MX2009000950A - Uso del antagonista del receptor de glucocorticoide para el tratamiento de padecimientos infecciosos. - Google Patents
Uso del antagonista del receptor de glucocorticoide para el tratamiento de padecimientos infecciosos.Info
- Publication number
- MX2009000950A MX2009000950A MX2009000950A MX2009000950A MX2009000950A MX 2009000950 A MX2009000950 A MX 2009000950A MX 2009000950 A MX2009000950 A MX 2009000950A MX 2009000950 A MX2009000950 A MX 2009000950A MX 2009000950 A MX2009000950 A MX 2009000950A
- Authority
- MX
- Mexico
- Prior art keywords
- glucocorticoid receptor
- mammalian subject
- treatment
- infectious conditions
- receptor antagonists
- Prior art date
Links
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 230000002458 infectious effect Effects 0.000 title abstract 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 abstract 2
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- DBLOJPKZEOYNBN-SQNIBIBYSA-N (8s,13s,14s)-13-methyl-2,6,7,8,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 DBLOJPKZEOYNBN-SQNIBIBYSA-N 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 1
- 229960003248 mifepristone Drugs 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona el uso de un antagonista del receptor de glucocorticoide para la manufactura de un medicamento para el estímulo inmune, tal como la prevención o tratamiento de infecciones o condiciones infecciosas, en un sujeto mamífero de edad avanzada, un sujeto mamífero con bajos valores de suero DHEAS, un sujeto mamífero con una alta proporción en suero de cortisol/DHEAS, o un sujeto mamífero con cuentas altas de neutrófilos. En particular el antagonista del receptor de glucocorticoide puede ser seleccionado del grupo consistente de un derivado de dibenzopiranil definido y/o ejemplificado en la Patente Norteamericana US 6329534 y el documento WO2001116128, mifepristona, y (11ß, 17ß)-11-(1,3-benzodioxol-5-il)-17-hidroxi-17 -(1-propinil)estra-4,9-dien-3-ona.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06118587 | 2006-08-08 | ||
| PCT/EP2007/058134 WO2008017658A2 (en) | 2006-08-08 | 2007-08-06 | Use of glucocorticoid receptor antagonists for treatment of infectious conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009000950A true MX2009000950A (es) | 2009-02-04 |
Family
ID=37600754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009000950A MX2009000950A (es) | 2006-08-08 | 2007-08-06 | Uso del antagonista del receptor de glucocorticoide para el tratamiento de padecimientos infecciosos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100075936A1 (es) |
| EP (2) | EP2204171A1 (es) |
| JP (1) | JP2010500323A (es) |
| KR (1) | KR20090039775A (es) |
| CN (1) | CN101500547A (es) |
| AR (1) | AR062229A1 (es) |
| AU (1) | AU2007283604A1 (es) |
| CA (1) | CA2658016A1 (es) |
| IL (1) | IL196392A0 (es) |
| MX (1) | MX2009000950A (es) |
| TW (1) | TW200820977A (es) |
| WO (1) | WO2008017658A2 (es) |
| ZA (1) | ZA200900242B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2742964C (en) | 2008-11-07 | 2020-07-07 | University Of Sheffield | Medicament and method of diagnosis |
| WO2012135274A1 (en) | 2011-03-31 | 2012-10-04 | Pop Test Cortisol Llc | Prevention of infection |
| EP2699245A4 (en) * | 2011-04-18 | 2014-12-10 | Pop Test Cortisol Llc | TREATMENT AGAINST HAIR LOSS |
| US8986677B2 (en) * | 2012-07-30 | 2015-03-24 | Pop Test Cortisol Llc | Therapeutic compositions and methods |
| EP3400233A4 (en) * | 2015-08-03 | 2020-02-26 | Pop Test Oncology LLC | PHARMACEUTICAL COMPOSITIONS AND METHODS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2696934B1 (fr) * | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| ES2092958B1 (es) * | 1995-01-10 | 1997-08-01 | Miret Lab | Procedimiento para la sintesis de tensioactivos cationicos derivados de la condensacion de acidos grasos con aminoacidos de caracter basico esterificados y su aplicacion como agentes antimicrobianos. |
| IL118974A (en) | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| EP0954317B1 (en) | 1996-04-09 | 2007-06-06 | The University Of Edinburgh | Use of 7 apha-substituted steroids to treat neuropsychiatric disorders |
| CO5180649A1 (es) | 1999-09-01 | 2002-07-30 | Abbott Lab | Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes |
| US6329534B1 (en) | 1999-09-01 | 2001-12-11 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
| US8388986B2 (en) * | 2001-08-09 | 2013-03-05 | Laboratorios Miret S.A. | Use of cationic surfactants in cosmetic preparations |
| WO2003034842A1 (en) * | 2001-10-25 | 2003-05-01 | Laboratorios Miret, S.A. | Use of cationic preservative in food products |
| AU2002358540A1 (en) * | 2001-11-30 | 2003-06-10 | Solvay Pharmaceuticals Gmbh | Treatment of th2 dominated immunological disease states with progesterone receptor antagonists |
| CN101119970A (zh) * | 2004-01-09 | 2008-02-06 | 科赛普特治疗学股份有限公司 | 氮杂萘烷糖皮质激素受体调节剂 |
| JP4797326B2 (ja) * | 2004-01-27 | 2011-10-19 | 大正製薬株式会社 | 生薬含有組成物 |
-
2007
- 2007-07-19 TW TW096126375A patent/TW200820977A/zh unknown
- 2007-08-06 MX MX2009000950A patent/MX2009000950A/es not_active Application Discontinuation
- 2007-08-06 US US12/375,744 patent/US20100075936A1/en not_active Abandoned
- 2007-08-06 JP JP2009523270A patent/JP2010500323A/ja active Pending
- 2007-08-06 CN CNA2007800292934A patent/CN101500547A/zh active Pending
- 2007-08-06 KR KR1020097002988A patent/KR20090039775A/ko not_active Application Discontinuation
- 2007-08-06 EP EP10159050A patent/EP2204171A1/en not_active Withdrawn
- 2007-08-06 EP EP07788248A patent/EP2051705A2/en not_active Withdrawn
- 2007-08-06 WO PCT/EP2007/058134 patent/WO2008017658A2/en active Application Filing
- 2007-08-06 CA CA002658016A patent/CA2658016A1/en not_active Abandoned
- 2007-08-06 AU AU2007283604A patent/AU2007283604A1/en not_active Abandoned
- 2007-08-07 AR ARP070103470A patent/AR062229A1/es unknown
-
2009
- 2009-01-08 IL IL196392A patent/IL196392A0/en unknown
- 2009-01-12 ZA ZA2009/00242A patent/ZA200900242B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2204171A1 (en) | 2010-07-07 |
| CA2658016A1 (en) | 2008-02-14 |
| JP2010500323A (ja) | 2010-01-07 |
| ZA200900242B (en) | 2011-06-29 |
| CN101500547A (zh) | 2009-08-05 |
| US20100075936A1 (en) | 2010-03-25 |
| IL196392A0 (en) | 2009-09-22 |
| WO2008017658A2 (en) | 2008-02-14 |
| EP2051705A2 (en) | 2009-04-29 |
| AR062229A1 (es) | 2008-10-22 |
| AU2007283604A1 (en) | 2008-02-14 |
| KR20090039775A (ko) | 2009-04-22 |
| TW200820977A (en) | 2008-05-16 |
| WO2008017658A3 (en) | 2008-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: POP TEST CORTISOL LLC |
|
| FA | Abandonment or withdrawal |