MX2009006881A - Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido. - Google Patents

Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido.

Info

Publication number
MX2009006881A
MX2009006881A MX2009006881A MX2009006881A MX2009006881A MX 2009006881 A MX2009006881 A MX 2009006881A MX 2009006881 A MX2009006881 A MX 2009006881A MX 2009006881 A MX2009006881 A MX 2009006881A MX 2009006881 A MX2009006881 A MX 2009006881A
Authority
MX
Mexico
Prior art keywords
cyclopropane
sulfonyl
substituted
ccr
preparing
Prior art date
Application number
MX2009006881A
Other languages
English (en)
Inventor
Shen-Chun Kuo
Feng Liang
John F Traverse
William W Leong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009006881A publication Critical patent/MX2009006881A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención revela un proceso nuevo para preparar compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido, que son intermediarios útiles para la preparación de antagonistas del receptor CCR5 y por lo tanto útiles para el tratamiento de mamíferos infectados por el virus VIH. Específicamente revela un proceso nuevo para sintetizar compuestos de 4-[4-[(R)-[1-[ciclopro pilsulfonil)-4-piperidinil](3-fluorofenil)metil]-3(S)-metil-1-pip erazinil]-1-[(4,6-dimetil-5-pirimidinil)carbonil]-4-metilpiperidi na].
MX2009006881A 2006-12-22 2007-12-20 Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido. MX2009006881A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87688806P 2006-12-22 2006-12-22
PCT/US2007/026049 WO2008079284A1 (en) 2006-12-22 2007-12-20 Process for preparing ccr-5 receptor antagonists utilizing 4-substituted 1-cyclopropane-sulfonyl-piperidinyl compounds

Publications (1)

Publication Number Publication Date
MX2009006881A true MX2009006881A (es) 2009-07-03

Family

ID=39367127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006881A MX2009006881A (es) 2006-12-22 2007-12-20 Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido.

Country Status (7)

Country Link
US (1) US20100063280A1 (es)
EP (1) EP2125733A1 (es)
JP (1) JP2010513521A (es)
AR (1) AR064502A1 (es)
CA (1) CA2673233A1 (es)
MX (1) MX2009006881A (es)
WO (1) WO2008079284A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7697827B2 (en) 2005-10-17 2010-04-13 Konicek Jeffrey C User-friendlier interfaces for a camera

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE466009T1 (de) * 2001-03-29 2010-05-15 Schering Corp Ccr5 antagonisten verwendbar für die behandlung von aids
PE20040769A1 (es) * 2002-12-18 2004-11-06 Schering Corp Derivados de piperidina utiles como antagonisas ccr5
AR054422A1 (es) * 2005-01-06 2007-06-27 Schering Corp Sintesis de los antagonistas del receptor ccr5. compuestos relacionados

Also Published As

Publication number Publication date
CA2673233A1 (en) 2008-07-03
AR064502A1 (es) 2009-04-08
JP2010513521A (ja) 2010-04-30
US20100063280A1 (en) 2010-03-11
WO2008079284A1 (en) 2008-07-03
EP2125733A1 (en) 2009-12-02

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