MX2008011525A - Inhibidores de mnk2 de 8-heteroarilpurina para el tratamiento de trastornos metabolicos. - Google Patents
Inhibidores de mnk2 de 8-heteroarilpurina para el tratamiento de trastornos metabolicos.Info
- Publication number
- MX2008011525A MX2008011525A MX2008011525A MX2008011525A MX2008011525A MX 2008011525 A MX2008011525 A MX 2008011525A MX 2008011525 A MX2008011525 A MX 2008011525A MX 2008011525 A MX2008011525 A MX 2008011525A MX 2008011525 A MX2008011525 A MX 2008011525A
- Authority
- MX
- Mexico
- Prior art keywords
- purin
- amine
- ethyl
- pyridin
- phenyl
- Prior art date
Links
- 208000030159 metabolic disease Diseases 0.000 title claims abstract description 18
- 239000003112 inhibitor Substances 0.000 title abstract description 7
- 101710138999 MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 claims abstract description 27
- 102100033610 MAP kinase-interacting serine/threonine-protein kinase 2 Human genes 0.000 claims abstract description 26
- 238000011282 treatment Methods 0.000 claims abstract description 26
- 230000002265 prevention Effects 0.000 claims abstract description 23
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- 235000020824 obesity Nutrition 0.000 claims abstract description 20
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 18
- -1 cyano, nitro, amino Chemical group 0.000 claims description 375
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 155
- 150000001875 compounds Chemical class 0.000 claims description 106
- 125000000217 alkyl group Chemical group 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 42
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 32
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- 101710139011 MAP kinase-interacting serine/threonine-protein kinase 1 Proteins 0.000 claims description 26
- 102100026299 MAP kinase-interacting serine/threonine-protein kinase 1 Human genes 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 19
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 18
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
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- 125000004103 aminoalkyl group Chemical group 0.000 claims description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78080006P | 2006-03-09 | 2006-03-09 | |
| PCT/US2007/063699 WO2007104053A2 (en) | 2006-03-09 | 2007-03-09 | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008011525A true MX2008011525A (es) | 2008-09-18 |
Family
ID=38371082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011525A MX2008011525A (es) | 2006-03-09 | 2007-03-09 | Inhibidores de mnk2 de 8-heteroarilpurina para el tratamiento de trastornos metabolicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7951803B2 (OSRAM) |
| EP (1) | EP1991547A2 (OSRAM) |
| JP (1) | JP2009529541A (OSRAM) |
| KR (1) | KR20080107466A (OSRAM) |
| CN (1) | CN101454325A (OSRAM) |
| AU (1) | AU2007222982A1 (OSRAM) |
| BR (1) | BRPI0709007A2 (OSRAM) |
| CA (1) | CA2646429A1 (OSRAM) |
| EA (1) | EA014907B1 (OSRAM) |
| MX (1) | MX2008011525A (OSRAM) |
| WO (1) | WO2007104053A2 (OSRAM) |
| ZA (1) | ZA200807715B (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007030438A2 (en) * | 2005-09-06 | 2007-03-15 | Pharmacopeia, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
| JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
| WO2008051826A2 (en) * | 2006-10-20 | 2008-05-02 | N.V. Organon | Purines as pkc-theta inhibitors |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8685980B2 (en) | 2008-08-22 | 2014-04-01 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
| CA2790176A1 (en) * | 2010-02-18 | 2011-08-25 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Triazolo [4, 5 - b] pyridin derivatives |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| TW201141872A (en) * | 2010-02-26 | 2011-12-01 | Boehringer Ingelheim Int | Cycloalkyl containing thienopyrimidines for pharmaceutical compositions |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
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| JP2008534689A (ja) * | 2005-04-05 | 2008-08-28 | ファーマコペイア， インコーポレイテッド | 免疫抑制のためのプリン及びイミダゾピリジン誘導体 |
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| US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| WO2008051826A2 (en) * | 2006-10-20 | 2008-05-02 | N.V. Organon | Purines as pkc-theta inhibitors |
| US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
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2007
- 2007-03-09 JP JP2008558554A patent/JP2009529541A/ja active Pending
- 2007-03-09 AU AU2007222982A patent/AU2007222982A1/en not_active Abandoned
- 2007-03-09 CA CA002646429A patent/CA2646429A1/en not_active Abandoned
- 2007-03-09 CN CNA2007800157773A patent/CN101454325A/zh active Pending
- 2007-03-09 EP EP07758270A patent/EP1991547A2/en not_active Withdrawn
- 2007-03-09 US US11/684,262 patent/US7951803B2/en not_active Expired - Fee Related
- 2007-03-09 ZA ZA200807715A patent/ZA200807715B/xx unknown
- 2007-03-09 WO PCT/US2007/063699 patent/WO2007104053A2/en not_active Ceased
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- 2007-03-09 KR KR1020087024592A patent/KR20080107466A/ko not_active Withdrawn
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- 2007-03-09 MX MX2008011525A patent/MX2008011525A/es unknown
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2011
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|---|---|
| US20110230480A1 (en) | 2011-09-22 |
| CN101454325A (zh) | 2009-06-10 |
| EA014907B1 (ru) | 2011-02-28 |
| EA200801897A1 (ru) | 2009-02-27 |
| AU2007222982A1 (en) | 2007-09-13 |
| US7951803B2 (en) | 2011-05-31 |
| JP2009529541A (ja) | 2009-08-20 |
| EP1991547A2 (en) | 2008-11-19 |
| WO2007104053A3 (en) | 2007-11-01 |
| US20080032971A1 (en) | 2008-02-07 |
| KR20080107466A (ko) | 2008-12-10 |
| WO2007104053A2 (en) | 2007-09-13 |
| BRPI0709007A2 (pt) | 2011-06-21 |
| ZA200807715B (en) | 2009-11-25 |
| CA2646429A1 (en) | 2007-09-13 |
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