MX2009005919A - Preparacion de 3,4-dihidroisoquinolinas de un acido y una amina. - Google Patents
Preparacion de 3,4-dihidroisoquinolinas de un acido y una amina.Info
- Publication number
- MX2009005919A MX2009005919A MX2009005919A MX2009005919A MX2009005919A MX 2009005919 A MX2009005919 A MX 2009005919A MX 2009005919 A MX2009005919 A MX 2009005919A MX 2009005919 A MX2009005919 A MX 2009005919A MX 2009005919 A MX2009005919 A MX 2009005919A
- Authority
- MX
- Mexico
- Prior art keywords
- amine
- dihydroisoquinoline
- carboxylic acid
- dihydroisoquinolines
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/77—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a procesos para la síntesis de morfinanos. En particular, un proceso de acoplamiento de un compuesto de ácido carboxílico con un compuesto de amina para obtener un producto de amida que se puede aislar o el producto de amida crudo se puede ciclar para obtener una 3,4-dihidroisoquinoli na. En una modalidad, el ácido carboxílico contiene un resto fenol protegido con un grupo protector lábil. El fenol protegido reduce los tiempos de reacción, simplifica el tratamiento del producto y reduce la cantidad de agente de ciclación, POCl3, que se necesita para obtener la 3,4-dihidroisoquinolina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87413106P | 2006-12-11 | 2006-12-11 | |
PCT/US2007/025263 WO2008073390A2 (en) | 2006-12-11 | 2007-12-10 | Preparation of 3,4-dihydroisoquinolines from an acid and an amine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005919A true MX2009005919A (es) | 2009-06-16 |
Family
ID=39264539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005919A MX2009005919A (es) | 2006-12-11 | 2007-12-10 | Preparacion de 3,4-dihidroisoquinolinas de un acido y una amina. |
Country Status (8)
Country | Link |
---|---|
US (3) | US8445682B2 (es) |
EP (3) | EP2099745A2 (es) |
JP (4) | JP2010512392A (es) |
CN (3) | CN101638386A (es) |
AU (3) | AU2007332773B2 (es) |
CA (3) | CA2672744C (es) |
MX (1) | MX2009005919A (es) |
WO (1) | WO2008073390A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
CZ302637B6 (cs) * | 2010-01-05 | 2011-08-10 | Zentiva, K. S | Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu |
CN103965108B (zh) * | 2013-02-06 | 2015-09-23 | 公安部禁毒情报技术中心 | 一种合成劳丹宁的方法 |
CN103965109B (zh) * | 2013-02-06 | 2015-08-19 | 公安部禁毒情报技术中心 | 一种合成可旦民碱的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE922827C (de) * | 1951-02-08 | 1955-01-27 | Knoll Ag | Verfahren zur Herstellung von quartaeren Ammoniumsalzen, die 2 Tetrahydroisochinolinreste enthalten |
US4368326A (en) | 1980-07-03 | 1983-01-11 | Rice Kenner C | Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
US4521601A (en) | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
US4991391A (en) | 1989-01-27 | 1991-02-12 | Westinghouse Electric Corp. | System for cooling in a gas turbine |
CN1045442C (zh) | 1994-07-20 | 1999-10-06 | 中国科学院上海药物研究所 | 左、右旋氯斯库利啉及它的制备方法和用途 |
ES2172376B1 (es) | 2000-01-28 | 2003-11-16 | Servier Lab | Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
US6887999B1 (en) | 2004-05-21 | 2005-05-03 | Acura Pharmaceuticals, Inc. | Preparation of dihydrocodeine from codeine |
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2007
- 2007-12-10 EP EP07853328A patent/EP2099745A2/en not_active Ceased
- 2007-12-10 JP JP2009541334A patent/JP2010512392A/ja not_active Withdrawn
- 2007-12-10 AU AU2007332773A patent/AU2007332773B2/en active Active
- 2007-12-10 CA CA2672744A patent/CA2672744C/en active Active
- 2007-12-10 CN CN200910160285A patent/CN101638386A/zh active Pending
- 2007-12-10 EP EP09010301A patent/EP2161253A3/en not_active Ceased
- 2007-12-10 CN CN200910160284A patent/CN101665444A/zh active Pending
- 2007-12-10 CN CNA2007800458376A patent/CN101558035A/zh active Pending
- 2007-12-10 MX MX2009005919A patent/MX2009005919A/es not_active Application Discontinuation
- 2007-12-10 CA CA2670834A patent/CA2670834C/en active Active
- 2007-12-10 WO PCT/US2007/025263 patent/WO2008073390A2/en active Application Filing
- 2007-12-10 EP EP09010302A patent/EP2177504A1/en not_active Ceased
- 2007-12-10 US US12/518,434 patent/US8445682B2/en active Active
- 2007-12-10 CA CA2674099A patent/CA2674099C/en active Active
-
2009
- 2009-06-10 US US12/482,014 patent/US8232400B2/en active Active
- 2009-06-10 US US12/481,993 patent/US8461384B2/en active Active
- 2009-07-10 AU AU2009202790A patent/AU2009202790B2/en active Active
- 2009-07-10 AU AU2009202789A patent/AU2009202789B2/en active Active
-
2010
- 2010-12-09 JP JP2010275152A patent/JP5412416B2/ja active Active
- 2010-12-09 JP JP2010275153A patent/JP5275328B2/ja active Active
-
2013
- 2013-02-26 JP JP2013035340A patent/JP2013100363A/ja not_active Withdrawn
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Legal Events
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FA | Abandonment or withdrawal |