MX2009008874A - Metodos para identificar activadores de cinasa lyn. - Google Patents
Metodos para identificar activadores de cinasa lyn.Info
- Publication number
- MX2009008874A MX2009008874A MX2009008874A MX2009008874A MX2009008874A MX 2009008874 A MX2009008874 A MX 2009008874A MX 2009008874 A MX2009008874 A MX 2009008874A MX 2009008874 A MX2009008874 A MX 2009008874A MX 2009008874 A MX2009008874 A MX 2009008874A
- Authority
- MX
- Mexico
- Prior art keywords
- lyn kinase
- methods
- substrate
- test compound
- identifying activators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a métodos para identificar activadores de cinasa Lyn al preincubar un compuesto de prueba en presencia de cinasa Lyn; añadir ATP y substrato a la cinasa Lyn y compuesto de prueba; incubar el compuesto de prueba, cinasa Lyn, ATP y substrato, y medir el nivel de fosforilación del substrato, con lo cual un incremento en el nivel de fosforilación del substrato indica que el compuesto de prueba es un activador de cinasa Lyn.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89063207P | 2007-02-20 | 2007-02-20 | |
PCT/US2008/054361 WO2008103692A2 (en) | 2007-02-20 | 2008-02-20 | Methods of identifying activators of lyn kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009008874A true MX2009008874A (es) | 2009-10-20 |
Family
ID=39710712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008874A MX2009008874A (es) | 2007-02-20 | 2008-02-20 | Metodos para identificar activadores de cinasa lyn. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100152215A1 (es) |
EP (1) | EP2120581A4 (es) |
JP (1) | JP2010518860A (es) |
KR (1) | KR20100014480A (es) |
CN (1) | CN101686686A (es) |
AU (1) | AU2008218765A1 (es) |
BR (1) | BRPI0807928A2 (es) |
CA (1) | CA2678813A1 (es) |
IL (1) | IL200429A0 (es) |
MX (1) | MX2009008874A (es) |
NZ (1) | NZ579227A (es) |
WO (1) | WO2008103692A2 (es) |
ZA (1) | ZA200905776B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
GB201010196D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
CN102507707B (zh) * | 2011-10-12 | 2015-10-21 | 山东大学 | 一种检测龈沟液中蛋白裂解酶含量的方法 |
US9827222B2 (en) * | 2013-07-01 | 2017-11-28 | Emory University | Treating or preventing nephrogenic diabetes insipidus |
JP6584322B2 (ja) | 2013-12-27 | 2019-10-02 | 国立大学法人 東京医科歯科大学 | アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法 |
EP3755334A4 (en) * | 2018-02-21 | 2022-03-23 | Melior Pharmaceuticals I, Inc. | TREATMENT OF LIVER DISEASES |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
US3922345A (en) * | 1971-10-29 | 1975-11-25 | Pfizer | Pyrimidinones and hydroxy pyrimidines |
US4080454A (en) * | 1976-07-16 | 1978-03-21 | Pfizer Inc. | 5-M-Tolyloxyuracil, anti-ulcer agent |
US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
US5476855A (en) * | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
US6900304B2 (en) * | 1996-01-31 | 2005-05-31 | The Regents Of The University Of California | Emission ratiometric indicators of phosphorylation |
US20020019346A1 (en) * | 1997-05-21 | 2002-02-14 | Children's Medical Center Corporation | Treatment of prostate cancer by inhibiting lyn tyrosine kinase |
US6037323A (en) * | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6004925A (en) * | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6410255B1 (en) * | 1999-05-05 | 2002-06-25 | Aurora Biosciences Corporation | Optical probes and assays |
GB0104422D0 (en) * | 2001-02-22 | 2001-04-11 | Glaxo Group Ltd | Quinoline derivative |
US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
US20050009817A1 (en) * | 2003-04-30 | 2005-01-13 | Jennifer Savoy | Substituted heteroaryls |
EP1541694A1 (en) * | 2003-12-12 | 2005-06-15 | Sirenade Pharmaceuticals AG | Methods of identifying, selecting and/or characterizing compounds which modulate the activity of a Src family kinase |
US20060035302A1 (en) * | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
CA2587642C (en) * | 2004-11-30 | 2013-04-09 | Amgen Inc. | Substituted heterocycles and methods of use |
ITUD20050112A1 (it) * | 2005-07-01 | 2007-01-02 | Gaetano Azzolina | Dispositivo di assistenza cardiocircolatoria |
TWI273177B (en) * | 2005-07-08 | 2007-02-11 | Ama Precision Inc | Fan apparatus with adapting device |
WO2007016975A1 (en) * | 2005-07-29 | 2007-02-15 | F. Hoffmann-La Roche Ag | Kinase and phosphatase assays based on fret |
CA2620065C (en) * | 2005-08-22 | 2011-03-29 | Melior Discovery, Inc. | Methods and formulations for modulating lyn kinase activity and treating related disorders |
US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
-
2008
- 2008-02-20 MX MX2009008874A patent/MX2009008874A/es not_active Application Discontinuation
- 2008-02-20 AU AU2008218765A patent/AU2008218765A1/en not_active Abandoned
- 2008-02-20 EP EP08730208A patent/EP2120581A4/en not_active Withdrawn
- 2008-02-20 JP JP2009550979A patent/JP2010518860A/ja active Pending
- 2008-02-20 WO PCT/US2008/054361 patent/WO2008103692A2/en active Application Filing
- 2008-02-20 US US12/527,801 patent/US20100152215A1/en not_active Abandoned
- 2008-02-20 CA CA002678813A patent/CA2678813A1/en not_active Abandoned
- 2008-02-20 NZ NZ579227A patent/NZ579227A/xx not_active IP Right Cessation
- 2008-02-20 CN CN200880012768A patent/CN101686686A/zh active Pending
- 2008-02-20 KR KR1020097019560A patent/KR20100014480A/ko not_active Application Discontinuation
- 2008-02-20 BR BRPI0807928-5A patent/BRPI0807928A2/pt not_active IP Right Cessation
-
2009
- 2009-08-17 IL IL200429A patent/IL200429A0/en unknown
- 2009-08-19 ZA ZA200905776A patent/ZA200905776B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0807928A2 (pt) | 2014-07-08 |
ZA200905776B (en) | 2010-05-26 |
KR20100014480A (ko) | 2010-02-10 |
WO2008103692A2 (en) | 2008-08-28 |
EP2120581A4 (en) | 2011-03-16 |
AU2008218765A1 (en) | 2008-08-28 |
NZ579227A (en) | 2012-11-30 |
IL200429A0 (en) | 2010-04-29 |
CA2678813A1 (en) | 2008-08-28 |
US20100152215A1 (en) | 2010-06-17 |
WO2008103692A3 (en) | 2008-10-23 |
JP2010518860A (ja) | 2010-06-03 |
EP2120581A2 (en) | 2009-11-25 |
CN101686686A (zh) | 2010-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |