MX2009004648A - Proceso para la preparacion de 2,5-bis-(2,2,2-trifluoroetoxi)-n-(2 -piperidilmetil)-benzamida y sales de la misma. - Google Patents

Proceso para la preparacion de 2,5-bis-(2,2,2-trifluoroetoxi)-n-(2 -piperidilmetil)-benzamida y sales de la misma.

Info

Publication number
MX2009004648A
MX2009004648A MX2009004648A MX2009004648A MX2009004648A MX 2009004648 A MX2009004648 A MX 2009004648A MX 2009004648 A MX2009004648 A MX 2009004648A MX 2009004648 A MX2009004648 A MX 2009004648A MX 2009004648 A MX2009004648 A MX 2009004648A
Authority
MX
Mexico
Prior art keywords
bis
piperidylmethyl
trifluoroethoxy
benzamide
preparation
Prior art date
Application number
MX2009004648A
Other languages
English (en)
Inventor
Daina Zicane
Janis Jaunbergs
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of MX2009004648A publication Critical patent/MX2009004648A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond

Abstract

La presente invención se refiere a un proceso para la preparación de 2,5-bis (2,2, 2-trifluoroetoxi)-N-'(2- piperidilmetil)benzamida , sus sales farmacéuticamente aceptables e intermediarios importantes de la misma que involucra 1,4-dihalotolueno como material de partida. El método involucra una técnica para preparar el material de partida 2,5-bis (2,2,2-trifluoroetoxi)tolu eno con altos rendimientos haciendo reaccionar 1,4-dibromotolueno con 2,2,2-trifluoroetai-iol en la presencia de una base y un catalizador que contiene cobre.
MX2009004648A 2006-11-06 2007-11-02 Proceso para la preparacion de 2,5-bis-(2,2,2-trifluoroetoxi)-n-(2 -piperidilmetil)-benzamida y sales de la misma. MX2009004648A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123547A EP1918280A1 (en) 2006-11-06 2006-11-06 Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof
PCT/EP2007/061820 WO2008055851A1 (en) 2006-11-06 2007-11-02 Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidylmethyl)-benzamide and salts thereof

Publications (1)

Publication Number Publication Date
MX2009004648A true MX2009004648A (es) 2009-05-21

Family

ID=37965028

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009004648A MX2009004648A (es) 2006-11-06 2007-11-02 Proceso para la preparacion de 2,5-bis-(2,2,2-trifluoroetoxi)-n-(2 -piperidilmetil)-benzamida y sales de la misma.
MX2009004647A MX2009004647A (es) 2006-11-06 2007-11-02 Proceso para la preparacion de trifluoroetoxitoluenos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009004647A MX2009004647A (es) 2006-11-06 2007-11-02 Proceso para la preparacion de trifluoroetoxitoluenos.

Country Status (14)

Country Link
US (2) US20100056794A1 (es)
EP (3) EP1918280A1 (es)
JP (2) JP2010508331A (es)
KR (2) KR20090064456A (es)
CN (2) CN101516845A (es)
AT (1) ATE514670T1 (es)
AU (2) AU2007316692A1 (es)
BR (2) BRPI0714991A2 (es)
CA (2) CA2660358A1 (es)
EA (2) EA200900356A1 (es)
MX (2) MX2009004648A (es)
PL (1) PL2079674T3 (es)
WO (2) WO2008055849A1 (es)
ZA (2) ZA200902184B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102977003A (zh) * 2012-11-28 2013-03-20 郑州大明药物科技有限公司 醋酸氟卡胺的制备方法
CN111018694A (zh) * 2019-12-12 2020-04-17 贵州省欣紫鸿药用辅料有限公司 一种氟卡尼的生产方法
CN115368786B (zh) * 2022-08-15 2023-05-09 江阴市华昌不锈钢管有限公司 一种超级奥氏体耐高温、耐腐蚀不锈钢焊管的制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3900481A (en) * 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4617396A (en) * 1979-03-19 1986-10-14 Riker Laboratories, Inc. Process for the preparation of derivatives of piperidine
IL120715A (en) * 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
DE10025700A1 (de) * 2000-05-26 2001-11-29 Merck Patent Gmbh Verfahren zur Herstellung von trifluorethoxysubstituierten Benzoesäuren
US6458957B1 (en) * 2000-07-12 2002-10-01 Geneva Pharmaceuticals, Inc. α,α-dibromo-α-chloro-acetophenones as synthons
ITMI20011772A1 (it) * 2001-08-10 2003-02-10 A M S A Anonima Materie Sint E Processo per la preparazione della 2,5-bis-(2,2,2-trifluoroetossi)-n-(2-piperidilmetil)-benzamide(flecainide)
US7196197B2 (en) * 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof

Also Published As

Publication number Publication date
ZA200902184B (en) 2010-03-31
CA2660358A1 (en) 2008-05-15
MX2009004647A (es) 2009-05-20
JP2010508330A (ja) 2010-03-18
CA2660364A1 (en) 2008-05-15
EA200900356A1 (ru) 2009-10-30
WO2008055851A8 (en) 2009-04-09
EA200900357A1 (ru) 2009-10-30
WO2008055851A1 (en) 2008-05-15
CN101516817A (zh) 2009-08-26
ATE514670T1 (de) 2011-07-15
AU2007316692A1 (en) 2008-05-15
JP2010508331A (ja) 2010-03-18
WO2008055849A1 (en) 2008-05-15
EP1918280A1 (en) 2008-05-07
EP2079674B1 (en) 2011-06-29
BRPI0714989A2 (pt) 2013-07-30
US20100063292A1 (en) 2010-03-11
US20100056794A1 (en) 2010-03-04
ZA200902183B (en) 2010-07-28
KR20090055638A (ko) 2009-06-02
KR20090064456A (ko) 2009-06-18
EP2079674A1 (en) 2009-07-22
CN101516845A (zh) 2009-08-26
BRPI0714991A2 (pt) 2013-07-30
PL2079674T3 (pl) 2011-11-30
AU2007316690A1 (en) 2008-05-15
EP2079692A1 (en) 2009-07-22

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