MX2009002853A - Tratamiento de linfomas no hodgkin con conjugados polimericos de multibrazo de 7-etil-10-hidroxicamptotecina. - Google Patents
Tratamiento de linfomas no hodgkin con conjugados polimericos de multibrazo de 7-etil-10-hidroxicamptotecina.Info
- Publication number
- MX2009002853A MX2009002853A MX2009002853A MX2009002853A MX2009002853A MX 2009002853 A MX2009002853 A MX 2009002853A MX 2009002853 A MX2009002853 A MX 2009002853A MX 2009002853 A MX2009002853 A MX 2009002853A MX 2009002853 A MX2009002853 A MX 2009002853A
- Authority
- MX
- Mexico
- Prior art keywords
- cr22r23
- dose
- substituted
- cr24r25
- body surface
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84493806P | 2006-09-15 | 2006-09-15 | |
US86451606P | 2006-11-06 | 2006-11-06 | |
US11/704,607 US7462627B2 (en) | 2006-02-09 | 2007-02-09 | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
PCT/US2007/076241 WO2008033643A2 (en) | 2006-09-15 | 2007-08-17 | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009002853A true MX2009002853A (es) | 2009-03-27 |
Family
ID=39184444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009002853A MX2009002853A (es) | 2006-09-15 | 2007-08-17 | Tratamiento de linfomas no hodgkin con conjugados polimericos de multibrazo de 7-etil-10-hidroxicamptotecina. |
Country Status (11)
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
CA2732508C (en) | 2008-08-11 | 2016-03-15 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
WO2010025337A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
PT2349346T (pt) * | 2008-09-23 | 2019-10-24 | Nektar Therapeutics | Método de dosagem metronómica com profármacos de camptotecina (e.g. peg-irinotecano). |
WO2010048018A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
CA2760771A1 (en) * | 2009-05-04 | 2010-11-11 | Intezyne Technologies, Incorporated | Polymer micelles containing sn-38 for the treatment of cancer |
US20120171201A1 (en) * | 2009-07-22 | 2012-07-05 | Enzon Pharmaceuticals, Inc. | Methods of treating her2 positive cancer with her2 receptor antagonist in combination with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
EP2501413B1 (en) * | 2009-11-18 | 2019-03-27 | Nektar Therapeutics | Acid salt forms of polymer-drug conjugates |
US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
KR102320753B1 (ko) | 2013-10-04 | 2021-11-02 | 프로린크스 엘엘시 | Sn-38 서방성 컨쥬게이트 |
CN104650342B (zh) * | 2013-11-18 | 2018-07-10 | 江苏豪森药业集团有限公司 | 多支链聚合药物前体及其应用 |
CN108727582B (zh) * | 2017-04-21 | 2021-11-05 | 博瑞生物医药(苏州)股份有限公司 | 靶向抗癌偶联物 |
AU2019206623A1 (en) | 2018-01-12 | 2020-07-16 | Prolynx Llc | Synergistic cancer treatment |
CN110577550A (zh) * | 2018-06-08 | 2019-12-17 | 遵义医学院 | 喜树碱-甘氨酸-去甲斑蝥素结合物及其应用 |
WO2022035843A1 (en) * | 2020-08-12 | 2022-02-17 | Nanomedicine Innovation Center, Llc | Topoisomerase inhibitors |
WO2022064052A1 (en) | 2020-09-28 | 2022-03-31 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Peptidic conjugates of sn38 useful in the treatment of cancer |
WO2023095741A1 (ja) * | 2021-11-25 | 2023-06-01 | 日油株式会社 | 医療用4分岐型水溶性ポリマー |
WO2023186822A1 (en) | 2022-03-28 | 2023-10-05 | Hospital Sant Joan De Deu | Peptidic water-soluble delivery system of anticancer drugs |
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US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
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KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
-
2007
- 2007-02-09 US US11/704,607 patent/US7462627B2/en not_active Expired - Fee Related
- 2007-08-17 CN CN2007800343014A patent/CN101707888B/zh not_active Expired - Fee Related
- 2007-08-17 AU AU2007297042A patent/AU2007297042B2/en not_active Ceased
- 2007-08-17 EP EP07814225A patent/EP2073809A4/en not_active Withdrawn
- 2007-08-17 BR BRPI0716807-1A patent/BRPI0716807A2/pt not_active IP Right Cessation
- 2007-08-17 CA CA002662920A patent/CA2662920A1/en not_active Abandoned
- 2007-08-17 KR KR1020147035602A patent/KR20150005721A/ko not_active Application Discontinuation
- 2007-08-17 JP JP2009528374A patent/JP2010503691A/ja active Pending
- 2007-08-17 MX MX2009002853A patent/MX2009002853A/es not_active Application Discontinuation
- 2007-08-17 WO PCT/US2007/076241 patent/WO2008033643A2/en active Application Filing
- 2007-08-17 KR KR1020097005140A patent/KR20090059117A/ko not_active Application Discontinuation
-
2008
- 2008-11-20 US US12/274,474 patent/US7723351B2/en not_active Expired - Fee Related
-
2009
- 2009-02-19 IL IL197122A patent/IL197122A0/en unknown
-
2010
- 2010-04-19 US US12/762,434 patent/US8299089B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7462627B2 (en) | 2008-12-09 |
US20070197575A1 (en) | 2007-08-23 |
JP2010503691A (ja) | 2010-02-04 |
CA2662920A1 (en) | 2008-03-20 |
WO2008033643A2 (en) | 2008-03-20 |
KR20150005721A (ko) | 2015-01-14 |
WO2008033643A3 (en) | 2008-12-11 |
AU2007297042A1 (en) | 2008-03-20 |
EP2073809A4 (en) | 2011-04-13 |
IL197122A0 (en) | 2009-11-18 |
KR20090059117A (ko) | 2009-06-10 |
CN101707888A (zh) | 2010-05-12 |
US20100204261A1 (en) | 2010-08-12 |
US8299089B2 (en) | 2012-10-30 |
US7723351B2 (en) | 2010-05-25 |
CN101707888B (zh) | 2013-05-15 |
BRPI0716807A2 (pt) | 2013-11-05 |
AU2007297042B2 (en) | 2013-01-10 |
EP2073809A2 (en) | 2009-07-01 |
US20090074706A1 (en) | 2009-03-19 |
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