Inc. Substituted benzimidazole compounds with dual nos inhibitory activity and mu opioid agonist activity
EA200802412A1 (ru) * 2006-06-08 2009-06-30 Шварц Фарма Аг Терапевтические комбинации для сопровождающихся болью медицинских состояний

Also Published As

Publication number Publication date
EP2123643A1 (en) 2009-11-25
CA2680938A1 (en) 2008-09-18
WO2008111669A1 (ja) 2008-09-18
EP2123643A4 (en) 2011-12-07
BRPI0808806A2 (pt) 2014-08-19
TW200846003A (en) 2008-12-01
US20100113451A1 (en) 2010-05-06
RU2465906C2 (ru) 2012-11-10
US20130023535A1 (en) 2013-01-24
AU2008225379A1 (en) 2008-09-18
IL200669A0 (en) 2010-05-17
KR20090130052A (ko) 2009-12-17
JPWO2008111669A1 (ja) 2010-06-24
JP5278308B2 (ja) 2013-09-04
RU2009138032A (ru) 2011-04-20

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Legal Events

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FA Abandonment or withdrawal