MX2009005773A - Proceso para la produccion de acido clavulanico. - Google Patents
Proceso para la produccion de acido clavulanico.Info
- Publication number
- MX2009005773A MX2009005773A MX2009005773A MX2009005773A MX2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A
- Authority
- MX
- Mexico
- Prior art keywords
- clavulanic acid
- metal
- acid containing
- salt
- insoluble
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona con un proceso para la preparación de una sal metálica farmacéuticamente aceptable del ácido clavulánico que comprende las etapas de (a) fermentar con un microorganismo capaz de producir y excretar el ácido clavulánico en el caldo; (b) remover la biomasa y otro material sólido del caldo de fermentación que contiene el ácido clavulánico obtenido en la etapa (a); (c) acidificar la solución obtenida después de la etapa (b) a un pH entre 1 y 3 y extraer la solución acidificada con un solvente parcial o totalmente inmiscible con agua y separar el extracto que contiene el ácido clavulánico; (d) mezclar el extracto que contiene el ácido clavulánico obtenido en la etapa (c) con un donador de metal y al menos un cosolvente adicional para producir una sal metálica de clavulanato preferiblemente cristalina, insoluble, con un rendimiento de al menos 80%; y (e) separar la sal metálica de clavulanato, preferiblemente cristalina, insoluble de la mezcla obtenida en la etapa (d).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125246 | 2006-12-01 | ||
PCT/EP2007/062994 WO2008065160A1 (en) | 2006-12-01 | 2007-11-29 | Process for the production of clavulanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005773A true MX2009005773A (es) | 2009-06-08 |
Family
ID=38030243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005773A MX2009005773A (es) | 2006-12-01 | 2007-11-29 | Proceso para la produccion de acido clavulanico. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100055749A1 (es) |
EP (1) | EP2106448A1 (es) |
KR (1) | KR20090094261A (es) |
CN (1) | CN101548018A (es) |
CA (1) | CA2669931A1 (es) |
MX (1) | MX2009005773A (es) |
WO (1) | WO2008065160A1 (es) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
CN1238776A (zh) * | 1996-11-11 | 1999-12-15 | 吉斯特-布罗卡迪斯有限公司 | 制备棒酸盐和酯的方法 |
PT867515E (pt) * | 1997-03-24 | 2000-05-31 | Cipan Companhia Ind P De Antib | Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel |
PT101992A (pt) * | 1997-04-14 | 1998-11-30 | Cipan Comp Ind Produtora De An | Processo de isolamento de um sal de um metal alcalino do acido clavulanico farmaceuticamente aceitavel |
EP1095046A1 (en) * | 1998-07-16 | 2001-05-02 | Dsm N.V. | Improved process for the preparation of salts and esters of clavulanic acid |
EP1670580A1 (en) * | 2003-10-10 | 2006-06-21 | DSM IP Assets B.V. | Activated carbon treatment |
-
2007
- 2007-11-29 WO PCT/EP2007/062994 patent/WO2008065160A1/en active Application Filing
- 2007-11-29 CA CA002669931A patent/CA2669931A1/en not_active Abandoned
- 2007-11-29 EP EP07847510A patent/EP2106448A1/en not_active Withdrawn
- 2007-11-29 US US12/517,139 patent/US20100055749A1/en not_active Abandoned
- 2007-11-29 KR KR1020097011094A patent/KR20090094261A/ko not_active Application Discontinuation
- 2007-11-29 CN CNA2007800444759A patent/CN101548018A/zh active Pending
- 2007-11-29 MX MX2009005773A patent/MX2009005773A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2008065160A1 (en) | 2008-06-05 |
CA2669931A1 (en) | 2008-06-05 |
KR20090094261A (ko) | 2009-09-04 |
EP2106448A1 (en) | 2009-10-07 |
CN101548018A (zh) | 2009-09-30 |
US20100055749A1 (en) | 2010-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |